Reactome | UniProt:P00533 EGFR

UniProt:P00533 EGFR

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

EGFR_HUMAN, O00688, O00732, P06268, Q14225, Q68GS5, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5

List of interactors in Reactome

Interactors (148)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P00533	2	EGFR [plasma membrane] (R-HSA-179837) EGFRvIII [plasma membrane] (R-HSA-1214162)	0.981	29
P62993	1	GRB2 [cytosol] (R-HSA-8983328)	0.981	56
P01133	2	EGF [extracellular region] (R-HSA-179863) Pro-EGF [plasma membrane] (R-HSA-179888)	0.973	29
P29353	2	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680)	0.973	41
P22681	3	CBL [cytosol] (R-HSA-112199) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826)	0.964	26
P04626	1	ERBB2 [plasma membrane] (R-HSA-372889)	0.954	25
P40763	6	p-S727-STAT3 [cytosol] (R-HSA-198705) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044)	0.919	15
P12931	5	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y416-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701)	0.9	9
P08238	1	HSP90AB1 [cytosol] (R-HSA-419617)	0.89	10
P18031	1	PTPN1 [cytosol] (R-HSA-210625)	0.864	8
P19174	4	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682)	0.85	6
P31947	1	SFN [cytosol] (R-HSA-1445105)	0.833	9
P07948	4	LYN [cytosol] (R-HSA-354251) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y396-LYN [plasma membrane] (R-HSA-2454229)	0.82	7
Q03135	3	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [plasma membrane] (R-HSA-534994)	0.813	7
Q9UBN7	2	HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [nucleoplasm] (R-HSA-351589)	0.809	12
Q05209	1	PTPN12 [cytosol] (R-HSA-432933)	0.807	5
P11142	5	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.803	7
P20417	1	Ptpn1 [cytosol] (R-RNO-210625)	0.802	11
P08581	1	MET [plasma membrane] (R-HSA-419603)	0.8	8
P16885	6	p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [cytosol] (R-HSA-1604645) PLCG2 [plasma membrane] (R-HSA-114601)	0.793	6
P10599	4	2xHC-TXN [cytosol] (R-HSA-73668) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [cytosol] (R-HSA-66000) TXN [nucleoplasm] (R-HSA-9617732)	0.785	5
P01135	1	TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476)	0.779	4
P07900	1	HSP90AA1 [cytosol] (R-HSA-192864)	0.778	7
P42224	4	p-STAT1 [cytosol] (R-HSA-8950418) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.774	7
P16333	1	NCK1 [cytosol] (R-HSA-197954)	0.773	5
P04083	1	ANXA1 [cytosol] (R-HSA-5263630)	0.772	5
P63104	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.772	6
Q06124	2	PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745)	0.772	7
P27986	1	PIK3R1 [cytosol] (R-HSA-74789)	0.762	6
P46109	1	CRKL [cytosol] (R-HSA-354384)	0.749	5
O60716	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.745	5
P38646	2	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)	0.745	5
Q05397	4	PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) pY-PTK2 [cytosol] (R-HSA-9632393)	0.745	7
Q96JA1	1	LRIG1 [plasma membrane] (R-HSA-197745)	0.743	6
P12830	3	CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929)	0.735	4
Q13322	1	GRB10 [cytosol] (R-HSA-110009)	0.729	4
Q9UNE7	1	STUB1 [cytosol] (R-HSA-975970)	0.721	4
P00519	4	ABL1 [cytosol] (R-HSA-375987) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251)	0.692	3
P42684	1	ABL2 [cytosol] (R-HSA-375998)	0.692	9
P43403	1	ZAP70 [cytosol] (R-HSA-202397)	0.692	3
P46108	1	CRK [cytosol] (R-HSA-2980677)	0.692	4
P51451	1	BLK [cytosol] (R-HSA-983580)	0.692	3
Q13239	1	SLA [cytosol] (R-HSA-9706158)	0.692	3
P16234	2	PDGFRA [plasma membrane] (R-HSA-186794) PDGFRA D842V [plasma membrane] (R-HSA-9671549)	0.683	4
Q68CZ2	1	TNS3 [cytosol] (R-HSA-8875524)	0.683	5
O60603	1	TLR2 [plasma membrane] (R-HSA-9637646)	0.681	3
