Reactome | uba52 [cytosol]

uba52 [cytosol]

Stable Identifier

R-XTR-72476

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

RPL40, Q6AZL4

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        uba52 [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        uba52 [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        uba52 [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        uba52 [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        uba52 [cytosol] (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        uba52 [cytosol] (Xenopus tropicalis)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        80S ribosome [cytosol] (Xenopus tropicalis)
        
        60S ribosomal complex [cytosol] (Xenopus tropicalis)
        
        uba52 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:Q6AZL4

Gene Names

uba52

Reference Genes

BioGPS Gene:448705 uba52

ENSEMBL:ENSXETG00000004009 uba52

ENSEMBL:ENSXETG00000023202

KEGG Gene (Xenopus tropicalis):448705 uba52

Monarch:448705 uba52

NCBI Gene:448705 uba52

Reference Transcript

Other Identifiers

100493467

GO:0000124

GO:0003674

GO:0003713

GO:0003735

GO:0005198

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005669

GO:0005737

GO:0005829

GO:0005840

GO:0006325

GO:0006352

GO:0006357

GO:0006367

GO:0006412

GO:0006464

GO:0008150

GO:0009056

GO:0009058

GO:0015935

GO:0016251

GO:0016567

GO:0019899

GO:0019941

GO:0022607

GO:0022627

GO:0031386

GO:0031625

GO:0032991

GO:0034641

GO:0043226

GO:0046695

GO:0046982

GO:0051123

GO:0051276

GO:0060261

GO:0065003

Participant Of

hasComponent

output

UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

Other forms of this molecule

uba52 [endocytic vesicle membrane]

uba52 [mitochondrial outer membrane]

uba52 [cytosol]

phospho-uba52 [nucleoplasm]

uba52 [cytosol]

phospho-uba52 [cytosol]

uba52 [nucleoplasm]

uba52 [endosome membrane]

uba52 [cytosol]

uba52 [nucleoplasm]

uba52 [cytosol]

Inferred From

RPL40 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001005123.1, XP_012819998.1, XP_017947893.1

Target Pathogen

5b354852be737e166372eb5f, 5b2801b2be737e35a6de9e91, 5b354852be737e166372eb07, 5b2801b3be737e35a6deded6, 5b2801b2be737e35a6de9681, 57c5e0e8be737e5a0cb48b62

Ensembl

ENSXETG00000004009, ENSXETP00000008691, ENSXETT00000008691

Cite Us!