Reactome | POLE2 [nucleoplasm]

POLE2 [nucleoplasm]

Stable Identifier

R-SSC-68482

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

POLE2, F1SHZ5

Locations in the PathwayBrowser

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DNA Repair (Sus scrofa)

- Base Excision Repair (Sus scrofa)
  - Resolution of Abasic Sites (AP sites) (Sus scrofa)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Sus scrofa)
      - PCNA-Dependent Long Patch Base Excision Repair (Sus scrofa)
        
        LIG1 binds APEX1 and PCNA at SSB (Sus scrofa)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Sus scrofa)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Sus scrofa)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Sus scrofa)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
- DNA Damage Bypass (Sus scrofa)
  - Recognition of DNA damage by PCNA-containing replication complex (Sus scrofa)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Sus scrofa)
      - POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Sus scrofa)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Sus scrofa)
    - Termination of translesion DNA synthesis (Sus scrofa)
      - POLD,POLE binds deISGylated PCNA after TLS (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
- DNA Double-Strand Break Repair (Sus scrofa)
  - Homology Directed Repair (Sus scrofa)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
      - HDR through Homologous Recombination (HRR) (Sus scrofa)
        
        D-loop extension by DNA polymerases (Sus scrofa)
        
        PCNA:POLD,POLE,POLH,POLK:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
- Nucleotide Excision Repair (Sus scrofa)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Sus scrofa)
    - Dual Incision in GG-NER (Sus scrofa)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Sus scrofa)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE,POLK [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Sus scrofa)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Sus scrofa)
    - Dual incision in TC-NER (Sus scrofa)
      - 3' incision by ERCC5 (XPG) in TC-NER (Sus scrofa)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Sus scrofa)
        
        POLD,POLE,POLK [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Sus scrofa)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Sus scrofa)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Sus scrofa)
        
        PCNA:POLD,POLE [nucleoplasm] (Sus scrofa)
        
        POLD,POLE [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon [nucleoplasm] (Sus scrofa)
        
        POLE2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1SHZ5

Gene Names

POLE2

Reference Genes

BioGPS Gene:100521651 POLE2

ENSEMBL:ENSSSCG00000005008.5

ENSEMBL:ENSSSCG00005022149.1 POLE2

KEGG Gene (Sus scrofa):100521651 POLE2

Monarch:100521651 POLE2

NCBI Gene:100521651 POLE2

Reference Transcript

RefSeq:XM_003480468.3 POLE2

Other Identifiers

100521651

GO:0000228

GO:0003677

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006261

GO:0008622

GO:0016604

GO:0031981

GO:0043226

GO:0043231

Ssc.5371.1.S1_a_at

Ssc.5371.3.S1_a_at

Participates

as a component of

DNA polymerase epsilon [nucleoplasm] (Sus scrofa)

Inferred From

POLE2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_003480516.1

OpenTargets

ENSG00000100479

Ensembl

ENSSSCT00000005524, ENSSSCP00000005387, ENSSSCG00000005008

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