P41240	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.681	3
Q8WUM4	1	PDCD6IP [cytosol] (R-HSA-917717)	0.681	4
Q99962	3	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495)	0.681	4
Q9UQC2	1	GAB2 [cytosol] (R-HSA-508239)	0.669	3
P23528	2	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813)	0.668	3
P06493	5	CDK1 [cytosol] (R-HSA-170075) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [nucleoplasm] (R-HSA-68889) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.667	3
Q13480	1	GAB1 [cytosol] (R-HSA-179795)	0.667	4
Q96CW1	1	AP2M1 [plasma membrane] (R-HSA-167585)	0.667	5
Q9UQB8	1	BAIAP2 [cytosol] (R-HSA-442574)	0.667	3
P08631	1	HCK [cytosol] (R-HSA-167708)	0.653	3
O43561	3	LAT [plasma membrane] (R-HSA-202322) p-5Y-LAT [plasma membrane] (R-HSA-202364) p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)	0.635	3
O75791	1	GRAP2 [cytosol] (R-HSA-202367)	0.635	3
P09769	1	FGR [cytosol] (R-HSA-432116)	0.635	3
P17252	3	p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [cytosol] (R-HSA-58196) PRKCA [nucleoplasm] (R-HSA-450530)	0.635	3
P18433	1	PTPRA [plasma membrane] (R-HSA-388755)	0.635	3
P31948	1	STIP1 [cytosol] (R-HSA-443857)	0.635	3
P42229	1	STAT5A [nucleoplasm] (R-HSA-9701901)	0.635	4
Q12933	1	TRAF2 [cytosol] (R-HSA-66370)	0.635	4
Q13094	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.635	3
Q14247	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.635	4
Q9Y2R2	1	PTPN22 [cytosol] (R-HSA-8852205)	0.635	3
P46940	1	IQGAP1 [plasma membrane] (R-HSA-381681)	0.626	4
Q96B97	1	SH3KBP1 [cytosol] (R-HSA-182957)	0.623	3
P04792	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.615	3
P35221	1	CTNNA1 [plasma membrane] (R-HSA-191735)	0.615	4
Q99075	7	HB-EGF(161-208) [plasma membrane] (R-HSA-9624270) HBEGF(149-208) [extracellular region] (R-HSA-2179391) HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776) HBEGF(20-208) [plasma membrane] (R-HSA-5334771) HBEGF(20-208) [plasma membrane] (R-HSA-2179406) HBEGF(20-62) [extracellular region] (R-HSA-2179390) HBEGF(63-148) [extracellular region] (R-HSA-1233234)	0.609	3
P08575	1	PTPRC [plasma membrane] (R-HSA-197931)	0.592	2
P14174	1	MIF [secretory granule lumen] (R-HSA-6803282)	0.591	3
O14965	2	AURKA [cytosol] (R-HSA-174254) AURKA [nucleoplasm] (R-HSA-4655443)	0.581	4
P07992	1	ERCC1 [nucleoplasm] (R-HSA-54427)	0.571	21
P62994	1	Grb2 [cytosol] (R-RNO-74686)	0.564	5
Q07889	1	SOS1 [cytosol] (R-HSA-64847)	0.564	2
O00170	1	AIP [cytosol] (R-HSA-8936839)	0.553	2
O00401	1	N-WASP [cytosol] (R-HSA-201873)	0.553	2
O14543	1	SOCS3 [cytosol] (R-HSA-873794)	0.553	2
O14544	1	SOCS6 [cytosol] (R-HSA-1469969)	0.553	2
O43639	1	NCK2 [cytosol] (R-HSA-204885)	0.553	2
P04049	3	hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) RAF1 [cytosol] (R-HSA-167205)	0.553	2
P05067	12	APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-713) [extracellular region] (R-HSA-879340) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325)	0.553	2
P06396	3	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272)	0.553	2
P07949	1	RET [plasma membrane] (R-HSA-8853797)	0.553	2
P10636	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.553	2
P11309	1	PIM1 [nucleoplasm] (R-HSA-3215094)	0.553	2
P14625	1	HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.553	2
P15311	1	EZR [cytosol] (R-HSA-9020826)	0.553	2
P15498	2	p-Y174-VAV1 [cytosol] (R-HSA-437946) VAV1 [cytosol] (R-HSA-195066)	0.553	2
P16152	1	CBR1 [cytosol] (R-HSA-2142784)	0.553	2
P20336	1	RAB3A [plasma membrane] (R-HSA-210461)	0.553	2
P21291	1	CSRP1 [nucleoplasm] (R-HSA-5660398)	0.553	2
P26641	1	EEF1G [cytosol] (R-HSA-156925)	0.553	2
P30307	8	CDC25C [cytosol] (R-HSA-157879) CDC25C [nucleoplasm] (R-HSA-69741) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654)	0.553	2
P31749	7	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.553	2
