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TOP3A [nucleoplasm]
Stable Identifier
R-SSC-912452
Type
Protein [EntityWithAccessionedSequence]
Species
Sus scrofa
Compartment
nucleoplasm
Synonyms
TOP3A, A0A287BF93
Locations in the PathwayBrowser
Expand all
Cell Cycle (Sus scrofa)
Cell Cycle Checkpoints (Sus scrofa)
G2/M Checkpoints (Sus scrofa)
G2/M DNA damage checkpoint (Sus scrofa)
ATR phosphorylates TP53 (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
DNA Repair (Sus scrofa)
DNA Double-Strand Break Repair (Sus scrofa)
Homology Directed Repair (Sus scrofa)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Sus scrofa)
HDR through Homologous Recombination (HRR) (Sus scrofa)
D-loop extension by DNA polymerases (Sus scrofa)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Homologous DNA Pairing and Strand Exchange (Sus scrofa)
CX3 complex binds D-loop structures (Sus scrofa)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Presynaptic phase of homologous DNA pairing and strand exchange (Sus scrofa)
BCDX2 complex stabilizes RAD51 filament (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Resolution of D-Loop Structures (Sus scrofa)
Resolution of D-loop Structures through Holliday Junction Intermediates (Sus scrofa)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Sus scrofa)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Ligation of DNA and formation of Holliday structures following repair synthesis (Sus scrofa)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
MUS81:EME1,EME2 cleaves D-loop (Sus scrofa)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Sus scrofa)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
SPIDR binds BLM:TOP3A:RMI1:RMI2 (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
HDR through Single Strand Annealing (SSA) (Sus scrofa)
Association of RAD51 with RAD52:DNA double-strand break ends (Sus scrofa)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Association of RAD52 with the RPA complex at resected DNA DSBs (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
ERCC1:XPF cleaves flaps generated by SSA (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
RAD52 promotes single strand annealing at resected DNA DSBs (Sus scrofa)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Processing of DNA double-strand break ends (Sus scrofa)
ATR activation at DNA DSBs (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
ATR phosphorylates RPA2 (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Activation of CHEK1 at resected DNA DSBs (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Association of RPA complexes with ssDNA at resected DNA DSBs (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Binding of ATR:ATRIP to RPA at resected DNA DSBs (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
CHEK1 is recruited to resected DNA DSBs (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Sus scrofa)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
Gene expression (Transcription) (Sus scrofa)
RNA Polymerase II Transcription (Sus scrofa)
Generic Transcription Pathway (Sus scrofa)
Transcriptional Regulation by TP53 (Sus scrofa)
Regulation of TP53 Activity (Sus scrofa)
Regulation of TP53 Activity through Phosphorylation (Sus scrofa)
ATR phosphorylates TP53 (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Sus scrofa)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Sus scrofa)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Sus scrofa)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
TOP3A [nucleoplasm] (Sus scrofa)
External Reference Information
External Reference
UniProt:A0A287BF93
Gene Names
TOP3A
Reference Genes
ENSEMBL:ENSSSCG00000035839.3
Other Identifiers
110256129
GO:0000724
GO:0003677
GO:0003697
GO:0003824
GO:0003916
GO:0003917
GO:0005634
GO:0005654
GO:0005694
GO:0005739
GO:0006265
GO:0006281
GO:0006310
GO:0007005
GO:0007059
GO:0008270
GO:0016605
GO:0016853
GO:0031422
GO:0032042
GO:0043226
GO:0046872
GO:0051304
GO:0071139
GO:0140097
Ssc.26603.1.S1_at
Participates
as a component of
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Sus scrofa)
Inferred From
TOP3A [nucleoplasm]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000177302
Ensembl
ENSSSCG00000035839
,
ENSSSCP00000055234
,
ENSSSCT00000041622
VGNC
94312
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