Reactome | grap2 [cytosol]

grap2 [cytosol]

Stable Identifier

R-XTR-202367

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

GRAP2, A0A6I8QQ68

Locations in the PathwayBrowser

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Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Costimulation by the CD28 family (Xenopus tropicalis)
    - CD28 co-stimulation (Xenopus tropicalis)
      - Gads binds CD28 (Xenopus tropicalis)
        
        CD28:GRAP2 [plasma membrane] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
  - TCR signaling (Xenopus tropicalis)
    - Generation of second messenger molecules (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma1 (Xenopus tropicalis)
        
        ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Xenopus tropicalis)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-5Y-LAT [plasma membrane] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Xenopus tropicalis)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-5Y-LAT [plasma membrane] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Xenopus tropicalis)
        
        p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-5Y-LAT [plasma membrane] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
- Innate Immune System (Xenopus tropicalis)
  - DAP12 interactions (Xenopus tropicalis)
    - DAP12 signaling (Xenopus tropicalis)
      - Activation of RAC1 by VAV2/3 (Xenopus tropicalis)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV and BTK to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Release of p-PLCG1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
  - Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
    - FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
      - Autophosphorylation of BTK/ITK (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
    - FCERI mediated MAPK activation (Xenopus tropicalis)
      - Activation of RAC1 by VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Autophosphorylation of PAK (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Phosphorylation and activation of VAV (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Recruitment of PAK to the membrane by binding active RAC1 (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Xenopus tropicalis)
        
        GADS:SLP76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
      - Recruitment of VAV to p-SLP-76 (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Xenopus tropicalis)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Xenopus tropicalis)
        
        GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Xenopus tropicalis)
        
        grap2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8QQ68

Gene Names

grap2

Reference Genes

BioGPS Gene:100492322 grap2

ENSEMBL:ENSXETG00000016137

KEGG Gene (Xenopus tropicalis):100492322 grap2

Monarch:100492322 grap2

NCBI Gene:100492322 grap2

Reference Transcript

RefSeq:XM_002933747.2 grap2

Other Identifiers

100492322

GO:0005515

Participates

as an input of

Gads binds CD28 (Xenopus tropicalis)

as a component of

as a member of

Adapter proteins [cytosol] (Xenopus tropicalis)

Inferred From

GRAP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_002933793.1

Xenbase

XB-GENE-6086850

Ensembl

ENSXETP00000074461, ENSXETG00000016137, ENSXETT00000066912

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