Reactome | CCNA1 [nucleoplasm]

Cell Cycle (Sus scrofa)

- Cell Cycle Checkpoints (Sus scrofa)
  - G1/S DNA Damage Checkpoints (Sus scrofa)
    - p53-Dependent G1/S DNA damage checkpoint (Sus scrofa)
      - p53-Dependent G1 DNA Damage Response (Sus scrofa)
        
        Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G0 and Early G1 (Sus scrofa)
      - p107 (RBL1) binds CyclinE/A:CDK2 (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        RBL1:E2F4:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - p130 (RBL2) binds Cyclin E/A:CDK2 (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2 (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        RBL2:E2F4/5:DP1/2:Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
    - G1/S Transition (Sus scrofa)
      - Cyclin E associated events during G1/S transition (Sus scrofa)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Sus scrofa)
        
        Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Ubiquitination of phospho-p27/p21 (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
  - Mitotic G2-G2/M phases (Sus scrofa)
    - G2 Phase (Sus scrofa)
      - Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Sus scrofa)
        
        CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2:p-E2F1/p-E2F3 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
    - G2/M Transition (Sus scrofa)
      - Cyclin A/B1/B2 associated events during G2/M transition (Sus scrofa)
        
        CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Sus scrofa)
        
        CCNA:p-T14,T161-CDK1 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T14-CDK1 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Sus scrofa)
        
        p-CDK1/2:CCNA/p-T161-CDK1:CCNB1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-CDK1/2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T161-CDK1 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes (Sus scrofa)
        
        CCNA:p-T14,Y15,T161-CDK1 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T161-CDK1 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Sus scrofa)
        
        CCNA:p-T14-CDK1 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
  - Regulation of mitotic cell cycle (Sus scrofa)
    - APC/C-mediated degradation of cell cycle proteins (Sus scrofa)
      - Regulation of APC/C activators between G1/S and early anaphase (Sus scrofa)
        
        Association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
  - S Phase (Sus scrofa)
    - Cyclin A:Cdk2-associated events at S phase entry (Sus scrofa)
      - CAK-mediated phosphorylation of Cyclin A:Cdk2 (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-Y15-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - Cyclin A:Cdk2 mediated phosphorylation of p27/p21 (Sus scrofa)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:Cdk2:phospho-p27/p21 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - Phosphorylation of Cyclin A:Cdk2 at Tyr 15 (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-Y15-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - SCF(Skp2)-mediated degradation of p27/p21 (Sus scrofa)
        
        Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Ubiquitination of phospho-p27/p21 (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Sus scrofa)
        
        Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - Translocation of Cyclin A:Cdk2 complexes to the nucleus (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
    - Synthesis of DNA (Sus scrofa)
      - Switching of origins to a post-replicative state (Sus scrofa)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
        
        Cdc6 protein is phosphorylated by CDK (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Orc1 removal from chromatin (Sus scrofa)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
- Chromosome Maintenance (Sus scrofa)
  - Telomere Maintenance (Sus scrofa)
    - Extension of Telomeres (Sus scrofa)
      - Telomere Extension By Telomerase (Sus scrofa)
        
        CDK2:CCNA phosphorylates TERF2 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Recruitment of Telomerase RNP to the Telomeric Chromosome End (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)

Cellular responses to stimuli (Sus scrofa)

- Cellular responses to stress (Sus scrofa)
  - Cellular Senescence (Sus scrofa)
    - DNA Damage/Telomere Stress Induced Senescence (Sus scrofa)
      - Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
    - Senescence-Associated Secretory Phenotype (SASP) (Sus scrofa)
      - CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 (Sus scrofa)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)

DNA Repair (Sus scrofa)

- DNA Double-Strand Break Repair (Sus scrofa)
  - Homology Directed Repair (Sus scrofa)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
      - Processing of DNA double-strand break ends (Sus scrofa)
        
        CDK2 phosphorylates RBBP8 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        MRN complex binds CDK2 and RBBP8 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)

DNA Replication (Sus scrofa)

- Synthesis of DNA (Sus scrofa)
  - Switching of origins to a post-replicative state (Sus scrofa)
    - CDK-mediated phosphorylation and removal of Cdc6 (Sus scrofa)
      - Cdc6 protein is phosphorylated by CDK (Sus scrofa)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
    - Orc1 removal from chromatin (Sus scrofa)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - Generic Transcription Pathway (Sus scrofa)
    - Transcriptional Regulation by TP53 (Sus scrofa)
      - Regulation of TP53 Activity (Sus scrofa)
        
        Regulation of TP53 Activity through Phosphorylation (Sus scrofa)
        
        CDK2 phosphorylates TP53 (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Regulation of TP53 Expression and Degradation (Sus scrofa)
        
        Regulation of TP53 Degradation (Sus scrofa)
        
        (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Sus scrofa)
        
        CCNA:p-CDK1/2 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        CCNA:p-T161-CDK1 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
      - TP53 Regulates Transcription of Cell Cycle Genes (Sus scrofa)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Sus scrofa)
        
        Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Sus scrofa)
        
        CCNA:CDK2 [nucleoplasm] (Sus scrofa)
        
        CCNA [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Deubiquitination (Sus scrofa)
    - Ub-specific processing proteases (Sus scrofa)
      - USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Sus scrofa)
        
        USP37:RUVLB1:PSMC5:CCNA1,CCNA2 [nucleoplasm] (Sus scrofa)
        
        CCNA1,CCNA2 [nucleoplasm] (Sus scrofa)
        
        CCNA1 [nucleoplasm] (Sus scrofa)