Reactome | upf2 [cytosol]

upf2 [cytosol]

Stable Identifier

R-XTR-927799

Type

Protein [EntityWithAccessionedSequence]

Species

Xenopus tropicalis

Compartment

cytosol

Synonyms

UPF2, B2GUE8

Locations in the PathwayBrowser

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Metabolism of RNA (Xenopus tropicalis)

- Nonsense-Mediated Decay (NMD) (Xenopus tropicalis)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Xenopus tropicalis)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        upf2 [cytosol] (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        upf2 [cytosol] (Xenopus tropicalis)
    - SMG6 hydrolyzes mRNA with premature termination codon (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        upf2 [cytosol] (Xenopus tropicalis)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Xenopus tropicalis)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        upf2 [cytosol] (Xenopus tropicalis)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        upf2 [cytosol] (Xenopus tropicalis)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Xenopus tropicalis)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        upf2 [cytosol] (Xenopus tropicalis)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Xenopus tropicalis)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Xenopus tropicalis)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)
        
        upf2 [cytosol] (Xenopus tropicalis)

External Reference Information

External Reference

UniProt:B2GUE8

Gene Names

upf2

Reference Genes

BioGPS Gene:100158573 upf2

ENSEMBL:ENSXETG00000033103

KEGG Gene (Xenopus tropicalis):100158573 upf2

Monarch:100158573 upf2

NCBI Gene:100158573 upf2

Reference Transcript

Other Identifiers

100158573

GO:0000184

GO:0003723

GO:0005515

GO:0005737

GO:0016071

Participates

as a component of

Exon Junction:UPF2:UPF3 Complex [cytosol] (Xenopus tropicalis)

Inferred From

UPF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001121475.1, XP_012814093.1, XP_012814093.2

Ensembl

ENSXETT00000102440, ENSXETP00000088620, ENSXETG00000033103

Xenbase

XB-GENE-6454322