Reactome | UniProt:P00533 EGFR

UniProt:P00533 EGFR

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

EGFR_HUMAN, O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5

List of interactors in Reactome

Interactors (85)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P00533	2	EGFR [plasma membrane] (R-HSA-179837) EGFRvIII [plasma membrane] (R-HSA-1214162)	0.978	26
P62993	1	GRB2 [cytosol] (R-HSA-8983328)	0.978	47
P29353	2	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680)	0.97	37
P22681	3	CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.964	26
P04626	1	ERBB2 [plasma membrane] (R-HSA-372889)	0.96	25
P01133	2	EGF [extracellular region] (R-HSA-179863) Pro-EGF [plasma membrane] (R-HSA-179888)	0.957	21
P40763	5	p-S727-STAT3 [cytosol] (R-HSA-198705) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044)	0.893	14
P12931	5	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y416-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701)	0.863	8
P19174	4	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682)	0.85	6
P08238	1	HSP90AB1 [cytosol] (R-HSA-419617)	0.839	8
P18031	1	PTPN1 [cytosol] (R-HSA-210625)	0.822	7
P20417	1	PTPN1 [cytosol] (R-RNO-210625)	0.802	11
P08581	1	MET [plasma membrane] (R-HSA-419603)	0.8	8
P27986	1	PIK3R1 [cytosol] (R-HSA-74789)	0.779	6
P31947	1	SFN [cytosol] (R-HSA-1445105)	0.779	8
P07948	4	LYN [cytosol] (R-HSA-354251) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y396-LYN [plasma membrane] (R-HSA-2454229)	0.763	6
Q9UBN7	2	HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [nucleoplasm] (R-HSA-351589)	0.753	11
Q03135	3	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [plasma membrane] (R-HSA-534994)	0.752	6
Q05209	1	PTPN12 [cytosol] (R-HSA-432933)	0.747	4
P16885	6	p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [cytosol] (R-HSA-1604645) PLCG2 [plasma membrane] (R-HSA-114601)	0.744	5
P10599	4	2xHC-TXN [cytosol] (R-HSA-73668) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [cytosol] (R-HSA-66000) TXN [nucleoplasm] (R-HSA-9617732)	0.721	4
P11142	5	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.716	5
P42224	4	p-STAT1 [cytosol] (R-HSA-8950418) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [cytosol] (R-HSA-8951202) STAT1 [cytosol] (R-HSA-629622)	0.706	6
P16333	1	NCK1 [cytosol] (R-HSA-197954)	0.704	4
Q06124	2	PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745)	0.704	5
P04083	1	ANXA1 [cytosol] (R-HSA-5263630)	0.701	4
P63104	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.701	5
P46109	1	CRKL [cytosol] (R-HSA-354384)	0.692	4
P12830	3	CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929)	0.678	3
P04792	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.669	3
P35221	1	CTNNA1 [plasma membrane] (R-HSA-191735)	0.669	4
P07900	1	HSP90AA1 [cytosol] (R-HSA-192864)	0.667	5
O60716	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.659	4
P38646	2	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)	0.659	4
Q13322	1	GRB10 [cytosol] (R-HSA-110009)	0.646	3
Q9UNE7	1	STUB1 [cytosol] (R-HSA-975970)	0.635	3
P46940	1	IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
Q96B97	1	SH3KBP1 [cytosol] (R-HSA-182957)	0.623	3
O14965	2	AURKA [cytosol] (R-HSA-174254) AURKA [nucleoplasm] (R-HSA-4655443)	0.602	4
P07992	1	ERCC1 [nucleoplasm] (R-HSA-54427)	0.599	21
P00519	4	ABL1 [cytosol] (R-HSA-375987) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251)	0.592	2
P01135	1	TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476)	0.592	2
P43403	1	ZAP70 [cytosol] (R-HSA-202397)	0.592	2
P46108	1	CRK [cytosol] (R-HSA-2980677)	0.592	3
P51451	1	BLK [cytosol] (R-HSA-983580)	0.592	2
P14174	1	MIF [secretory granule lumen] (R-HSA-6803282)	0.591	3
Q68CZ2	1	TNS3 [cytosol] (R-HSA-8875524)	0.581	4
P17936	13	IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(28-186) [extracellular region] (R-HSA-381454) IGFBP3(291-187) [extracellular region] (R-HSA-381410)	0.576	3
P08631	1	HCK [cytosol] (R-HSA-167708)	0.573	2
P41240	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.573	2
Q8WUM4	1	PDCD6IP [cytosol] (R-HSA-917717)	0.573	3
Q99962	3	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495)	0.573	3
P97313	3	K48polyUb-PRKDC [cytosol] (R-MMU-8938766) PRKDC [cytosol] (R-MMU-3134816) PRKDC [nucleoplasm] (R-MMU-62161)	0.556	4
P23528	2	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813)	0.553	2
P06493	5	CDK1 [cytosol] (R-HSA-170075) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [nucleoplasm] (R-HSA-68889) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.547	2
P29350	1	PTPN6 [cytosol] (R-HSA-197938)	0.547	2
Q05397	4	PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) pY-PTK2 [cytosol] (R-HSA-9632393)	0.547	3
Q13480	1	GAB1 [cytosol] (R-HSA-179795)	0.547	3
Q96CW1	1	AP2M1 [plasma membrane] (R-HSA-167585)	0.547	4
Q9UQB8	1	BAIAP2 [cytosol] (R-HSA-442574)	0.547	2
P11021	2	HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322)	0.527	5
P31943	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	2
Q9H0D6	1	XRN2 [nucleoplasm] (R-HSA-6791205)	0.527	5
Q9UQC2	1	GAB2 [cytosol] (R-HSA-508239)	0.527	2
P13866	1	SLC5A1 [plasma membrane] (R-HSA-189243)	0.524	3
P30530	1	AXL [plasma membrane] (R-HSA-197705)	0.524	4
Q14956	1	GPNMB [plasma membrane] (R-HSA-8857550)	0.524	3
Q15109	1	AGER [plasma membrane] (R-HSA-197639)	0.524	2
O43561	3	LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.508	2
O75791	1	GRAP2 [cytosol] (R-HSA-202367)	0.508	2
P09769	1	FGR [cytosol] (R-HSA-432116)	0.508	2
P17252	3	p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [cytosol] (R-HSA-58196) PRKCA [nucleoplasm] (R-HSA-450530)	0.508	2
P18433	1	PTPRA [plasma membrane] (R-HSA-388755)	0.508	2
P31948	1	STIP1 [cytosol] (R-HSA-443857)	0.508	2
P35813	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.508	2
Q12933	1	TRAF2 [cytosol] (R-HSA-66370)	0.508	3
Q13094	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.508	2
Q14247	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.508	3
Q9Y2R2	1	PTPN22 [cytosol] (R-HSA-8852205)	0.508	2
P22682	3	CBL [cytosol] (R-MMU-112199) phospho-p-Y700,Y731,Y774-CBL [cytosol] (R-MMU-912656) phospho-PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-MMU-8848826)	0.499	2
Q96A65	1	EXOC4 [plasma membrane] (R-HSA-264989)	0.499	2
P07355	2	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [extracellular region] (R-HSA-6806242)	0.463	3
P25098	3	ADRBK1 [cilium] (R-HSA-5632504) GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969)	0.463	3
P46934	1	NEDD4 [cytosol] (R-HSA-975992)	0.463	3
Q9UPT5	1	EXOC7 [plasma membrane] (R-HSA-2872288)	0.463	2