Karen Rothfels

 ORCID
https://orcid.org/0000-0002-0705-7048
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Authored Pathways (15/242)
Date Identifier Pathway Reference
2024-07-29 R-HSA-9865118 Diseases of branched-chain amino acid catabolism BibTex
2024-07-29 R-HSA-9915355 Beta-ketothiolase deficiency BibTex
2024-07-29 R-HSA-9865114 Maple Syrup Urine Disease BibTex
2024-07-29 R-HSA-9865113 Loss-of-function mutations in DBT cause MSUD2 BibTex
2024-07-29 R-HSA-9912529 H139Hfs13* PPM1K causes a mild variant of MSUD BibTex
2024-07-29 R-HSA-9907570 Loss-of-function mutations in DLD cause MSUD3/DLDD BibTex
2024-07-29 R-HSA-9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BibTex
2024-07-29 R-HSA-9909438 3-Methylcrotonyl-CoA carboxylase deficiency BibTex
2024-07-29 R-HSA-9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 BibTex
2024-07-29 R-HSA-9912481 Branched-chain ketoacid dehydrogenase kinase deficiency BibTex
2024-07-29 R-HSA-9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency BibTex
2024-07-29 R-HSA-9914274 3-methylglutaconic aciduria BibTex
2024-07-29 R-HSA-9914355 Isovaleric acidemia BibTex
2023-12-21 R-HSA-9856649 Transcriptional and post-translational regulation of MITF-M expression and activity BibTex
2023-12-21 R-HSA-9856651 MITF-M-dependent gene expression BibTex
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Authored Reactions (15/1,531)
Date Identifier Reaction Reference
2024-07-29 R-HSA-9915356 ACAT1 mutants don't synthesize propionyl-CoA or acetyl-CoA BibTex
2024-07-29 R-HSA-9865115 DBT loss-of-function mutants don't synthesize BCAA-CoA BibTex
2024-07-29 R-HSA-9912527 H139Hfs13* PPM1K does not dephosphorylate BCKDH BibTex
2024-07-29 R-HSA-9907572 Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT BibTex
2024-07-29 R-HSA-9909466 MCCC mutants don't synthesize beta-methylglutaconyl-CoA BibTex
2024-07-29 R-HSA-9916717 ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA BibTex
2024-07-29 R-HSA-9912480 BCKDK loss-of-function mutations do not phosphorylate BCKDH BibTex
2024-07-29 R-HSA-9916727 HIBCH mutants don't synthesize beta-hydroxyisobutyrate BibTex
2024-07-29 R-HSA-9914271 AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA BibTex
2024-07-29 R-HSA-9914837 IVD mutants don't synthesize beta-methylcrotonyl-CoA BibTex
2024-03-08 R-HSA-9865121 BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA BibTex
2024-03-01 R-HSA-9768533 SNAI2 binds CDH1 gene promoter BibTex
2024-03-01 R-HSA-9907144 MITF-M dimer and TFAP2A bind intronic elements in the IRF4 gene BibTex
2024-03-01 R-HSA-9907147 MITF-M-dependent IRF4 gene expression BibTex
2024-03-01 R-HSA-9907145 IRF4 binds the TYR promoter BibTex
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Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand BibTex
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Reviewed Reactions (15/15)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-9690534 NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9725885 P4 bind PGR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618099 NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
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