Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.
Cherfils-Vicini, J, Sautès-Fridman, C, Gillard, M, Damotte, D, Validire, P, Fridman, WH, Dieu-Nosjean, MC, Platonova, S, Cremer, I, Laurans, L, Mami-Chouaib, F, Caliandro, R, Magdeleinat, P
Gay, NJ, Gangloff, M
Lipson, KE, Hanten, JA, Riter, CL, Birmachu, W, Neys, L, Vasilakos, JP, Alkan, SS
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