Reactome | THOC2 [nucleoplasm]

THOC2 [nucleoplasm]

Stable Identifier

R-SSC-8849134

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

THOC2, A0A287AC85

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Sus scrofa)

- RNA Polymerase II Transcription (Sus scrofa)
  - RNA Polymerase II Transcription Termination (Sus scrofa)
    - Cleavage of mRNA at the 3'-end (Sus scrofa)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)

Metabolism of RNA (Sus scrofa)

- Processing of Capped Intron-Containing Pre-mRNA (Sus scrofa)
  - Transport of Mature Transcript to Cytoplasm (Sus scrofa)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Sus scrofa)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Sus scrofa)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Sus scrofa)
        
        TREX (minus DDX39B) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
  - mRNA 3'-end processing (Sus scrofa)
    - Cleavage of mRNA at the 3'-end (Sus scrofa)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Sus scrofa)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
      - THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
    - mRNA polyadenylation (Sus scrofa)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)
      - polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Sus scrofa)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Sus scrofa)
        
        THO complex [nucleoplasm] (Sus scrofa)
        
        THOC2 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287AC85

Gene Names

THOC2

Reference Genes

BioGPS Gene:100154832 THOC2

ENSEMBL:ENSSSCG00000012639.6

Monarch:100154832 THOC2

NCBI Gene:100154832 THOC2

Reference Transcript

RefSeq:XM_013986397.1 THOC2

Other Identifiers

100154832

GO:0000346

GO:0000347

GO:0000445

GO:0000781

GO:0005634

GO:0005694

GO:0006397

GO:0006406

GO:0006913

GO:0016071

GO:0016973

GO:0030154

GO:0043226

GO:0046784

GO:0048666

GO:0048699

GO:0048856

Ssc.21213.1.S1_at

Ssc.25837.1.S1_a_at

Ssc.29008.1.S1_at

Participates

as a component of

THO complex [nucleoplasm] (Sus scrofa)

Inferred From

THOC2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_013841851.1

OpenTargets

ENSG00000125676

Ensembl

ENSSSCG00000012639, ENSSSCT00000040325, ENSSSCP00000041432

VGNC

93957