Reactome | MCM8 [nucleoplasm]

MCM8 [nucleoplasm]

Stable Identifier

R-XTR-3006646

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

Q0V9Q6

Locations in the PathwayBrowser

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Cell Cycle (Xenopus tropicalis)

- Cell Cycle, Mitotic (Xenopus tropicalis)
  - Mitotic G1 phase and G1/S transition (Xenopus tropicalis)
    - G1/S Transition (Xenopus tropicalis)
      - Activation of the pre-replicative complex (Xenopus tropicalis)
        
        Cdt1 is displaced from the pre-replicative complex (Xenopus tropicalis)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM10:pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        DNA polymerase epsilon binds at the origin (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Xenopus tropicalis)
        
        MCM10:pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
  - S Phase (Xenopus tropicalis)
    - Synthesis of DNA (Xenopus tropicalis)
      - Switching of origins to a post-replicative state (Xenopus tropicalis)
        
        Orc1 removal from chromatin (Xenopus tropicalis)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)

DNA Replication (Xenopus tropicalis)

- DNA Replication Pre-Initiation (Xenopus tropicalis)
  - Activation of the pre-replicative complex (Xenopus tropicalis)
    - Cdt1 is displaced from the pre-replicative complex (Xenopus tropicalis)
      - MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
      - MCM10:pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Xenopus tropicalis)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
    - DNA polymerase epsilon binds at the origin (Xenopus tropicalis)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Xenopus tropicalis)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        active pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
    - Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Xenopus tropicalis)
      - MCM10:pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
      - pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
  - Assembly of the pre-replicative complex (Xenopus tropicalis)
    - CDC6 association with the ORC:origin complex (Xenopus tropicalis)
      - CDC6 association with ORC(1-6) at replication origins (Xenopus tropicalis)
        
        CDC6:MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
      - MCM8 binds CDC6 (Xenopus tropicalis)
        
        CDC6:MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
- Synthesis of DNA (Xenopus tropicalis)
  - Switching of origins to a post-replicative state (Xenopus tropicalis)
    - Orc1 removal from chromatin (Xenopus tropicalis)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Xenopus tropicalis)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        pre-replicative complex [nucleoplasm] (Xenopus tropicalis)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        CDC6:ORC:origin complex [nucleoplasm] (Xenopus tropicalis)
        
        ORC:origin of replication [nucleoplasm] (Xenopus tropicalis)
        
        Orc2 associated with MCM8 [nucleoplasm] (Xenopus tropicalis)
        
        MCM8 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q0V9Q6

Reference Genes

BioGPS Gene:779797

ENSEMBL:ENSXETG00000004500

KEGG:xtr:779797

Monarch:779797

NCBI Gene:779797

UCSC:Q0V9Q6

Reference Transcript

RefSeq:NM_001078876.1

Other Identifiers

779797

GO:0003677

GO:0003824

GO:0005524

GO:0005634

GO:0006260

GO:0016787

GO:0016887

GO:0030174

GO:0032508

GO:0042555

GO:0043226

Participates

as an input of

MCM8 binds CDC6 (Xenopus tropicalis)

as a component of

Inferred From

MCM8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001072344.1

ENSEMBL

ENSXETG00000004500, ENSXETT00000061843, ENSXETP00000060047

Xenbase

XB-GENE-961372

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