Reactome | nck2 [cytosol]

nck2 [cytosol]

Stable Identifier

R-XTR-204885

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

NCK2, Q66K98

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - EPH-Ephrin signaling (Xenopus tropicalis)
      - Ephrin signaling (Xenopus tropicalis)
        
        GIT1 binds bPIX (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        PAK binds RAC and bPIX (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        PAKs autophosphorylate (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        PAKs phosphorylate MLC (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        p-EFNB binds GRB4 (Xenopus tropicalis)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by PDGF (Xenopus tropicalis)
    - Downstream signal transduction (Xenopus tropicalis)
      - Nck binds to the active PDGF receptor (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
  - Signaling by VEGF (Xenopus tropicalis)
    - VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
      - CDC42:GTP binds PAK2 (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - FYN autophosphorylates (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - FYN phosphorylates PAK2 (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - PAK2 autophorylates (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - p-6Y-VEGFR2 binds NCK (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - p-Y420-FYN is phosphorylated on S21 (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - p38 MAPK activation by VEGFR (Xenopus tropicalis)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Xenopus tropicalis)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Xenopus tropicalis)
        
        NCK1,NCK2 [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
  - Signaling by Rho GTPases (Xenopus tropicalis)
    - RHO GTPase cycle (Xenopus tropicalis)
      - RHOU GTPase cycle (Xenopus tropicalis)
        
        RHOU binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RHOU effectors [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Xenopus tropicalis)
        
        RHOU effectors [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
      - RHOV GTPase cycle (Xenopus tropicalis)
        
        RHOV binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RHOV effectors [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Xenopus tropicalis)
        
        RHOV effectors [cytosol] (Xenopus tropicalis)
        
        nck2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q66K98

Gene Names

nck2

Reference Genes

BioGPS Gene:493349 nck2

ENSEMBL:ENSXETG00000021669

KEGG Gene (Xenopus tropicalis):493349 nck2

Monarch:493349 nck2

NCBI Gene:493349 nck2

Reference Transcript

Other Identifiers

493349

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0006417

GO:0007010

GO:0030838

GO:0043226

GO:0065003

Participates

as a candidate of

RHOV effectors [cytosol] (Xenopus tropicalis)

as a member of

as an input of

p-EFNB binds GRB4 (Xenopus tropicalis)

as a component of

EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Xenopus tropicalis)

Inferred From

NCK2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017946679.1, XP_031751755.1, XP_017946678.1, NP_001007985.1

Xenbase

XB-GENE-6083355

Ensembl

ENSXETP00000046847, ENSXETG00000021669, ENSXETT00000046847

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