Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
VBC complex [cytosol]
Stable Identifier
R-XTR-390483
Type
Complex
Species
Xenopus tropicalis
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to hypoxia (Xenopus tropicalis)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Xenopus tropicalis)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Proteasome proteolyzes ub-HIF-alpha (Xenopus tropicalis)
VBC complex (with or without LIMD1) [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Xenopus tropicalis)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Class I MHC mediated antigen processing & presentation (Xenopus tropicalis)
Antigen processing: Ubiquitination & Proteasome degradation (Xenopus tropicalis)
Interaction of E3 with substrate and E2-Ub complex (Xenopus tropicalis)
Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Polyubiquitination of substrate (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
E3:Ub:substrate [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Release of E3 from polyubiquitinated substrate (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
E3:K48-polyubiquitinated substrate [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Transfer of Ub from E2 to substrate and release of E2 (Xenopus tropicalis)
Ag-substrate:E3:E2:Ub [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
E3:Ub:substrate [cytosol] (Xenopus tropicalis)
E3 ligases in proteasomal degradation [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
Metabolism of proteins (Xenopus tropicalis)
Post-translational protein modification (Xenopus tropicalis)
Neddylation (Xenopus tropicalis)
26S proteasome degrades HIFalpha (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
VBC complex [cytosol] (Xenopus tropicalis)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
elob [cytosol]
(Xenopus tropicalis)
eloc [cytosol]
(Xenopus tropicalis)
Ghost homologue of VHL [cytosol]
(Xenopus tropicalis)
Participates
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Xenopus tropicalis)
RBX1-CUL2-EloB,C-VHL [cytosol] (Xenopus tropicalis)
Inferred From
VBC complex [cytosol]
(Homo sapiens)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
