Reactome | INTS2 [nucleoplasm]

INTS2 [nucleoplasm]

Stable Identifier

R-SSC-6807448

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

INTS2, F1S221

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA polymerase II transcribes snRNA genes (Sus scrofa)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
    - Integrator complex processes the 3' end of snRNA (Sus scrofa)
      - Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Sus scrofa)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Sus scrofa)
      - Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Sus scrofa)
        
        Integrator [nucleoplasm] (Sus scrofa)
        
        INTS2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1S221

Gene Names

INTS2

Reference Genes

ENSEMBL:ENSSSCG00000017673.5

Other Identifiers

100525182

GO:0005634

GO:0016073

GO:0016180

GO:0032039

GO:0043226

Ssc.27467.1.S1_at

Ssc.29938.1.A1_at

Participates

as a component of

Integrator [nucleoplasm] (Sus scrofa)

Inferred From

INTS2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000108506

Ensembl

ENSSSCG00000017673, ENSSSCT00000019237, ENSSSCP00000018727

VGNC

89162