Reactome | S100A12 [extracellular region]

S100A12 [extracellular region]

Stable Identifier

R-SSC-879450

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

extracellular region

Synonyms

S100A12, A0A5S6H0X2

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-1 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Advanced glycosylation endproduct receptor signaling (Sus scrofa)
    - Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Sus scrofa)
      - AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
      - AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
  - DDX58/IFIH1-mediated induction of interferon-alpha/beta (Sus scrofa)
    - TRAF6 mediated NF-kB activation (Sus scrofa)
      - NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
  - Neutrophil degranulation (Sus scrofa)
    - Exocytosis of secretory granule lumen proteins (Sus scrofa)
      - Secretory granule lumen proteins [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        NF-kappa-B complex is transported from cytosol to nucleus (Sus scrofa)
        
        AGER ligands:AGER [plasma membrane] (Sus scrofa)
        
        AGER ligands [extracellular region] (Sus scrofa)
        
        S100A12 dimer [extracellular region] (Sus scrofa)
        
        Homologues of S100A12 [extracellular region] (Sus scrofa)
        
        S100A12 [extracellular region] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5S6H0X2

Gene Names

S100A12

Reference Genes

ENSEMBL:ENSSSCG00000032857.3

Other Identifiers

100301483

GO:0002376

GO:0005509

GO:0005634

GO:0005737

GO:0006805

GO:0023052

GO:0031640

GO:0042802

GO:0043123

GO:0043226

GO:0043542

GO:0048306

GO:0048870

GO:0050786

GO:0050832

GO:0061844

GO:0098542

Participates

as a member of

Homologues of S100A12 [extracellular region] (Sus scrofa)

Other forms of this molecule

S100A12 [secretory granule lumen]

Inferred From

S100A12 [extracellular region] (Homo sapiens)

Cross References

OpenTargets

ENSG00000163221

Ensembl

ENSSSCP00000032082, ENSSSCT00000066217, ENSSSCG00000032857

VGNC

92538

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