Reactome | elmo2 [cytosol]

elmo2 [cytosol]

Stable Identifier

R-XTR-372642

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

ELMO2, A0A6I8S2K7

Locations in the PathwayBrowser

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Signal Transduction (Xenopus tropicalis)

- Signaling by Non-Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by PTK6 (Xenopus tropicalis)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Xenopus tropicalis)
      - Activation of RAC1 by the PXN:CRK complex (Xenopus tropicalis)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        elmo2 [cytosol] (Xenopus tropicalis)
- Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
  - Signaling by VEGF (Xenopus tropicalis)
    - VEGFA-VEGFR2 Pathway (Xenopus tropicalis)
      - DOCK180:ELMO binds CRK (Xenopus tropicalis)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Xenopus tropicalis)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        elmo2 [cytosol] (Xenopus tropicalis)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        elmo2 [cytosol] (Xenopus tropicalis)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Xenopus tropicalis)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        elmo2 [cytosol] (Xenopus tropicalis)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Xenopus tropicalis)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)
        
        elmo2 [cytosol] (Xenopus tropicalis)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Xenopus tropicalis)
  - Signaling by Rho GTPases (Xenopus tropicalis)
    - RHO GTPase cycle (Xenopus tropicalis)
      - RHOG GTPase cycle (Xenopus tropicalis)
        
        RHOG binds effectors at the plasma membrane (Xenopus tropicalis)
        
        RHOG plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        elmo2 [cytosol] (Xenopus tropicalis)
        
        RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Xenopus tropicalis)
        
        RHOG plasma membrane effectors [cytosol] (Xenopus tropicalis)
        
        elmo2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A6I8S2K7

Gene Names

elmo2

Reference Genes

BioGPS Gene:493485 elmo2

ENSEMBL:ENSXETG00000007361

Monarch:493485 elmo2

NCBI Gene:493485 elmo2

UCSC:A0A6I8S2K7 elmo2

Reference Transcript

Other Identifiers

493485

GO:0006909

GO:0006915

GO:0012501

GO:0016192

GO:0017124

Participates

as a candidate of

RHOG plasma membrane effectors [cytosol] (Xenopus tropicalis)

as a member of

ELMO1,ELMO2 [cytosol] (Xenopus tropicalis)

Inferred From

ELMO2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_031749909.1, XP_012827131.1, XP_012827134.1, XP_012827132.1, XP_012827130.1, XP_012827133.1, XP_017953202.1

ENSEMBL

ENSXETT00000079335, ENSXETP00000091102

Xenbase

XB-GENE-986985