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Shamith Samarajiwa

 ORCID
https://orcid.org/0000-0003-1046-0601
Affiliation
Cancer Research UK, Cambridge Institute, University of Cambridge
Reviewed Reactions (79)
Date Identifier Reaction Reference
2013-09-03 R-HSA-3788708 CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 BibTex
2013-09-03 R-HSA-3788705 CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 BibTex
2013-09-03 R-HSA-3225867 Expression of MINK1/TNIK is positively regulated by ROS BibTex
2013-09-03 R-HSA-3229152 MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1) BibTex
2013-09-03 R-NUL-3299417 MAP3K5 (ASK1) phosphorylates Map2k4(Sek1) BibTex
2013-09-03 R-HSA-3788748 EHMT1:EHMT2 methylates IL6 promoter BibTex
2013-09-03 R-HSA-3788724 Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 BibTex
2013-09-03 R-HSA-3788725 Cdh1:APC/C complex binds EHMT1:EHMT2 BibTex
2013-09-03 R-HSA-3797202 AP-1 stimulates transcription of IGFBP7 BibTex
2013-09-03 R-HSA-3797196 AP-1 transcription factor binds IGFBP7 promoter BibTex
2013-09-03 R-HSA-3790130 Regulation of IL6 transcription BibTex
2013-09-03 R-HSA-3857305 Activated CEBPB and NFKB complex bind IL6 promoter BibTex
2013-09-03 R-HSA-4568740 AP-1 stimulates IL1A transcription BibTex
2013-09-03 R-HSA-4568737 AP-1 transcription factor binds IL1A promoter BibTex
2013-09-03 R-HSA-3790137 Stimulation of IL8 transcription in senescent cells BibTex
2013-09-03 R-HSA-3857308 Activated CEBPB and NFKB complex bind IL8 promoter BibTex
2013-09-03 R-HSA-3209165 ID1 sequesters ETS2 BibTex
2013-09-03 R-HSA-3209179 ERF inhibits ETS2 expression BibTex
2013-09-03 R-HSA-3209177 ERF binds ETS2 promoter BibTex
2013-09-03 R-HSA-6804996 p14ARF sequesters MDM2 BibTex
2013-09-03 R-HSA-6804998 p14ARF forms a ternary complex with MDM2 and TP53 BibTex
2013-09-03 R-HSA-3209111 Translation of p14ARF mRNA is inhibited by miR-24 BibTex
2013-09-03 R-HSA-3209159 Phosphorylated ERF translocates to the cytosol BibTex
2013-09-03 R-HSA-3209160 Activated ERKs phosphorylate ERF BibTex
2013-09-03 R-NUL-3245934 Mapk1 (Erk2) phosphorylates ERF BibTex
2013-09-03 R-HSA-3788745 EHMT1:EHMT2 methylates IL8 promoter BibTex
2013-09-03 R-HSA-4647594 SAHF formation BibTex
2013-09-03 R-HSA-3878123 Initiation of SAHF formation BibTex
2013-09-03 R-HSA-3239014 MAPKAPK5 phosphorylates TP53 BibTex
2013-09-03 R-HSA-3239019 Active p38 MAPK phosphorylates MAPKAPK5 BibTex
2013-09-03 R-HSA-3238999 Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 BibTex
2013-09-03 R-HSA-3785704 DSB inducing agents induce double strand DNA breaks BibTex
2013-09-03 R-HSA-3785768 MRN complex binds DNA double strand breaks BibTex
2013-09-03 R-HSA-5693612 MRN complex bound to DNA ends recruits ATM BibTex
2013-09-03 R-HSA-5693540 MRN activates ATM BibTex
2013-09-03 R-HSA-3785711 Telomere shortening during replicative exhaustion BibTex
2013-09-03 R-HSA-5682020 MRN complex binds shortened telomeres BibTex
2013-09-03 R-HSA-5682018 MRN complex bound to shortened telomeres recruits ATM BibTex
2013-09-03 R-HSA-5682026 MRN bound to shortened telomeres activates ATM BibTex
