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phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
Stable Identifier
R-XTR-5672665
Type
Protein [EntityWithAccessionedSequence]
Species
Xenopus tropicalis
Compartment
plasma membrane
Synonyms
F6RZI1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Xenopus tropicalis)
MAPK family signaling cascades (Xenopus tropicalis)
MAPK1/MAPK3 signaling (Xenopus tropicalis)
RAF/MAP kinase cascade (Xenopus tropicalis)
MAP2K and MAPK activation (Xenopus tropicalis)
Dissociation of RAS:RAF complex (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
Dual mechanism MAPK inhibitors bind MAPKs (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
MAP2Ks and MAPKs bind to the activated RAF complex (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
MAP2Ks phosphorylate MAPKs (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
RAF phosphorylates MAP2K dimer (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Xenopus tropicalis)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
Negative regulation of MAPK pathway (Xenopus tropicalis)
Negative feedback regulation of MAPK pathway (Xenopus tropicalis)
Activated MAPK phosphorylates RAF1 (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
PEBP1 binds activated RAF1 (Xenopus tropicalis)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
PP5 dephosphorylates RAF1 S338 (Xenopus tropicalis)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
RAF activation (Xenopus tropicalis)
Phosphorylation of RAF (Xenopus tropicalis)
RAF activating kinases [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Xenopus tropicalis)
activated RAF/KSR1 [plasma membrane] (Xenopus tropicalis)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Xenopus tropicalis)
External Reference Information
External Reference
UniProt:F6RZI1
Reference Genes
ENSEMBL:ENSXETG00000020163
Other Identifiers
100486469
GO:0003674
GO:0004672
GO:0005524
GO:0006464
GO:0006468
GO:0008150
GO:0016301
GO:0043167
Participant Of
input
Activated MAPK phosphorylates RAF1
hasCandidate
RAF activating kinases [plasma membrane]
hasComponent
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane]
hasMember
activated RAF/KSR1 [plasma membrane]
Other forms of this molecule
RAF1 [cytosol]
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
phospho-p-S338-RAF1 [cytosol]
phospho-hyperphosphorylated RAF1 [plasma membrane]
phospho-p-S621-RAF1 [plasma membrane]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S259,S621-RAF1 [cytosol]
phospho-p-S621-RAF1 [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
Inferred From
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 621 (in Homo sapiens)
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341 (in Homo sapiens)
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338 (in Homo sapiens)
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491 (in Homo sapiens)
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494 (in Homo sapiens)
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
Ensembl
ENSXETG00000004324
,
ENSXETT00000094000
,
ENSXETP00000083286
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