Reactome | hbegf [extracellular region]

hbegf [extracellular region]

Stable Identifier

R-XTR-1233234

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

extracellular region

Synonyms

HBEGF(63-148), A0A6I8QCY1

Locations in the PathwayBrowser

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Signal Transduction (Xenopus tropicalis)

- Intracellular signaling by second messengers (Xenopus tropicalis)
  - PIP3 activates AKT signaling (Xenopus tropicalis)
    - Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Xenopus tropicalis)
        
        PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
        
        Activator:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - PI3K phosphorylates PIP2 to PIP3 (Xenopus tropicalis)
      - Activator:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
- MAPK family signaling cascades (Xenopus tropicalis)
  - MAPK1/MAPK3 signaling (Xenopus tropicalis)
    - RAF/MAP kinase cascade (Xenopus tropicalis)
      - RAS GEFs promote RAS nucleotide exchange (Xenopus tropicalis)
        
        RAS GEFs [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
- Signaling by GPCR (Xenopus tropicalis)
  - GPCR downstream signalling (Xenopus tropicalis)
    - G alpha (q) signalling events (Xenopus tropicalis)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Xenopus tropicalis)
        
        EGFR Transactivation by Gastrin (Xenopus tropicalis)
        
        GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Xenopus tropicalis)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Xenopus tropicalis)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
- Signaling by Non-Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by PTK6 (Xenopus tropicalis)
    - PTK6 promotes HIF1A stabilization (Xenopus tropicalis)
      - EGFR phosphorylates GPNMB (Xenopus tropicalis)
        
        HBEGF:EGFR:GPNMB [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - HBEGF-bound EGFR forms a heterodimer with GPNMB (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        HBEGF:EGFR:GPNMB [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - LINC01139 facilitates PTK6 autophosphorylation (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - LINC01139 promotes phosphorylation of HIF1A by PTK6 (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Xenopus tropicalis)
        
        HBEGF:EGFR [plasma membrane] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
- Signaling by Nuclear Receptors (Xenopus tropicalis)
  - ESR-mediated signaling (Xenopus tropicalis)
    - Extra-nuclear estrogen signaling (Xenopus tropicalis)
      - MMPs cleave HB-EGF (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by EGFR (Xenopus tropicalis)
    - EGFR autophosphorylation (Xenopus tropicalis)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGFR:EGF-like ligands [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - EGFR binds EGF ligand (Xenopus tropicalis)
      - EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - EGFR:EGF-like ligands [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - EGFR dimerization (Xenopus tropicalis)
      - EGF-like ligands:EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGFR:EGF-like ligands [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - EGFR:EGF-like ligands [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - EGFR downregulation (Xenopus tropicalis)
      - CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - CBL ubiquitinates Sprouty (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - Phosphorylation of CBL (EGFR:GRB2:CBL) (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - Ubiquitination of stimulated EGFR (CBL:GRB2) (Xenopus tropicalis)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - EGFR interacts with phospholipase C-gamma (Xenopus tropicalis)
      - Active PLC-gamma1 dissociates from EGFR (Xenopus tropicalis)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - EGFR activates PLC-gamma1 by phosphorylation (Xenopus tropicalis)
        
        EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - Phospholipase C-gamma1 binds to the activated EGF receptor (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - GAB1 signalosome (Xenopus tropicalis)
      - Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - GRB2:GAB1 binds to phosphorylated EGFR (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - PI3K binds to EGF:EGFR:GRB2:GAB1 (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - SHP2 dephosphorylates Tyr 992 on EGFR (Xenopus tropicalis)
        
        EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:Phospho-EGFR (-Y1016) dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:Phospho-EGFR (- Y992) [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - GRB2 events in EGFR signaling (Xenopus tropicalis)
      - GRB2:SOS1 complex binds to EGF:EGFR complex (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - SHC1 events in EGFR signaling (Xenopus tropicalis)
      - GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - SHC1 phosphorylation by phosphorylated EGFR (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
  - Signaling by ERBB4 (Xenopus tropicalis)
    - ERBB4 binds NRGs or EGF-like ligands (Xenopus tropicalis)
      - EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - ERBB4 forms heterodimers with EGFR (Xenopus tropicalis)
      - ERBB4:EGFR heterodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - Homodimerization of ERBB4 (Xenopus tropicalis)
      - ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - PI3K events in ERBB4 signaling (Xenopus tropicalis)
      - Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Xenopus tropicalis)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - SHC1 events in ERBB4 signaling (Xenopus tropicalis)
      - Phosphorylation of SHC1 by ERBB4 homodimers (Xenopus tropicalis)
        
        SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Xenopus tropicalis)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Xenopus tropicalis)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
    - Trans-autophosphorylation of ERBB4 homodimers (Xenopus tropicalis)
      - ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
      - p-ERBB4 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Xenopus tropicalis)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Xenopus tropicalis)
        
        EGF-like ligands [extracellular region] (Xenopus tropicalis)
        
        hbegf [extracellular region] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8QCY1

Gene Names

hbegf

Reference Genes

BioGPS Gene:100497436 hbegf

ENSEMBL:ENSXETG00000039798

KEGG Gene (Xenopus tropicalis):100497436 hbegf

Monarch:100497436 hbegf

NCBI Gene:100497436 hbegf

Reference Transcript

RefSeq:XM_002937727.5 hbegf

Other Identifiers

100497436

GO:0016020

Participates

as an output of

MMPs cleave HB-EGF (Xenopus tropicalis)

as a component of

as an input of

Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Xenopus tropicalis)

as a member of

Other forms of this molecule

hbegf [plasma membrane]

Inferred From

HBEGF(63-148) [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_002937773.1

Xenbase

XB-GENE-13579793

Ensembl

ENSXETT00000097762, ENSXETP00000067450, ENSXETG00000039798

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