Reactome | UniProt:P05067 APP

UniProt:P05067 APP

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

A4_HUMAN, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58

List of interactors in Reactome

Interactors (139)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
P05067	12	APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-713) [extracellular region] (R-HSA-879340) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325)	0.993	107
O00213	1	APBB1 [nucleoplasm] (R-HSA-5683987)	0.912	10
P56817	8	7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326) BACE1 [endosome membrane] (R-HSA-5692942) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) BACE1(46-501) [plasma membrane] (R-HSA-5692933)	0.865	11
P04156	1	PRNP [plasma membrane] (R-HSA-375060)	0.775	6
P10636	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.749	8
P02647	3	APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [extracellular region] (R-HSA-174720) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640)	0.747	8
P27797	4	CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.737	5
Q02410	1	APBA1 [cytosol] (R-HSA-5336459)	0.729	5
P30101	1	PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.703	6
Q92673	1	SORL1 [endosome membrane] (R-HSA-8871475)	0.69	5
P05412	4	JUN [cytosol] (R-HSA-168194) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [cytosol] (R-HSA-8868682) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237)	0.675	5
P07437	1	TUBB [cytosol] (R-HSA-9020816)	0.666	5
P07900	1	HSP90AA1 [cytosol] (R-HSA-192864)	0.666	5
P11021	2	HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322)	0.666	6
P11142	5	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.666	8
P60709	2	ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990)	0.666	8
P61764	1	STXBP1 [plasma membrane] (R-HSA-2980862)	0.666	7
P62937	3	PPIA [cytosol] (R-HSA-173123) PPIA [extracellular exosome] (R-HSA-6801538) PPIA [extracellular region] (R-HSA-173646)	0.666	4
O14672	1	ADAM10 [plasma membrane] (R-HSA-157237)	0.659	7
P37840	3	p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.659	6
Q13526	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.646	4
P01137	1	TGFB1 [extracellular region] (R-HSA-170838)	0.604	3
P10636	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.59	4
P29353	2	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680)	0.589	6
P08138	7	NGFR [plasma membrane] (R-HSA-193664) NGFR(251-272) [plasma membrane] (R-HSA-194509) NGFR(251-427) [endosome] (R-HSA-209541) NGFR(251-427) [plasma membrane] (R-HSA-194476) NGFR(273-427) [cytosol] (R-HSA-194458) NGFR(273-427) [nucleoplasm] (R-HSA-197473) NGFR(29-250) [extracellular region] (R-HSA-194470)	0.558	2
O14494	1	PLPP1 [plasma membrane] (R-HSA-76106)	0.556	3
O15392	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.556	3
O43752	1	STX6 [trans-Golgi network membrane] (R-HSA-6811007)	0.556	3
O76024	1	WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
P00734	7	10xCbxE-F2(25-622) [endoplasmic reticulum lumen] (R-HSA-159800) 10xCbxE-F2(25-622) [Golgi lumen] (R-HSA-159841) 10xCbxE-F2(44-327) [extracellular region] (R-HSA-140786) 10xCbxE-F2(44-622) [extracellular region] (R-HSA-140674) 10xCbxE-F2(44-622) [Golgi lumen] (R-HSA-159845) F2(25-622) [endoplasmic reticulum lumen] (R-HSA-159739) prothrombin (factor II) propeptide [Golgi lumen] (R-HSA-159759)	0.556	3
P00748	1	factor XII [plasma membrane] (R-HSA-158214)	0.556	3
P00749	1	PLAU(21-431) [extracellular region] (R-HSA-158979)	0.556	3
P01116	4	pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane] (R-HSA-9653578) pS181-S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9653482) S-Farn-Me KRAS4B [endoplasmic reticulum membrane] (R-HSA-9649690) S-Farn-Me KRAS4B [plasma membrane] (R-HSA-9647815)	0.556	3
P01138	2	NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047)	0.556	9
P01375	3	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(77-233) [extracellular region] (R-HSA-976821)	0.556	3
P02743	1	APCS(20-223) [extracellular region] (R-HSA-976737)	0.556	3
P04049	3	hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) RAF1 [cytosol] (R-HSA-167205)	0.556	3
P04183	1	TK1 [cytosol] (R-HSA-73500)	0.556	3
