p-S67-Ensa/p-S67-Arpp19 binds PP2A-Ppp2r2d

Stable Identifier
R-XLA-2445086
Type
Reaction [binding]
Species
Xenopus laevis
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-S67-Ensa/p-S67-Arpp19 binds PP2A-Ppp2r2d
Recombinant Xenopus Ensa and Arpp19 are phosphorylated by recombinant Xenopus Mastl on serine residue S67. Once phosphorylated, Ensa and Arpp19 bind and inhibit the phosphatase activity of PP2A complexed with the regulatory subunit Ppp2r2d (B55-delta) (Mochida et al. 2010, Gharbi-Ayachi et al. 2010).
Literature References
PubMed ID Title Journal Year
21164013 Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis

Skehel, M, Mochida, S, Hunt, T, Maslen, SL

Science 2010
21164014 The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A

Lorca, T, Burgess, A, Van-Dorsselaer, A, Vigneron, S, Strub, JM, Gharbi-Ayachi, A, Castro, A, Brioudes, E, Labbe, JC

Science 2010
Participants
Input
Output
Orthologous Events
p-S62-ARPP19/p-S67-ENSA binds PP2A-PPP2R2D (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-09-04)
Reviewed
Mochida, S  (2012-09-26)
Burgess, A  (2012-09-28)
Created
Orlic-Milacic, M  (2012-08-11)
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