Reactome: A Curated Pathway Database

DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)

Stable Identifier
R-TGU-5649799
Type
Reaction
Species
Taeniopygia guttata
Compartment
Synonyms
DOT1L (KMT4) methylates Me2K80-histone H3 (H3K79), DOT1L methylates dimethyl-lysine-80 of histone H3
Locations in the PathwayBrowser
Summation

This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
histone-lysine N-methyltransferase activity of DOT1L [nucleoplasm] DOT1L [nucleoplasm] histone-lysine N-methyltransferase activity (0018024)
Inferred From