Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-map2k1 [cytosol]
Stable Identifier
R-XTR-109837
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
p-S218,S222-MAP2K1, Q66JE6
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF-independent MAPK1/3 activation (Xenopus tropicalis)
MAPK3 (ERK1) activation (Xenopus tropicalis)
Inactivation of MAP2K1 by CDK1 (Xenopus tropicalis)
MAP2K1 [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
MAP2K and MAPK activation (Xenopus tropicalis)
Dissociation of RAS:RAF complex (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
Dual mechanism MAPK inhibitors bind MAPKs (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
IL17RD binds p-2S MAP2Ks and MAPKs (Xenopus tropicalis)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Xenopus tropicalis)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Xenopus tropicalis)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
RAF phosphorylates MAP2K dimer (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
RAF activation (Xenopus tropicalis)
Phosphorylation of RAF (Xenopus tropicalis)
RAF activating kinases [plasma membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
Signalling to ERKs (Xenopus tropicalis)
Prolonged ERK activation events (Xenopus tropicalis)
Frs2-mediated activation (Xenopus tropicalis)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Xenopus tropicalis)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
Dissociation of phosphorylated MAP2Ks and MAPKs (Xenopus tropicalis)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Xenopus tropicalis)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Xenopus tropicalis)
p-S218,S222 MAP2K1 dimer [cytosol] (Xenopus tropicalis)
phospho-map2k1 [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:Q66JE6
Gene Names
map2k1
Reference Genes
BioGPS Gene:493420 map2k1
ENSEMBL:ENSXETG00000015887
KEGG Gene (Xenopus tropicalis):493420 map2k1
Monarch:493420 map2k1
NCBI Gene:493420 map2k1
Reference Transcript
RefSeq:NM_001008057.1 map2k1
Other Identifiers
493420
GO:0000165
GO:0000166
GO:0000187
GO:0003674
GO:0004672
GO:0004674
GO:0004708
GO:0004984
GO:0005524
GO:0005575
GO:0006464
GO:0006468
GO:0007165
GO:0007186
GO:0008150
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0043167
GO:0050877
GO:0050911
Str.10686.1.S1_a_at
Participant Of
hasMember
MAP2K1 [cytosol]
hasComponent
p-S218,S222 MAP2K1 dimer [cytosol]
Other forms of this molecule
map2k1 [cytosol]
phospho-map2k1 [cytosol]
phospho-map2k1 [cytosol]
Inferred From
p-S218,S222-MAP2K1 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001008058.1
Ensembl
ENSXETT00000034662
,
ENSXETP00000034662
,
ENSXETG00000015887
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text