2013-09-03 R-HSA-3223236 RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) BibTex
2013-09-03 R-HSA-3225851 ROS oxidize thioredoxin and activate MAP3K5 BibTex
2013-09-03 R-HSA-3228469 MAP3K5 phosphorylates MKK3 and MKK6 BibTex
2013-09-03 R-HSA-6804879 MDM2 ubiquitinates TP53 BibTex
2013-09-03 R-HSA-6803801 TP53 in complex with ZNF385A binds the CDKN1A promoter BibTex
2013-09-03 R-HSA-3786258 TP53 binds the CDKN1A promoter BibTex
2013-09-03 R-HSA-4647593 EP400 binds CDKN1A promoter BibTex
2013-09-03 R-HSA-4647613 Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 BibTex
2013-09-03 R-HSA-3240766 E2F1/2/3:DP1/2 binds SUZ12 gene promoter BibTex
2013-09-03 R-HSA-3240787 E2F1/2/3 stimulates SUZ12 transcription BibTex
2013-09-03 R-HSA-3240777 E2F1/2/3:DP1/2 binds EZH2 gene promoter BibTex
2013-09-03 R-HSA-3240783 E2F1/2/3 stimulates EZH2 transcription BibTex
2013-09-03 R-HSA-3240765 E2F1/2/3:DP1/2 binds EED gene promoter BibTex
2013-09-03 R-HSA-3240782 E2F1/2/3 stimulates EED transcription BibTex
2013-09-03 R-HSA-3240957 Formation of PRC2-EZH2 complex BibTex
2013-09-03 R-HSA-3240295 PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter BibTex
2013-09-03 R-HSA-3222533 ERK1/2-activated AP1 complex binds KDM6B promoter BibTex
2013-09-03 R-HSA-3222546 AP-1 complex stimulates KDM6B transcription BibTex
2013-09-03 R-HSA-8979071 KDM6B binds iron BibTex
2013-09-03 R-HSA-3222593 KDM6B demethylates H3K27me3 on p16INK4A promoter BibTex
2013-09-03 R-HSA-3223200 Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription BibTex
2013-09-03 R-HSA-3132737 MAPKs phosphorylate ETS1 and ETS2 BibTex
2013-09-03 R-HSA-8979082 Phosphorylated ETS2 binds p16INK4A promoter BibTex
2013-09-03 R-HSA-3200023 Phosphorylated ETS1 binds p16INK4A promoter BibTex
2013-09-03 R-HSA-3209098 p-T38-ETS1/p-T72-ETS2 stimulates transcription of p16INK4A mRNA BibTex
2013-09-03 R-HSA-3229089 PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter BibTex
2013-09-03 R-HSA-3229102 p-MAPKAPK3 phosphorylates BMI1 BibTex
2013-09-03 R-HSA-3229138 MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription BibTex
2013-09-03 R-HSA-3209096 E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter BibTex
2013-09-03 R-HSA-3209109 E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA BibTex
2013-09-03 R-HSA-3209151 miR-24 binds p16INK4A and p14ARF mRNAs BibTex
2013-09-03 R-HSA-3209114 Translation of p16INK4A mRNA is inhibited by miR-24 BibTex
2013-09-03 R-NUL-3876071 RPS6KA1/2/3 phosphorylates Cebpb on S273 BibTex
2013-09-03 R-HSA-3858387 Activated STAT3 positively regulates CEBPB transcription BibTex
2013-09-03 R-HSA-3857329 MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB BibTex
2013-09-03 R-HSA-3857328 RPS6KA1/2/3 phosphorylates CEBPB on S321 BibTex
2013-09-03 R-HSA-3857336 CEBPB homodimerization BibTex
2013-09-03 R-HSA-3857345 Activated CEBPB binds CDKN2B promoter BibTex
2013-09-03 R-HSA-3857348 Activated CEBPB stimulates transcription of CDKN2B BibTex
2013-09-03 R-HSA-182594 Association of INK4 family proteins with CDK4/6 BibTex