Reactome | FCHO1 [cytosol]

FCHO1 [cytosol]

Stable Identifier

R-SSC-8862257

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

FCHO1, A0A5G2QWE5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Sus scrofa)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
    - Cargo recognition for clathrin-mediated endocytosis (Sus scrofa)
      - ARBB recruits GPCRs into clathrin-coated pits (Sus scrofa)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
    - Clathrin recruits PIK3C2A (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Sus scrofa)
      - FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
    - Recruitment of AP-2 complex and clathrin (Sus scrofa)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Sus scrofa)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Sus scrofa)
        
        FCHO1,2 dimer [cytosol] (Sus scrofa)
        
        FCHO1 dimer [cytosol] (Sus scrofa)
        
        FCHO1 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QWE5

Gene Names

FCHO1

Reference Genes

ENSEMBL:ENSSSCG00000013885.5

Other Identifiers

100518178

GO:0002376

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0005905

GO:0007155

GO:0016192

GO:0023052

GO:0035612

GO:0043226

GO:0048268

GO:0050852

GO:0050870

GO:0065003

GO:0072583

Ssc.20004.1.S1_at

Participates

as a component of

FCHO1 dimer [cytosol] (Sus scrofa)

Inferred From

FCHO1 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000130475

Ensembl

ENSSSCP00000068475, ENSSSCG00000013885, ENSSSCT00000071888

VGNC

88065

Cite Us!