Reactome | CD4 [clathrin-coated endocytic vesicle membrane]

CD4 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-SSC-8869082

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

CD4, I3L556

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Sus scrofa)

- Membrane Trafficking (Sus scrofa)
  - Clathrin-mediated endocytosis (Sus scrofa)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Sus scrofa)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane] (Sus scrofa)
        
        CD4 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

External Reference Information

External Reference

UniProt:I3L556

Gene Names

CD4

Reference Genes

ENSEMBL:ENSSSCG00000000687

Other Identifiers

404704

GO:0001934

GO:0002250

GO:0002376

GO:0003674

GO:0005575

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0006948

GO:0006955

GO:0007155

GO:0007165

GO:0008150

GO:0008270

GO:0009058

GO:0009897

GO:0015026

GO:0016020

GO:0016021

GO:0019899

GO:0019901

GO:0030154

GO:0030217

GO:0030225

GO:0032507

GO:0033674

GO:0034641

GO:0035723

GO:0042011

GO:0042012

GO:0042110

GO:0042289

GO:0042802

GO:0042803

GO:0043123

GO:0043167

GO:0043410

GO:0044403

GO:0045058

GO:0045121

GO:0045657

GO:0045860

GO:0045893

GO:0046598

GO:0048856

GO:0050863

GO:0051924

GO:0070374

GO:0097011

GO:1990782

Ssc.16239.1.S1_s_at

Participant Of

hasMember

AP-2 dileucine-containing cargo [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

CD4 [plasma membrane]

Inferred From

CD4 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000010610

Ensembl

ENSSSCT00000030772, ENSSSCP00000019155, ENSSSCG00000000687

VGNC

86417

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