P31946	1	YWHAB [cytosol] (R-HSA-48888)	0.553	2
P32121	1	ARRB2 [cytosol] (R-HSA-416464)	0.553	2
P37840	2	SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.553	2
P41222	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.553	2
P42685	1	p-Y387-FRK [cytosol] (R-HSA-8847965)	0.553	2
P45983	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.553	2
P49407	1	ARRB1 [cytosol] (R-HSA-264470)	0.553	2
P52306	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.553	2
P52630	1	STAT2 [cytosol] (R-HSA-882029)	0.553	2
P53041	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.553	2
P60880	5	SNAP25 [plasma membrane] (R-HSA-2029017) SNAP25(1-197) [plasma membrane] (R-HSA-3004546) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(199-206) [cytosol] (R-HSA-5244501)	0.553	2
Q02246	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.553	2
Q02790	2	FKBP4 [cytosol] (R-HSA-5618108) FKBP4 [nucleoplasm] (R-HSA-5324621)	0.553	2
Q05513	1	PRKCZ [cytosol] (R-HSA-58218)	0.553	2
Q06830	2	p-T90-PRDX1 [cytosol] (R-HSA-8868564) PRDX1 [cytosol] (R-HSA-3341270)	0.553	2
Q07954	1	LRP1 [plasma membrane] (R-HSA-1454844)	0.553	2
Q08881	1	ITK [cytosol] (R-HSA-202319)	0.553	2
Q13153	3	Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629)	0.553	2
Q13905	2	RAPGEF1 [cytosol] (R-HSA-3008672) RAPGEF1 [cytosol] (R-HSA-913472)	0.553	2
Q14155	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.553	2
Q16186	1	ADRM1 [cytosol] (R-HSA-5665939)	0.553	2
Q16620	2	NTRK2 [plasma membrane] (R-HSA-6798236) p-Y706,Y707-NTRK2 [plasma membrane] (R-HSA-9037044)	0.553	2
Q92733	1	PRCC [nucleoplasm] (R-HSA-8867896)	0.553	2
Q99704	2	DOK1 [cytosol] (R-HSA-74763) p-Y362-DOK1 [cytosol] (R-HSA-8848784)	0.553	2
Q99952	1	PTPN18 [cytosol] (R-HSA-8864101)	0.553	2
Q99963	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.553	2
Q9H6Q3	1	SLA2 [cytosol] (R-HSA-9706161)	0.553	2
Q9UGK3	1	STAP2 [cytosol] (R-HSA-8848028)	0.553	2
Q9Y6K9	2	IKBKG [cytosol] (R-HSA-168108) IKBKG [nucleoplasm] (R-HSA-4755413)	0.553	2
P23468	1	PTPRD [plasma membrane] (R-HSA-6797868)	0.547	2
P29350	1	PTPN6 [cytosol] (R-HSA-197938)	0.547	2
P17936	13	IGFBP3 [extracellular region] (R-HSA-381512) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(28-186) [extracellular region] (R-HSA-381454) IGFBP3(291-187) [extracellular region] (R-HSA-381410)	0.539	3
P0DTC2	6	14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9696917) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796)	0.537	4
P11021	2	HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322)	0.527	5
P31943	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	2
Q9H0D6	1	XRN2 [nucleoplasm] (R-HSA-6791205)	0.527	5
P13866	1	SLC5A1 [plasma membrane] (R-HSA-189243)	0.524	3
Q14956	1	GPNMB [plasma membrane] (R-HSA-8857550)	0.524	3
Q15109	1	AGER [plasma membrane] (R-HSA-197639)	0.524	2
P97313	3	Prkdc [cytosol] (R-MMU-8938766) Prkdc [cytosol] (R-MMU-3134816) Prkdc [nucleoplasm] (R-MMU-62161)	0.518	4
P35813	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.508	2
P22682	3	Cbl [cytosol] (R-MMU-112199) phospho-Cbl [cytosol] (R-MMU-8848826) phospho-Cbl [cytosol] (R-MMU-912656)	0.499	2
Q96A65	1	EXOC4 [plasma membrane] (R-HSA-264989)	0.499	2
Q9QZC5	1	Grb7 [cytosol] (R-RNO-204819)	0.499	7
P30530	1	AXL [plasma membrane] (R-HSA-197705)	0.471	4
O43752	1	STX6 [trans-Golgi network membrane] (R-HSA-6811007)	0.463	3
P07355	2	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [extracellular region] (R-HSA-6806242)	0.463	3
P25098	3	ADRBK1 [cilium] (R-HSA-5632504) GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969)	0.463	3
P46934	1	NEDD4 [cytosol] (R-HSA-975992)	0.463	3
Q9UPT5	1	EXOC7 [plasma membrane] (R-HSA-2872288)	0.463	2

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