P04271	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
P04792	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
P05556	1	ITGB1 [plasma membrane] (R-HSA-57596)	0.556	3
P06241	3	FYN [cytosol] (R-HSA-200917) p-Y420-FYN [cytosol] (R-HSA-391821) p-Y531-FYN [cytosol] (R-HSA-391819)	0.556	3
P06493	6	CDK1 [cytosol] (R-HSA-170075) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) CDK1 [nucleoplasm] (R-HSA-68889) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-Y4-CDK1 [cytosol] (R-HSA-9836187)	0.556	3
P07602	5	PSAP [lysosomal lumen] (R-HSA-9840325) PSAP(195-273) [lysosomal lumen] (R-HSA-9840336) PSAP(311-391) [lysosomal membrane] (R-HSA-1605602) PSAP(405-486) [lysosomal lumen] (R-HSA-9840328) PSAP(60-142) [lysosomal lumen] (R-HSA-351333)	0.556	3
P07948	4	LYN [cytosol] (R-HSA-354251) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229)	0.556	3
P08253	5	MMP2(110-660) [extracellular region] (R-HSA-381456) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(67-109) [extracellular region] (R-HSA-1604371) MMP2(67-660) [extracellular region] (R-HSA-1604345)	0.556	3
P09429	2	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221)	0.556	3
P09958	3	FURIN [Golgi membrane] (R-HSA-157049) FURIN [macropinosome membrane] (R-HSA-9837714) FURIN [plasma membrane] (R-HSA-2159856)	0.556	3
P0CG47	4	UBB [cytosol] (R-HSA-8853516) UBB(1-76) [cytosol] (R-HSA-939214) UBB(153-228) [cytosol] (R-HSA-939230) UBB(77-152) [cytosol] (R-HSA-939213)	0.556	3
P10415	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.556	3
P10809	1	HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	6
P11940	1	PABPC1 [cytosol] (R-HSA-156803)	0.556	3
P14625	1	HSP90B1 [endoplasmic reticulum lumen] (R-HSA-981545)	0.556	3
P16671	1	4xPalmC-CD36 [plasma membrane] (R-HSA-51645)	0.556	3
P17612	2	PRKACA [cytosol] (R-HSA-57844) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
P17980	1	PSMC3 [cytosol] (R-HSA-68774)	0.556	6
P18509	1	ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679)	0.556	3
P18827	1	SDC1 [plasma membrane] (R-HSA-174758)	0.556	3
P19404	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
P19419	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.556	3
P20226	1	TBP [nucleoplasm] (R-HSA-83718)	0.556	3
P21673	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
P25090	1	FPR2 [plasma membrane] (R-HSA-416408)	0.556	3
P25098	3	ADRBK1 [cilium] (R-HSA-5632504) GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969)	0.556	3
P26441	1	CNTF [extracellular region] (R-HSA-5696441)	0.556	3
P28482	3	MAPK1 [cytosol] (R-HSA-59282) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853)	0.556	3
P31146	1	CORO1A [cytosol] (R-HSA-9636432)	0.556	3
P31946	1	YWHAB [cytosol] (R-HSA-48888)	0.556	3
P36507	4	MAP2K2 [cytosol] (R-HSA-59504) MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) p-S,T-MAP2K2 [cytosol] (R-HSA-109848)	0.556	3
P42858	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
P43354	2	NR4A2 [nucleoplasm] (R-HSA-376305) polySUMO2,3-K558,K577-NR4A2 [nucleoplasm] (R-HSA-4755517)	0.556	3
P43405	2	p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.556	3
P48730	2	CSNK1D [cytosol] (R-HSA-380315) CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5685717)	0.556	3
P51572	5	BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.556	3
P53350	4	p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603) PLK1 [nucleoplasm] (R-HSA-156720)	0.556	3
P53778	2	MAPK12 [cytosol] (R-HSA-171025) p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021)	0.556	3
P56211	2	ARPP19 [nucleoplasm] (R-HSA-2160959) p-S62-ARPP19 [nucleoplasm] (R-HSA-2168081)	0.556	3
P61586	1	RHOA [plasma membrane] (R-HSA-194510)	0.556	3
P62136	1	PPP1CA [cytosol] (R-HSA-163525)	0.556	3
P62942	1	FKBP1A [cytosol] (R-HSA-2026007)	0.556	3
P63000	1	RAC1 [cytosol] (R-HSA-442615)	0.556	3
P63151	1	PPP2R2A [cytosol] (R-HSA-377253)	0.556	3
P67775	1	PPP2CA [cytosol] (R-HSA-165971)	0.556	3
P83916	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.556	6
P84022	2	p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855)	0.556	3
P98082	2	DAB2 [cytosol] (R-HSA-8862456) DAB2 [plasma membrane] (R-HSA-2980808)	0.556	3
P99999	6	AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308) apo-CYCS [mitochondrial inner membrane] (R-HSA-352608) CYCS [cytosol] (R-HSA-53259) CYCS [mitochondrial intermembrane space] (R-HSA-114244) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-HSA-352607) Cytochrome c (reduced) [mitochondrial inner membrane] (R-HSA-352609)	0.556	3
Q00403	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.556	3
Q00535	3	CDK5 [cytosol] (R-HSA-180064) CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.556	3
Q01094	1	E2F1 [nucleoplasm] (R-HSA-68639)	0.556	3
Q01658	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
Q02246	1	CNTN2 [plasma membrane] (R-HSA-373618)	0.556	3
Q03135	3	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [plasma membrane] (R-HSA-534994)	0.556	3
Q05586	1	GRIN1 [endoplasmic reticulum membrane] (R-HSA-9609763)	0.556	3
Q05655	5	p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [cytosol] (R-HSA-212551)	0.556	3
Q13485	4	SMAD4 [cytosol] (R-HSA-170862) SMAD4 [nucleoplasm] (R-HSA-177103) Ub-SMAD4 [cytosol] (R-HSA-9773859) Ub-SMAD4 [nucleoplasm] (R-HSA-9773863)	0.556	3
Q13501	2	K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1 [cytosol] (R-HSA-193937)	0.556	6
Q14289	1	PTK2B [cytosol] (R-HSA-390932)	0.556	3
Q14790	4	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158)	0.556	3
Q15084	1	PDIA6 [endoplasmic reticulum membrane] (R-HSA-535530)	0.556	3
Q15109	1	AGER [plasma membrane] (R-HSA-197639)	0.556	3
Q16143	1	SNCB [cytosol] (R-HSA-5660390)	0.556	3
Q16512	1	p-T774-PKN1 [cytosol] (R-HSA-5623651)	0.556	3
Q6ZW49	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.556	3
Q7Z2H8	1	SLC36A1 [plasma membrane] (R-HSA-375419)	0.556	3
Q8N2W9	2	monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415) PIAS4 [nucleoplasm] (R-HSA-2993789)	0.556	3
Q8TBC4	1	UBA3 [cytosol] (R-HSA-947632)	0.556	3
Q92934	4	BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297) p-S99-BAD [cytosol] (R-HSA-198335)	0.556	3
Q92993	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
Q96FE5	1	LINGO1 [plasma membrane] (R-HSA-3006563)	0.556	3
Q96L34	1	MARK4 [cytosol] (R-HSA-5626653)	0.556	3
Q96S59	1	RANBP9 [cytosol] (R-HSA-374586)	0.556	3
Q99466	8	NEXT4 [plasma membrane] (R-HSA-157641) NICD4 [cytosol] (R-HSA-157636) NICD4 [nucleoplasm] (R-HSA-157945) NOTCH4(1432-1466) [plasma membrane] (R-HSA-157635) p-4S-NICD4 [cytosol] (R-HSA-9604329) p-NICD4 [nucleoplasm] (R-HSA-9604611) PolyUb-p-NICD4 [nucleoplasm] (R-HSA-9604624) Pre-NOTCH4 [endoplasmic reticulum membrane] (R-HSA-157121)	0.556	3
Q99497	2	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141)	0.556	3
Q99547	1	MPHOSPH6 [nucleoplasm] (R-HSA-6791553)	0.556	3
Q9BXM7	4	PINK1 [cytosol] (R-HSA-5205637) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.556	3
Q9BYZ2	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
Q9GZQ8	2	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B [cytosol] (R-HSA-5205651)	0.556	3
Q9NY61	1	AATF [cytosol] (R-HSA-205071)	0.556	3
Q9Y5B9	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.556	3
O60315	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.553	2
O60673	1	REV3L [nucleoplasm] (R-HSA-110278)	0.553	2
O95243	1	MBD4 [nucleoplasm] (R-HSA-3006633)	0.553	2
P00533	2	EGFR [plasma membrane] (R-HSA-179837) EGFRvIII [plasma membrane] (R-HSA-1214162)	0.553	2
P26367	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.553	2
Q2M1K9	1	ZNF423 [nucleoplasm] (R-HSA-3222318)	0.553	2
Q5SW96	1	LDLRAP1 [plasma membrane] (R-HSA-171143)	0.553	2
Q92664	1	GTF3A [nucleoplasm] (R-HSA-65892)	0.553	2
Q9H0D6	1	XRN2 [nucleoplasm] (R-HSA-6791205)	0.553	2
P46933	1	Apbb1 [nucleoplasm] (R-RNO-5683987)	0.528	2
P01100	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.524	3
P21359	1	NF1(2-2839) [cytosol] (R-HSA-947770)	0.508	3
P78352	1	DLG4 [plasma membrane] (R-HSA-202135)	0.499	2
P07196	1	NEFL [cytosol] (R-HSA-432284)	0.483	2
Q99683	1	MAP3K5 [cytosol] (R-HSA-167709)	0.483	2
O14879	1	IFIT3 [cytosol] (R-HSA-947491)	0.482	2
P04578	1	Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343)	0.462	2
Q15392	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.462	3
Q99720	1	SIGMAR1 [cytosol] (R-HSA-9679757)	0.462	3

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