Reactome | RPLP0 [cytosol]

RPLP0 [cytosol]

Stable Identifier

R-SSC-72396

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

RPLP0, Q29214

Locations in the PathwayBrowser

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Metabolism of RNA (Sus scrofa)

- Nonsense-Mediated Decay (NMD) (Sus scrofa)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Sus scrofa)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
    - SMG6 hydrolyzes mRNA with premature termination codon (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Sus scrofa)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Sus scrofa)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Sus scrofa)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Sus scrofa)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Sus scrofa)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Sus scrofa)
        
        80S ribosome [cytosol] (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)
- rRNA processing (Sus scrofa)
  - rRNA processing in the nucleus and cytosol (Sus scrofa)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Sus scrofa)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Sus scrofa)
        
        60S ribosomal complex [cytosol] (Sus scrofa)
        
        RPLP0 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:Q29214

Gene Names

RPLP0

Reference Genes

BioGPS Gene:100049695 RPLP0

ENSEMBL:ENSSSCG00000036014

ENSEMBL:ENSSSCG00000036014.3 RPLP0

ENSEMBL:ENSSSCG00025048049.1 RPLP0

ENSEMBL:ENSSSCG00030019041.1 RPLP0

ENSEMBL:ENSSSCG00035037418.1 RPLP0

ENSEMBL:ENSSSCG00045004115.1 RPLP0

ENSEMBL:ENSSSCG00050014204.1 RPLP0

ENSEMBL:ENSSSCG00055013468.1 RPLP0

ENSEMBL:ENSSSCG00060053490.1 RPLP0

ENSEMBL:ENSSSCG00065029708.1 RPLP0

ENSEMBL:ENSSSCG00070007168.1 RPLP0

KEGG Gene (Sus scrofa):100049695 RPLP0

Monarch:100049695 RPLP0

NCBI Gene:100049695 RPLP0

Reference Transcript

RefSeq:NM_001098598.1 RPLP0

Other Identifiers

100049695

GO:0005737

GO:0005829

GO:0005840

GO:0016020

GO:0022625

GO:0030425

GO:0042254

GO:0043226

GO:0045202

GO:0071353

Ssc.929.2.S1_at

Participates

as a component of

Inferred From

RPLP0 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001092068.1

OpenTargets

ENSG00000089157

Ensembl

ENSSSCG00000036014, ENSSSCT00000043457, ENSSSCP00000044506

PDB

6MTD, 6MTE, 3J7P

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