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What is Reactome ?
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Karen Rothfels
ORCID
https://orcid.org/0000-0002-0705-7048
Are you Karen Rothfels ? Register or Connect your ORCID
Project
Reactome
Affiliation
Ontario Institute for Cancer Research
Expand All
Authored Pathways (15/217)
Date
Identifier
Pathway
Reference
2023-10-14
R-HSA-9851151
MDK and PTN in ALK signaling
BibTex
2021-10-08
R-HSA-9755511
KEAP1-NFE2L2 pathway
BibTex
2021-10-08
R-HSA-9759194
Nuclear events mediated by NFE2L2
BibTex
2021-10-08
R-HSA-9762114
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
BibTex
2021-03-30
R-HSA-9725370
Signaling by ALK fusions and activated point mutants
BibTex
2021-03-30
R-HSA-9725371
Nuclear events stimulated by ALK signaling in cancer
BibTex
2021-03-30
R-HSA-9701898
STAT3 nuclear events downstream of ALK signaling
BibTex
2021-03-22
R-HSA-9700206
Signaling by ALK in cancer
BibTex
2021-03-22
R-HSA-9700649
Drug resistance of ALK mutants
BibTex
2021-03-22
R-HSA-9717323
ceritinib-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717326
crizotinib-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717329
lorlatinib-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717264
ASP-3026-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717319
brigatinib-resistant ALK mutants
BibTex
2021-03-22
R-HSA-9717301
NVP-TAE684-resistant ALK mutants
BibTex
Show all authored pathways...
Authored Reactions (15/1,387)
Date
Identifier
Reaction
Reference
2023-10-14
R-HSA-9851112
NPM1-ALK- and TYK2-dependent MCL1 gene expression
BibTex
2023-10-14
R-HSA-9851114
NPM1-ALK-dependent TYK2 phosphorylation
BibTex
2023-10-14
R-HSA-9851117
NPM1-ALK- and p-STAT3-dependent IRF4 gene expression
BibTex
2023-10-14
R-HSA-9851118
pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK
BibTex
2023-10-14
R-HSA-9851104
NPM1-ALK- and STAT3-dependent ICOS gene expression
BibTex
2023-10-14
R-HSA-9851106
p-Y705, S727 STAT3 dimer binds ICOS promoter
BibTex
2023-10-14
R-HSA-9851109
NPM1-ALK- and STAT3-dependent TWIST gene expression
BibTex
2023-10-14
R-HSA-9851131
NPM1-ALK-stimulated PRF1 gene expression
BibTex
2023-10-14
R-HSA-9851133
STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing
BibTex
2023-10-14
R-HSA-9851068
Crizotinib-driven IL10RA gene expression in NPM1-ALK
BibTex
2023-10-14
R-HSA-9851123
NPM1-ALK- and p-STAT3-dependent NOTCH gene expression
BibTex
2023-10-14
R-HSA-9851122
p-Y705,S727 STAT3 dimer binds NOTCH gene
BibTex
2023-10-14
R-HSA-9851127
NPM1-ALK-dependent repression of pRB phosphorylation
BibTex
2023-10-14
R-HSA-9851145
Translation of DNMT1 mRNA is repressed by miR-21
BibTex
2023-10-14
R-HSA-9851147
miR-21 RISC binds DNMT1 mRNA
BibTex
Show all authored reactions...
Reviewed Pathways (1/1)
Date
Identifier
Pathway
Reference
2016-09-17
R-HSA-3371497
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
BibTex
Show all reviewed pathways...
Reviewed Reactions (15/15)
Date
Identifier
Reaction
Reference
2016-09-17
R-HSA-5618093
ATP hydrolysis by HSP90
BibTex
2016-09-17
R-HSA-5618080
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus
BibTex
2016-09-17
R-HSA-9690534
NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-9705925
Androgens binds AR (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-9725885
P4 bind PGR (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-5618099
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
BibTex
2016-09-17
R-HSA-5618073
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
BibTex
2016-09-17
R-HSA-5618098
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein
BibTex
2016-09-17
R-HSA-5618105
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein
BibTex
2016-09-17
R-HSA-5618110
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein
BibTex
2016-09-17
R-HSA-5618085
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein
BibTex
2016-09-17
R-HSA-5618107
ATP binding to HSP90 triggers conformation change
BibTex
2016-09-17
R-HSA-3371503
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
BibTex
2016-09-17
R-HSA-3371422
ATP hydrolysis by HSP70
BibTex
2016-09-17
R-HSA-3371590
HSP70 binds to HSP40:nascent protein
BibTex
Show all reviewed reactions...
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