Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
crk [cytosol]
Stable Identifier
R-XTR-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
CRK, Q6GLF5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
Signaling by Non-Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by PTK6 (Xenopus tropicalis)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Xenopus tropicalis)
Activation of RAC1 by the PXN:CRK complex (Xenopus tropicalis)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by MET (Xenopus tropicalis)
MET promotes cell motility (Xenopus tropicalis)
MET activates RAP1 and RAC1 (Xenopus tropicalis)
CRK,CRKL recruits RAC1 GEF to activated MET (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
DOCK7 activates RAC1 (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
RAPGEF1 activates RAP1 (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
RAPGEF1 binds CRK,CRKL (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
MET receptor recycling (Xenopus tropicalis)
GGA3 associates with activated MET receptor (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
Signaling by NTRKs (Xenopus tropicalis)
Signaling by NTRK1 (TRKA) (Xenopus tropicalis)
Signalling to ERKs (Xenopus tropicalis)
Prolonged ERK activation events (Xenopus tropicalis)
ARMS-mediated activation (Xenopus tropicalis)
ARMS is phosphorylated by active TrkA receptor (Xenopus tropicalis)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Xenopus tropicalis)
ARMS:Crk [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Xenopus tropicalis)
Phospho-ARMS:Crk [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
C3G stimulates nucleotide exchange on Rap1 (Xenopus tropicalis)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Xenopus tropicalis)
Phospho-ARMS:Crk [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
Crk's SH3 domain engages C3G (Xenopus tropicalis)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Xenopus tropicalis)
Phospho-ARMS:Crk [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
Signaling by PDGF (Xenopus tropicalis)
Downstream signal transduction (Xenopus tropicalis)
Crk binds to the active PDGF receptor (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
p130Cas and C3G bind PDGFR bound Crk (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Xenopus tropicalis)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
Signaling by VEGF (Xenopus tropicalis)
VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
DOCK180:ELMO binds CRK (Xenopus tropicalis)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Xenopus tropicalis)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Xenopus tropicalis)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
crk [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:Q6GLF5
Gene Names
crk
Reference Genes
BioGPS Gene:448023 crk
ENSEMBL:ENSXETG00000022904
KEGG Gene (Xenopus tropicalis):448023 crk
Monarch:448023 crk
NCBI Gene:448023 crk
Reference Transcript
RefSeq:NM_001006107.1 crk
Other Identifiers
448023
GO:0005515
GO:0048870
GO:2000145
Participates
as an input of
Crk binds to the active PDGF receptor (Xenopus tropicalis)
GAB1 recruits CRK,CRKL to MET (Xenopus tropicalis)
as a component of
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Xenopus tropicalis)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Xenopus tropicalis)
Phospho-ARMS:Crk [cytosol] (Xenopus tropicalis)
ARMS:Crk [cytosol] (Xenopus tropicalis)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Xenopus tropicalis)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
Inferred From
CRK, CRKL [cytosol]
(Homo sapiens)
CRK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001006107.1
Xenbase
XB-GENE-996357
Ensembl
ENSXETT00000099931
,
ENSXETG00000022904
,
ENSXETP00000099598
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
