Reactome | MCM2 [nucleoplasm]

MCM2 [nucleoplasm]

Stable Identifier

R-SSC-68557

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

MCM2, A0A5G2Q7I1

Locations in the PathwayBrowser

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Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G2/M Checkpoints (Sus scrofa)
    - Activation of ATR in response to replication stress (Sus scrofa)
      - Activation of claspin (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - Loading of claspin onto DNA during replication origin firing (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Activation of the pre-replicative complex (Sus scrofa)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase alpha:primase binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        DNA polymerase epsilon binds at the origin (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
        
        MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        Mcm2-7 is phosphorylated by DDK (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        p-MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - Switching of origins to a post-replicative state (Sus scrofa)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        Orc1 removal from chromatin (Sus scrofa)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- DNA Replication Pre-Initiation (Sus scrofa)
  - Activation of the pre-replicative complex (Sus scrofa)
    - CDK and DDK associate with the Mcm10:pre-replicative complex (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - Cdc45 associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - Cdt1 is displaced from the pre-replicative complex. (Sus scrofa)
      - MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - DNA polymerase alpha:primase binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - DNA polymerase epsilon binds at the origin (Sus scrofa)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Sus scrofa)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        active pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Sus scrofa)
      - MCM10:pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - Mcm2-7 is phosphorylated by DDK (Sus scrofa)
      - MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - p-MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
  - Assembly of the pre-replicative complex (Sus scrofa)
    - Formation of MCM2-7 complex (Sus scrofa)
      - MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)
      - MCM2 [nucleoplasm] (Sus scrofa)
      - MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
- Synthesis of DNA (Sus scrofa)
  - Switching of origins to a post-replicative state (Sus scrofa)
    - Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)
      - MCM2 [nucleoplasm] (Sus scrofa)
      - MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
    - Orc1 removal from chromatin (Sus scrofa)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)
        
        pre-replicative complex [nucleoplasm] (Sus scrofa)
        
        MCM2-7 [nucleoplasm] (Sus scrofa)
        
        MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)
        
        MCM2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2Q7I1

Gene Names

MCM2

Reference Genes

ENSEMBL:ENSSSCG00000011624.5

Other Identifiers

100519111

GO:0000166

GO:0000228

GO:0000785

GO:0003677

GO:0003688

GO:0003824

GO:0004386

GO:0005524

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005737

GO:0006260

GO:0006268

GO:0006270

GO:0006325

GO:0006334

GO:0006915

GO:0007049

GO:0012501

GO:0016787

GO:0016887

GO:0019899

GO:0031090

GO:0032508

GO:0042393

GO:0042555

GO:0043226

GO:0048856

GO:0065003

GO:0071162

GO:0071353

GO:0090102

GO:0140657

GO:1905775

Ssc.1408.2.S1_at

Ssc.21350.1.S1_at

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Sus scrofa)

as an input of

MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Sus scrofa)

as a component of

MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Sus scrofa)

Inferred From

MCM2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000073111

Ensembl

ENSSSCG00000011624, ENSSSCT00000084126, ENSSSCP00000060039

VGNC

90073

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