MyD88 dependent cascade initiated on endosome

Stable Identifier
R-HSA-975155
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus, Human immunodeficiency virus 1, Human SARS coronavirus
Compartment
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Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Literature References
PubMed ID Title Journal Year
20237413 Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance

Cherfils-Vicini, J, Saut├Ęs-Fridman, C, Gillard, M, Damotte, D, Validire, P, Fridman, WH, Dieu-Nosjean, MC, Platonova, S, Cremer, I, Laurans, L, Mami-Chouaib, F, Caliandro, R, Magdeleinat, P

J. Clin. Invest. 2010
15276183 MD-2: the Toll 'gatekeeper' in endotoxin signalling

Gay, NJ, Gangloff, M

Trends Biochem Sci 2004
18652679 Comparison of human B cell activation by TLR7 and TLR9 agonists

Lipson, KE, Hanten, JA, Riter, CL, Birmachu, W, Neys, L, Vasilakos, JP, Alkan, SS

BMC Immunol. 2008
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Orthologous Events
Cross References
BioModels Database
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