Reactome | phospho-rad51 [nucleoplasm]

phospho-rad51 [nucleoplasm]

Stable Identifier

R-XTR-5685231

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

nucleoplasm

Synonyms

p-T309-RAD51, F6ZKW7

Locations in the PathwayBrowser

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DNA Repair (Xenopus tropicalis)

- DNA Double-Strand Break Repair (Xenopus tropicalis)
  - Homology Directed Repair (Xenopus tropicalis)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Xenopus tropicalis)
      - HDR through Homologous Recombination (HRR) (Xenopus tropicalis)
        
        D-loop extension by DNA polymerases (Xenopus tropicalis)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Homologous DNA Pairing and Strand Exchange (Xenopus tropicalis)
        
        CX3 complex binds D-loop structures (Xenopus tropicalis)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Xenopus tropicalis)
        
        BCDX2 complex stabilizes RAD51 filament (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        CHEK1 phosphorylates RAD51 (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Xenopus tropicalis)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Resolution of D-Loop Structures (Xenopus tropicalis)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Xenopus tropicalis)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Xenopus tropicalis)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Xenopus tropicalis)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        MUS81:EME1,EME2 cleaves D-loop (Xenopus tropicalis)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Xenopus tropicalis)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Xenopus tropicalis)
        
        p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm] (Xenopus tropicalis)
        
        phospho-rad51 [nucleoplasm] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F6ZKW7

Gene Names

rad51

Reference Genes

ENSEMBL:ENSXETG00000015951

Other Identifiers

549147

GO:0000003

GO:0000150

GO:0000166

GO:0000228

GO:0000278

GO:0000724

GO:0000730

GO:0000794

GO:0002376

GO:0003674

GO:0003677

GO:0003690

GO:0003697

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0006259

GO:0006281

GO:0006312

GO:0006810

GO:0006886

GO:0006950

GO:0007049

GO:0007131

GO:0008094

GO:0008150

GO:0008283

GO:0009058

GO:0010212

GO:0015031

GO:0016020

GO:0016887

GO:0022607

GO:0034641

GO:0042148

GO:0043167

GO:0043226

GO:0046686

GO:0048856

GO:0051276

GO:0051597

GO:0065003

GO:0070192

GO:0071425

GO:1990426

Str.26955.1.S1_at

Participant Of

input

RAD51 binds BRCA2 at resected DNA DSBs

output

CHEK1 phosphorylates RAD51

hasComponent

p-T3387-BRCA2:p-T309-RAD51 complex [nucleoplasm]

Other forms of this molecule

rad51 [nucleoplasm]

Inferred From

p-T309-RAD51 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 309 (in Homo sapiens)

Coordinate

309

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

Ensembl

ENSXETT00000034829, ENSXETP00000034829, ENSXETG00000015951

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