Reactome | col2a1 [extracellular region]

col2a1 [extracellular region]

Stable Identifier

R-XTR-2127427

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL2A1(182-1241), Q6P4Z2

Locations in the PathwayBrowser

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Developmental Biology (Xenopus tropicalis)

- Nervous system development (Xenopus tropicalis)
  - Axon guidance (Xenopus tropicalis)
    - NCAM signaling for neurite out-growth (Xenopus tropicalis)
      - NCAM1 interactions (Xenopus tropicalis)
        
        Interaction of NCAM1 with collagens (Xenopus tropicalis)
        
        Collagens [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type II [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)
        
        NCAM-1:Collagen complex [plasma membrane] (Xenopus tropicalis)
        
        Collagens [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type II [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)

Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Xenopus tropicalis)
    - OSCAR binds collagen and SP-D (Xenopus tropicalis)
      - Collagen types I,II,III/SP-D [extracellular region] (Xenopus tropicalis)
        
        Collagen type I, II, III, V, X fibrils [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type II [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Xenopus tropicalis)
        
        Collagen types I,II,III/SP-D [extracellular region] (Xenopus tropicalis)
        
        Collagen type I, II, III, V, X fibrils [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type II [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by MET (Xenopus tropicalis)
    - MET promotes cell motility (Xenopus tropicalis)
      - MET activates PTK2 signaling (Xenopus tropicalis)
        
        PTK2 binds activated MET (Xenopus tropicalis)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Xenopus tropicalis)
        
        Collagen, laminin, fibronectin [extracellular region] (Xenopus tropicalis)
        
        Collagen fibres [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibre [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type II [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)
        
        Collagen type XI fibre [extracellular region] (Xenopus tropicalis)
        
        Collagen type XI fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type XI [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)
  - Signaling by PDGF (Xenopus tropicalis)
    - PDGF binds to extracellular matrix proteins (Xenopus tropicalis)
      - Extracellular matrix ligands [extracellular region] (Xenopus tropicalis)
        
        Collagens [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type II [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)
      - PDGF A and B chains:ECM complex [extracellular region] (Xenopus tropicalis)
        
        Extracellular matrix ligands [extracellular region] (Xenopus tropicalis)
        
        Collagens [extracellular region] (Xenopus tropicalis)
        
        Collagen type II fibril [extracellular region] (Xenopus tropicalis)
        
        Tropocollagen type II [extracellular region] (Xenopus tropicalis)
        
        col2a1 [extracellular region] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q6P4Z2

Gene Names

col2a1

Reference Genes

BioGPS Gene:394828 col2a1

ENSEMBL:ENSXETG00000010655

ENSEMBL:ENSXETG00000019459 col2a1

KEGG Gene (Xenopus tropicalis):394828 col2a1

Monarch:394828 col2a1

NCBI Gene:394828 col2a1

Reference Transcript

RefSeq:NM_203889.1 col2a1

Other Identifiers

394828

AAH63191

BC063191

col2a1

col2a1-201

ENSXETG00000019459

ENSXETP00000052787

ENSXETT00000054222

EntrezGene:394828

EntrezGene:col2a1

GO:0001501

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005581

GO:0005615

GO:0008150

GO:0009790

GO:0030198

GO:0030199

GO:0030903

GO:0031012

GO:0032991

GO:0043167

GO:0046872

GO:0048856

IPR000885

IPR001007

IPR008160

NM_203889

NP_989220

PF00093

PF01391

PF01410

SM00038

SM00214

UPI000022627E

XM_012956661

XP_012812115

Participant Of

hasComponent

Other forms of this molecule

col2a1 [endoplasmic reticulum lumen]

col2a1 [extracellular region]

Inferred From

3x4Hyp-3Hyp-GalHyl-COL2A1(182-1241) [extracellular region] (Homo sapiens)

Collagen alpha-1(II) chains [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_989220.1

Xenbase

XB-GENE-6258353

Ensembl

ENSXETG00000019459, ENSXETP00000052787, ENSXETT00000054222