Reactome | mcfd2 [endoplasmic reticulum membrane]

mcfd2 [endoplasmic reticulum membrane]

Stable Identifier

R-XTR-5689470

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

endoplasmic reticulum membrane

Synonyms

MCFD2, F7ELI4

Locations in the PathwayBrowser

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Metabolism of proteins (Xenopus tropicalis)

- Post-translational protein modification (Xenopus tropicalis)
  - Asparagine N-linked glycosylation (Xenopus tropicalis)
    - Transport to the Golgi and subsequent modification (Xenopus tropicalis)
      - ER to Golgi Anterograde Transport (Xenopus tropicalis)
        
        COPII-mediated vesicle transport (Xenopus tropicalis)
        
        Inner coat assembly and cargo binding (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        Loss of SAR1B GTPase (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        SEC31:SEC13 and v-SNARE recruitment (Xenopus tropicalis)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        Cargo concentration in the ER (Xenopus tropicalis)
        
        Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        Inner coat assembly and cargo binding (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Vesicle-mediated transport (Xenopus tropicalis)

- Membrane Trafficking (Xenopus tropicalis)
  - ER to Golgi Anterograde Transport (Xenopus tropicalis)
    - COPII-mediated vesicle transport (Xenopus tropicalis)
      - Inner coat assembly and cargo binding (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
      - Loss of SAR1B GTPase (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
      - SEC31:SEC13 and v-SNARE recruitment (Xenopus tropicalis)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
    - Cargo concentration in the ER (Xenopus tropicalis)
      - Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
      - Inner coat assembly and cargo binding (Xenopus tropicalis)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        LMAN1:MCFD2:glycosylated FV, FVIII precursor [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane] (Xenopus tropicalis)
        
        mcfd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:F7ELI4

Gene Names

mcfd2

Reference Genes

ENSEMBL:ENSXETG00000001797 mcfd2

ENSEMBL:ENSXETG00000022745

Other Identifiers

100488055

CACNA1C

cacna1c

CACNA1C-203

ENSXETG00000001797

ENSXETP00000049208

ENSXETT00000050595

EntrezGene:100488055

EntrezGene:cacna1c

GO:0003674

GO:0005216

GO:0005245

GO:0005509

GO:0005575

GO:0005623

GO:0005886

GO:0005891

GO:0006810

GO:0006811

GO:0008150

GO:0016020

GO:0022857

GO:0032991

GO:0043167

GO:0055085

GO:0070588

HGNC:1390

IPR002077

IPR005446

IPR005451

IPR005821

IPR014873

IPR027359

IPR031649

IPR031688

PF00520

PF08763

PF16885

PF16905

PR00167

PR01630

PR01635

SM01062

XM_004912486

XP_004912543

Participant Of

hasComponent

hexameric LMAN1:MCFD2 [endoplasmic reticulum membrane]

Other forms of this molecule

mcfd2 [endoplasmic reticulum-Golgi intermediate compartment membrane]

mcfd2 [ER to Golgi transport vesicle membrane]

Inferred From

MCFD2 [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

Xenbase

XB-GENE-981596

Ensembl

ENSXETG00000001797, ENSXETT00000050595, ENSXETP00000049208