viral dsRNA binds the toll-like receptor 3 (TLR3)

Stable Identifier
Reaction [binding]
Gallus gallus
Related Species
Infectious bronchitis virus
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Viral dsRNA triggers an antiviral pathway mediated by toll like receptor 3. TLR3 dimerization occurs upon ligand binding to positivly charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA.

Literature References
PubMed ID Title Journal Year
25378498 Activation of the chicken type I interferon response by infectious bronchitis coronavirus

Forlenza, M, Maier, HJ, Langereis, MA, Koumans, J, Fernandez-Gutierrez, M, Wiegertjes, GF, Britton, P, Kint, J

J. Virol. 2015
17316136 Chicken toll-like receptor 3 recognizes its cognate ligand when ectopically expressed in human cells

Staeheli, P, Bauer, S, Ohnemus, A, Kaspers, B, Kothlow, S, Lavric, M, Schwarz, H, Schneider, K

J Interferon Cytokine Res 2007
18420935 Structural basis of toll-like receptor 3 signaling with double-stranded RNA

Davies, DR, Leonard, JN, Shiloach, J, Botos, I, Liu, L, Wang, Y, Segal, DM

Science 2008
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