Reactome | PLCG2 [cytosol]

PLCG2 [cytosol]

Stable Identifier

R-SSC-984806

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

PLCG2, F1S475

Locations in the PathwayBrowser

Expand all

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - Signaling by the B Cell Receptor (BCR) (Sus scrofa)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
      - BTK binds BTK inhibitors (Sus scrofa)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
        
        PLCG2:PIP3 [plasma membrane] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        BTK:BTK inhibitors [plasma membrane] (Sus scrofa)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
        
        PLCG2:PIP3 [plasma membrane] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Sus scrofa)
        
        Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Sus scrofa)
        
        PLCG2:PIP3 [plasma membrane] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - p-DAPP1 (p-BAM32) binds PLCG2 (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
- Innate Immune System (Sus scrofa)
  - C-type lectin receptors (CLRs) (Sus scrofa)
    - Dectin-2 family (Sus scrofa)
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Sus scrofa)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
  - DAP12 interactions (Sus scrofa)
    - DAP12 signaling (Sus scrofa)
      - Activation of RAC1 by VAV2/3 (Sus scrofa)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylation of BTK by p-SYK (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-SYK/p-BTK [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Recruitment of VAV and BTK to p-SLP-76 (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
  - Fc epsilon receptor (FCERI) signaling (Sus scrofa)
    - FCERI mediated Ca+2 mobilization (Sus scrofa)
      - Autophosphorylation of BTK/ITK (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylation of TEC kinases by p-SYK (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
    - FCERI mediated MAPK activation (Sus scrofa)
      - Activation of RAC1 by VAV (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Autophosphorylation of PAK (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylation and activation of VAV (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Phosphorylation of SLP-76 by p-SYK (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Recruitment of PAK to the membrane by binding active RAC1 (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Recruitment of VAV to p-SLP-76 (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Sus scrofa)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Sus scrofa)
    - Role of phospholipids in phagocytosis (Sus scrofa)
      - Phosphorylation and activation of PLCG (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
      - Recruitment of PLCgamma to membrane (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Sus scrofa)
        
        PLC gamma1,2 [cytosol] (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)
  - Toll-like Receptor Cascades (Sus scrofa)
    - Toll Like Receptor 4 (TLR4) Cascade (Sus scrofa)
      - Endocytosis of TLR4:LY96:LPS:CD14 (Sus scrofa)
        
        PLCG2 [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:F1S475

Gene Names

PLCG2

Reference Genes

ENSEMBL:ENSSSCG00000002688.4

UCSC:F1S475 PLCG2

Other Identifiers

100518663

GO:0001775

GO:0001784

GO:0001878

GO:0002092

GO:0002223

GO:0002224

GO:0002281

GO:0002316

GO:0002376

GO:0002732

GO:0003824

GO:0004435

GO:0005737

GO:0005829

GO:0005886

GO:0006629

GO:0006661

GO:0006954

GO:0007165

GO:0008081

GO:0009395

GO:0010468

GO:0010628

GO:0012501

GO:0016042

GO:0016192

GO:0016787

GO:0019216

GO:0019722

GO:0019901

GO:0023052

GO:0030154

GO:0030183

GO:0031663

GO:0032481

GO:0032496

GO:0032587

GO:0032733

GO:0032735

GO:0032743

GO:0032747

GO:0032755

GO:0032760

GO:0032959

GO:0035556

GO:0036211

GO:0043069

GO:0043122

GO:0043226

GO:0043410

GO:0045121

GO:0048471

GO:0048678

GO:0048856

GO:0050731

GO:0050850

GO:0050852

GO:0050853

GO:0050896

GO:0051209

GO:0055065

GO:0055085

GO:0060100

GO:0060907

GO:0061024

GO:0061760

GO:0065003

GO:0070884

GO:0071277

GO:0071396

GO:0097110

GO:0097708

GO:0098542

GO:0140031

GO:0150078

GO:1900227

GO:1903428

GO:1903721

GO:1990782

GO:1990858

Ssc.24329.1.A1_at

Participates

as an input of

as a component of

as a member of

PLC gamma1,2 [cytosol] (Sus scrofa)

This entity regulates

Positively

Endocytosis of TLR4:LY96:LPS:CD14 (Sus scrofa)

Other forms of this molecule

phospho-PLCG2 [cytosol]

phospho-PLCG2 [plasma membrane]

PLCG2 [plasma membrane]

phospho-PLCG2 [plasma membrane]

Inferred From

PLCG2 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSSSCG00000002688, ENSSSCT00000002981, ENSSSCP00000002902

VGNC

91520

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