Karen Rothfels

Ontario Institute for Cancer Research
Authored Pathways (15/217)
Date Identifier Pathway Reference
2023-10-14 R-HSA-9851151 MDK and PTN in ALK signaling BibTex
2021-10-08 R-HSA-9755511 KEAP1-NFE2L2 pathway BibTex
2021-10-08 R-HSA-9759194 Nuclear events mediated by NFE2L2 BibTex
2021-10-08 R-HSA-9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 BibTex
2021-03-30 R-HSA-9725370 Signaling by ALK fusions and activated point mutants BibTex
2021-03-30 R-HSA-9725371 Nuclear events stimulated by ALK signaling in cancer BibTex
2021-03-30 R-HSA-9701898 STAT3 nuclear events downstream of ALK signaling BibTex
2021-03-22 R-HSA-9700206 Signaling by ALK in cancer BibTex
2021-03-22 R-HSA-9700649 Drug resistance of ALK mutants BibTex
2021-03-22 R-HSA-9717323 ceritinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717326 crizotinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717329 lorlatinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717264 ASP-3026-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717319 brigatinib-resistant ALK mutants BibTex
2021-03-22 R-HSA-9717301 NVP-TAE684-resistant ALK mutants BibTex
Authored Reactions (15/1,387)
Date Identifier Reaction Reference
2023-10-14 R-HSA-9851112 NPM1-ALK- and TYK2-dependent MCL1 gene expression BibTex
2023-10-14 R-HSA-9851114 NPM1-ALK-dependent TYK2 phosphorylation BibTex
2023-10-14 R-HSA-9851117 NPM1-ALK- and p-STAT3-dependent IRF4 gene expression BibTex
2023-10-14 R-HSA-9851118 pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK BibTex
2023-10-14 R-HSA-9851104 NPM1-ALK- and STAT3-dependent ICOS gene expression BibTex
2023-10-14 R-HSA-9851106 p-Y705, S727 STAT3 dimer binds ICOS promoter BibTex
2023-10-14 R-HSA-9851109 NPM1-ALK- and STAT3-dependent TWIST gene expression BibTex
2023-10-14 R-HSA-9851131 NPM1-ALK-stimulated PRF1 gene expression BibTex
2023-10-14 R-HSA-9851133 STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing BibTex
2023-10-14 R-HSA-9851068 Crizotinib-driven IL10RA gene expression in NPM1-ALK BibTex
2023-10-14 R-HSA-9851123 NPM1-ALK- and p-STAT3-dependent NOTCH gene expression BibTex
2023-10-14 R-HSA-9851122 p-Y705,S727 STAT3 dimer binds NOTCH gene BibTex
2023-10-14 R-HSA-9851127 NPM1-ALK-dependent repression of pRB phosphorylation BibTex
2023-10-14 R-HSA-9851145 Translation of DNMT1 mRNA is repressed by miR-21 BibTex
2023-10-14 R-HSA-9851147 miR-21 RISC binds DNMT1 mRNA BibTex
Reviewed Pathways (1/1)
Date Identifier Pathway Reference
2016-09-17 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand BibTex
Reviewed Reactions (15/15)
Date Identifier Reaction Reference
2016-09-17 R-HSA-5618093 ATP hydrolysis by HSP90 BibTex
2016-09-17 R-HSA-5618080 HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus BibTex
2016-09-17 R-HSA-9690534 NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9705925 Androgens binds AR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-9725885 P4 bind PGR (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618099 NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) BibTex
2016-09-17 R-HSA-5618073 FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein BibTex
2016-09-17 R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein BibTex
2016-09-17 R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein BibTex
2016-09-17 R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein BibTex
2016-09-17 R-HSA-5618107 ATP binding to HSP90 triggers conformation change BibTex
2016-09-17 R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein BibTex
2016-09-17 R-HSA-3371422 ATP hydrolysis by HSP70 BibTex
2016-09-17 R-HSA-3371590 HSP70 binds to HSP40:nascent protein BibTex
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