Douglas R McDonald

 ORCID
https://orcid.org/0000-0001-5435-8145
Reviewed Pathways (12/12)
Date Identifier Pathway Reference
2014-09-06 R-HSA-5602358 Diseases associated with the TLR signaling cascade BibTex
2014-09-06 R-HSA-5602410 TLR3 deficiency - HSE BibTex
2014-09-06 R-HSA-5602571 TRAF3 deficiency - HSE BibTex
2014-09-06 R-HSA-5602680 MyD88 deficiency (TLR5) BibTex
2014-09-06 R-HSA-5602415 UNC93B1 deficiency - HSE BibTex
2014-09-06 R-HSA-5602636 IKBKB deficiency causes SCID BibTex
2014-09-06 R-HSA-5603037 IRAK4 deficiency (TLR5) BibTex
2014-09-06 R-HSA-5602498 MyD88 deficiency (TLR2/4) BibTex
2014-09-06 R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) BibTex
2014-09-06 R-HSA-5603041 IRAK4 deficiency (TLR2/4) BibTex
2014-09-06 R-HSA-5602566 TICAM1 deficiency - HSE BibTex
2014-09-06 R-HSA-5603029 IkBA variant leads to EDA-ID BibTex
Reviewed Reactions (15/15)
Date Identifier Reaction Reference
2014-09-06 R-HSA-5602549 Defective TLR3 does not bind viral dsRNA BibTex
2014-09-06 R-HSA-5602624 Defective TRAF3 does not transmit the signal BibTex
2014-09-06 R-HSA-5602316 Defective MyD88 does not oligomerize within the complex of activated TLR5 BibTex
2014-09-06 R-HSA-5607838 Defective UNC93B1 does not bind TLR3 BibTex
2014-09-06 R-HSA-5228840 Defective IKBKB (IKK2) does not form a complex with IKBKA and IKBKG BibTex
2014-09-06 R-HSA-5602603 IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway BibTex
2014-09-06 R-HSA-5602472 Defective IRAK4 does not form a complex with MyD88 within the TLR5 complex BibTex
2014-09-06 R-HSA-5602606 Defective MyD88 does not bind MAL(TIRAP):TLR2/4 BibTex
2014-09-06 R-HSA-5602383 Defective MyD88 does not oligomerize within the activated TLR2/4 complex BibTex
2014-09-06 R-HSA-5262921 Defective IKBKG (NEMO) destabilizes the association of IKBKA:IKBKB:IKBKG (via TLR) BibTex
2014-09-06 R-HSA-5602672 Defective IRAK4 does not bind MyD88 within the TLR2/4 complex BibTex
2014-09-06 R-HSA-5602353 IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in TLR2/4 pathway BibTex
2014-09-06 R-HSA-5602712 TICAM1 deficiency blocks TLR3 pathway BibTex
2014-09-06 R-HSA-5228811 NFKBIA variant is not phosphorylated within IkBA:NF-kappaB BibTex
2014-09-06 R-HSA-5609665 IKBKA, IKBKB and IKBKG form IKK complex BibTex