Reactome | phospho-h2az2 [nucleoplasm]

phospho-h2az2 [nucleoplasm]

Stable Identifier

R-XTR-5683953

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

p-S140,Y143-H2AFX, A0A5S6JZR0

Locations in the PathwayBrowser

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DNA Repair (Xenopus tropicalis)

- DNA Double-Strand Break Repair (Xenopus tropicalis)
  - DNA Double Strand Break Response (Xenopus tropicalis)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Xenopus tropicalis)
      - APBB1 and MAPK8 bind diphosphorylated H2AFX (Xenopus tropicalis)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        Homologues of p-S140,Y143-H2AFX [nucleoplasm] (Xenopus tropicalis)
        
        phospho-h2az2 [nucleoplasm] (Xenopus tropicalis)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Xenopus tropicalis)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        Homologues of p-S140,Y143-H2AFX [nucleoplasm] (Xenopus tropicalis)
        
        phospho-h2az2 [nucleoplasm] (Xenopus tropicalis)
      - ATM phosphorylates EYA1-4 (Xenopus tropicalis)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        Homologues of p-S140,Y143-H2AFX [nucleoplasm] (Xenopus tropicalis)
        
        phospho-h2az2 [nucleoplasm] (Xenopus tropicalis)
      - ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Xenopus tropicalis)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        Homologues of p-S140,Y143-H2AFX [nucleoplasm] (Xenopus tropicalis)
        
        phospho-h2az2 [nucleoplasm] (Xenopus tropicalis)
      - EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Xenopus tropicalis)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Xenopus tropicalis)
        
        Homologues of p-S140,Y143-H2AFX [nucleoplasm] (Xenopus tropicalis)
        
        phospho-h2az2 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:A0A5S6JZR0

Gene Names

h2az2

Reference Genes

ENSEMBL:ENSXETG00000001258

Other Identifiers

548932

GO:0000786

GO:0003677

GO:0005198

GO:0005622

GO:0005634

GO:0005694

GO:0005856

GO:0005882

GO:0030527

GO:0032991

GO:0043226

GO:0046982

Participates

as a member of

Homologues of p-S140,Y143-H2AFX [nucleoplasm] (Xenopus tropicalis)

Other forms of this molecule

h2az2 [nucleoplasm]

phospho-h2az2 [nucleoplasm]

h2az2 [nucleoplasm]

Inferred From

p-S140,Y143-H2AFX [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 140 (in Homo sapiens)

Coordinate

140

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 143 (in Homo sapiens)

Coordinate

143

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Ensembl

ENSXETT00000002709, ENSXETP00000002709, ENSXETG00000001258