Reactome | RPL40 [cytosol]

RPL40 [cytosol]

Stable Identifier

R-XTR-72476

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

Q6AZL4

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        RPL40 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q6AZL4

Reference Genes

BioGPS Gene:448705

dbSNP Gene:448705

ENSEMBL:ENSXETG00000023202

KEGG Gene (Xenopus tropicalis):448705

Monarch:448705

NCBI Gene:448705

Reference Transcript

Other Identifiers

448705

AAH77658

AAMC01101034

BC077658

CAJ83027

CR760443

ENSXETG00000023202

ENSXETP00000050158

ENSXETT00000050158

EntrezGene:448705

EntrezGene:uba52

GO:0003674

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006464

GO:0008150

GO:0009056

GO:0009058

GO:0016567

GO:0019899

GO:0019941

GO:0022627

GO:0031386

GO:0031625

GO:0032991

GO:0034641

GO:0043226

IPR000626

IPR001975

IPR019954

IPR019956

IPR029071

IPR038587

NM_001005123

NP_001005123

PF00240

PF01020

PR00348

SM00213

SM01377

Str.6314.1.S1_a_at

uba52

uba52-201

UPI0000021092

XB-GENE-939925

XM_012964544

XP_012819998

XP_017947893

Participant Of

hasComponent

output

UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

Other forms of this molecule

UBA52(1-76) [endocytic vesicle membrane]

Ub-33-UBA52(1-76) [mitochondrial outer membrane]

Ub-63-UBA52(1-76) [mitochondrial outer membrane]

Ub-6-UBA52(1-76) [mitochondrial outer membrane]

Ub-11-UBA52(1-76) [mitochondrial outer membrane]

Ub-63-UBA52(1-76) [cytosol]

UBA52(1-76) [cytosol]

Ub-48-UBA52(1-76) [cytosol]

Ub-63-UBA52(1-76) [nucleoplasm]

UBA52(1-76) [nucleoplasm]

Ub-6-UBA52(1-76) [nucleoplasm]

Ub-33-UBA52(1-76) [nucleoplasm]

Ub-11-UBA52(1-76) [nucleoplasm]

Ub-48-UBA52(1-76) [nucleoplasm]

Ub-29-UBA52(1-76) [nucleoplasm]

Ub-27-UBA52(1-76) [nucleoplasm]

Ub-11-UBA52(1-76) [cytosol]

Ub-27-UBA52(1-76) [cytosol]

UBA52(1-76) [endosome membrane]

phospho-adenylatedG76-UBA52(1-76) [cytosol]

UBA52(1-128) [cytosol]

phospho-adenylatedG76-UBA52(1-76) [nucleoplasm]

Ub-33-UBA52(1-76) [cytosol]

Ub-6-UBA52(1-76) [cytosol]

Ub-29-UBA52(1-76) [cytosol]

N6-glycyl-L-lysine-UBA52(1-76) [cytosol]

Ub-27-UBA52(1-76) [mitochondrial outer membrane]

Ub-29-UBA52(1-76) [mitochondrial outer membrane]

Ub-48-UBA52(1-76) [mitochondrial outer membrane]

Inferred From

RPL40 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017947893.1, XP_012819998.1, NP_001005123.1