Reactome | rptor [cytosol]

rptor [cytosol]

Stable Identifier

R-XTR-3006727

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

RPTOR, A0A6I8RIN4

Locations in the PathwayBrowser

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Autophagy (Xenopus tropicalis)

- Macroautophagy (Xenopus tropicalis)
  - Active MTORC1 binds the ULK1 complex (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
  - Active MTORC1 phosphorylates ULK1 (Xenopus tropicalis)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
  - Rheb in the MTORC1 complex hydrolyses GTP (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)

Cellular responses to stimuli (Xenopus tropicalis)

- Cellular responses to stress (Xenopus tropicalis)
  - Cellular response to starvation (Xenopus tropicalis)
    - Amino acids regulate mTORC1 (Xenopus tropicalis)
      - RRAGA,B hydrolyzes GTP (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
      - mTORC1 binds RHEB:GTP (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Xenopus tropicalis)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)

Gene expression (Transcription) (Xenopus tropicalis)

- RNA Polymerase II Transcription (Xenopus tropicalis)
  - Generic Transcription Pathway (Xenopus tropicalis)
    - Transcriptional Regulation by TP53 (Xenopus tropicalis)
      - TP53 Regulates Metabolic Genes (Xenopus tropicalis)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)
        
        Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)

Signal Transduction (Xenopus tropicalis)

- MTOR signalling (Xenopus tropicalis)
  - AKT1S1 (PRAS40) binds mTORC1 (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Xenopus tropicalis)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
  - Formation of active mTORC1 complex (Xenopus tropicalis)
    - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Xenopus tropicalis)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Xenopus tropicalis)
      - Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Xenopus tropicalis)
        
        Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
  - mTORC1 phosphorylates AKT1S1 (Xenopus tropicalis)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Xenopus tropicalis)
        
        Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Xenopus tropicalis)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Xenopus tropicalis)
        
        Active mTORC1 complex [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Xenopus tropicalis)
        
        mTORC1 [cytosol] (Xenopus tropicalis)
        
        rptor [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8RIN4

Gene Names

rptor

Reference Genes

BioGPS Gene:100170605 rptor

ENSEMBL:ENSXETG00000013410

Monarch:100170605 rptor

NCBI Gene:100170605 rptor

Reference Transcript

RefSeq:XM_012971553.2 rptor

Other Identifiers

100170605

GO:0005515

GO:0023052

GO:0031929

GO:0031931

Participates

as a component of

mTORC1 [cytosol] (Xenopus tropicalis)

Other forms of this molecule

phospho-rptor [cytosol]

Inferred From

RPTOR [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_012827007.1

Ensembl

ENSXETT00000094910, ENSXETP00000084740, ENSXETG00000013410

Xenbase

XB-GENE-1012818

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