Karen Rothfels

Ontario Institute for Cancer Research
Authored Pathways (15/130)
Date Identifier Pathway Reference
2018-12-15 R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BibTex
2018-12-15 R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ BibTex
2017-09-29 R-HSA-8939211 ESR-mediated signaling BibTex
2017-09-29 R-HSA-9018519 Estrogen-dependent gene expression BibTex
2017-09-29 R-HSA-9009391 Non-genomic estrogen signaling BibTex
2017-05-24 R-HSA-9006934 Signaling by Receptor Tyrosine Kinases BibTex
2017-05-24 R-HSA-9006931 Signaling by Nuclear Receptors BibTex
2017-05-24 R-HSA-9006936 Signaling by TGF-beta family members BibTex
2017-05-24 R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases BibTex
2017-05-24 R-HSA-9006925 Intracellular signaling by second messengers BibTex
2017-05-24 R-HSA-9006921 Integrin signaling BibTex
2017-02-07 R-HSA-8951664 Neddylation BibTex
2016-06-29 R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs BibTex
2016-06-29 R-HSA-9007101 Rab regulation of trafficking BibTex
2016-06-03 R-HSA-8873719 RAB geranylgeranylation BibTex
Authored Reactions (15/891)
Date Identifier Reaction Reference
2018-12-15 R-HSA-9624527 AKT-phosphorylated FOXO3 translocates to cytosol BibTex
2018-12-15 R-HSA-9623999 BCL gene expression downstream of ESR1 BibTex
2018-12-15 R-HSA-9624526 AKT phosphorylates FOXO3 downstream of ESR1 and EGFR BibTex
2018-12-15 R-HSA-9632873 p-S10 CDKN1B translocates to the cytosol BibTex
2018-12-15 R-HSA-9625465 E2-mediated FOS gene expression BibTex
2018-12-15 R-HSA-9632868 CDKN1B is phosphorylated in response to estrogen BibTex
2018-12-15 R-HSA-9625479 SRF and ELK1 bind the FOS gene BibTex
2018-12-15 R-HSA-9625487 PTK2 autophosphorylates downstream of EGFR BibTex
2018-12-15 R-HSA-9625482 PTK2 binds activated EGFR BibTex
2018-12-15 R-HSA-9632412 PTK2 is recruited to methylated ESR1 BibTex
2018-12-15 R-HSA-9625813 S1P binds S1PR3 in response to E2 stimulation BibTex
2018-12-15 R-HSA-9634584 Estrogen receptor binds IGF1R and SHC1 in response to estrogen BibTex
2018-12-15 R-HSA-9624272 MMPs cleave HB-EGF BibTex
2018-12-15 R-HSA-9632182 PRMT1 methylates ESRs BibTex
2018-12-15 R-HSA-9633044 ESR binds STRN BibTex
Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) BibTex
Reviewed Reactions (12/12)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-5618099 SH binds SHR within the HSP90 chaperone complex BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex