Reactome | phospho-TIFA [cytosol]

phospho-TIFA [cytosol]

Stable Identifier

R-SSC-9645512

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

p-T9-TIFA, F1S141

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Cytokine Signaling in Immune system (Sus scrofa)
  - Signaling by Interleukins (Sus scrofa)
    - Interleukin-1 family signaling (Sus scrofa)
      - Interleukin-1 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - Alpha-protein kinase 1 signaling pathway (Sus scrofa)
    - ALPK1 phosphorylates TIFA (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - TIFA oligomerization (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 10 (TLR10) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Toll Like Receptor 2 (TLR2) Cascade (Sus scrofa)
      - Toll Like Receptor TLR1:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - Toll Like Receptor TLR6:TLR2 Cascade (Sus scrofa)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Toll Like Receptor 3 (TLR3) Cascade (Sus scrofa)
      - TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - MyD88-independent TLR4 cascade (Sus scrofa)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Toll Like Receptor 5 (TLR5) Cascade (Sus scrofa)
      - MyD88 cascade initiated on plasma membrane (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)
    - Toll Like Receptor 9 (TLR9) Cascade (Sus scrofa)
      - MyD88 dependent cascade initiated on endosome (Sus scrofa)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
        
        TAK1-dependent IKK and NF-kappa-B activation (Sus scrofa)
        
        Ubiquitination of IKBKG by TRAF6 (Sus scrofa)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Sus scrofa)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Sus scrofa)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)
        
        phospho-TIFA [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1S141

Gene Names

TIFA

Reference Genes

BioGPS Gene:100513485 TIFA

ENSEMBL:ENSSSCG00000009129.5

KEGG Gene (Sus scrofa):100513485 TIFA

Monarch:100513485 TIFA

NCBI Gene:100513485 TIFA

Reference Transcript

Other Identifiers

100513485

GO:0002376

GO:0002753

GO:0005515

GO:0005737

GO:0007249

GO:0023052

GO:0043123

GO:0045087

GO:0050896

GO:0051260

GO:0065003

GO:0098542

Ssc.3719.1.S1_at

Participates

as a component of

p-T9-TIFA:p-T9-TIFA [cytosol] (Sus scrofa)

Other forms of this molecule

TIFA [cytosol]

Inferred From

p-T9-TIFA [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 9 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_013834402.1, XP_013834404.1, XP_013834401.1, XP_005666986.1

OpenTargets

ENSG00000145365

Ensembl

ENSSSCP00000035836, ENSSSCG00000009129, ENSSSCT00000057782

VGNC

93978

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