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gsk3b [cytosol]
Stable Identifier
R-XTR-2997551
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
cytosol
Synonyms
GSK3B, F7ACT4
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to heat stress (Xenopus tropicalis)
Regulation of HSF1-mediated heat shock response (Xenopus tropicalis)
Constitutive phosphorylation by GSK3 (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Developmental Biology (Xenopus tropicalis)
Nervous system development (Xenopus tropicalis)
Axon guidance (Xenopus tropicalis)
Semaphorin interactions (Xenopus tropicalis)
CRMPs in Sema3A signaling (Xenopus tropicalis)
Phosphorylation of CRMPs by GSK3beta (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Signal Transduction (Xenopus tropicalis)
Signaling by Hedgehog (Xenopus tropicalis)
Hedgehog 'off' state (Xenopus tropicalis)
GLI3 is processed to GLI3R by the proteasome (Xenopus tropicalis)
GSK3 phosphorylates p-GLI3 (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Signaling by WNT (Xenopus tropicalis)
Degradation of beta-catenin by the destruction complex (Xenopus tropicalis)
AXIN is phosphorylated in the destruction complex (Xenopus tropicalis)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Assembly of the destruction complex (Xenopus tropicalis)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Association of beta-catenin with the destruction complex (Xenopus tropicalis)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Beta-catenin phosphorylation cascade (Xenopus tropicalis)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Xenopus tropicalis)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Xenopus tropicalis)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Xenopus tropicalis)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Xenopus tropicalis)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Xenopus tropicalis)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Xenopus tropicalis)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Phosphorylation of APC component of the destruction complex (Xenopus tropicalis)
CK1alpha (GSK3) [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
TCF dependent signaling in response to WNT (Xenopus tropicalis)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Xenopus tropicalis)
Beta-catenin is released from the destruction complex (Xenopus tropicalis)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Xenopus tropicalis)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Xenopus tropicalis)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Xenopus tropicalis)
GSK3B:AXIN1 [cytosol] (Xenopus tropicalis)
gsk3b [cytosol] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:F7ACT4
Gene Names
gsk3b
Reference Genes
ENSEMBL:ENSXETG00000018019
ENSEMBL:ENSXETG00000027883 gsk3b
Other Identifiers
100489648
GO:0003674
GO:0004672
GO:0004674
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0006464
GO:0006468
GO:0007010
GO:0007015
GO:0007165
GO:0007267
GO:0008013
GO:0008064
GO:0008150
GO:0008219
GO:0008286
GO:0010975
GO:0016301
GO:0030154
GO:0030424
GO:0030877
GO:0031209
GO:0032991
GO:0040011
GO:0043167
GO:0043226
GO:0044877
GO:0048856
GO:0048870
GO:0050321
GO:0070507
GO:0090090
GO:0097192
GO:0098978
Str.35858.1.A1_at
Participant Of
hasComponent
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
GSK3B:AXIN1 [cytosol]
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]
input
Assembly of the destruction complex
hasCandidate
CK1alpha (GSK3) [cytosol]
Inferred From
GSK3B [cytosol] (Homo sapiens)
Cross References
Ensembl
ENSXETT00000039075
,
ENSXETG00000018019
,
ENSXETP00000039075
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