Reactome | ASB14 [cytosol]

ASB14 [cytosol]

Stable Identifier

R-SSC-975421

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

ASB14, A0A287BAX4

Locations in the PathwayBrowser

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Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Class I MHC mediated antigen processing & presentation (Sus scrofa)
    - Antigen processing: Ubiquitination & Proteasome degradation (Sus scrofa)
      - Interaction of E3 with substrate and E2-Ub complex (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
      - Polyubiquitination of substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
      - Release of E3 from polyubiquitinated substrate (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
      - Transfer of Ub from E2 to substrate and release of E2 (Sus scrofa)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
        
        E3:Ub:substrate [cytosol] (Sus scrofa)
        
        E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Sus scrofa)
        
        ASB family [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Sus scrofa)
        
        CUL5-box protein [cytosol] (Sus scrofa)
        
        ASB14 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287BAX4

Gene Names

ASB14

Reference Genes

ENSEMBL:ENSSSCG00000035320.1

ENSEMBL:ENSSSCG00005021599.1 ASB14

Other Identifiers

110256252

GO:0016567

GO:0023052

GO:0035556

GO:0036211

Participates

as a member of

Inferred From

ASB14 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000239388

Ensembl

ENSSSCT00000063151, ENSSSCG00000035320, ENSSSCP00000053251

VGNC

85562

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