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Jan Willem N Akkerman

 ORCID
Affiliation
University Medical Center Utrecht, Department of Clinical Chemistry and Haematology
Authored Reactions (158)
Date Identifier Reaction Reference
2010-10-29 R-HSA-992708 Dual-specific AKAPs bind type I and II PKA regulatory subunits BibTex
2010-10-29 R-HSA-2267372 ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 BibTex
2010-10-29 R-HSA-994140 ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 BibTex
2010-10-29 R-HSA-994137 ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 BibTex
2010-10-29 R-HSA-990478 Kinesin-14 is a dimer BibTex
2010-10-29 R-DME-990504 Ncd is a dimer BibTex
2010-10-29 R-HSA-984648 Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin BibTex
2010-10-29 R-HSA-984775 Kinesin-9 is a dimer BibTex
2010-10-29 R-MMU-984753 Kinesin-9 is a dimer BibTex
2010-10-29 R-HSA-984708 Kinesin-2 is a heterotrimer BibTex
2010-10-29 R-MMU-984713 Kinesin-2 is a heterotrimer BibTex
2010-10-29 R-HSA-983266 Kinesins bind microtubules BibTex
2010-10-29 R-HSA-984671 Chromokinesins form dimers BibTex
2010-10-29 R-HSA-984689 Kinesin-7 is a dimer BibTex
2010-10-29 R-HSA-984733 Kinesin-3 is a dimer BibTex
2010-10-29 R-HSA-983194 Kinesin-1 is a heterotetramer BibTex
2010-10-29 R-HSA-990489 Kinesin-13 is a dimer BibTex
2010-10-29 R-HSA-984606 Kinesin-5 is a homotetramer BibTex
2010-10-29 R-HSA-984821 Kinesin-12 is a dimer BibTex
2010-10-29 R-XLA-984820 Xenopus kinesin-12 is a dimer BibTex
2010-10-29 R-HSA-984609 Kinesin-8 is a dimer BibTex
2010-10-29 R-SPO-984665 Kinesin-8 is a dimer BibTex
2010-10-29 R-HSA-983259 Kinesins move along microtubules consuming ATP BibTex
2010-10-29 R-HSA-994020 IRF1 binds the promoters of Interferon alpha and beta BibTex
2010-10-29 R-HSA-994148 LRRC16A binds F-actin capping protein BibTex
2010-10-29 R-HSA-879459 F-actin capping protein is a heterodimer BibTex
2010-10-29 R-HSA-992703 Mitofusins trans-interact linking mitochondria prior to fusion BibTex
2010-10-29 R-HSA-994106 HP1 alpha binds Histone H3K9(me)3 BibTex
2010-10-29 R-HSA-994169 F-actin capping protein binds to the barbed end of elongating F-actin BibTex
2010-10-29 R-NUL-994158 F-actin capping protein binds to elongating F-actin BibTex
2010-10-29 R-HSA-992696 p53, SIN3A and MYB form a complex BibTex
2010-10-29 R-NUL-992753 p53 and Sin3a bind c-Myb BibTex
2010-10-29 R-HSA-994038 IRF2 binds the promoters of Interferon alpha and beta BibTex
2010-10-29 R-HSA-983285 RAD51B binds RAD51C BibTex
2010-10-29 R-HSA-983218 RAD51B:RAD51C binds single-stranded DNA BibTex
2010-10-29 R-HSA-994034 Expression of Interferon-alpha and beta BibTex
2009-09-04 R-HSA-453183 p-Y348-SYK dissociates BibTex
2009-09-04 R-HSA-453200 SYK autophosphorylates BibTex
2009-09-04 R-HSA-397835 Dissociation of the PAR:Gq complex BibTex
2009-09-04 R-HSA-397891 Dissociation of the PAR:G12/13 complex BibTex
2009-09-04 R-HSA-432148 Fgr may phosphorylate p38 MAPK BibTex
2009-09-04 R-HSA-432129 FGR binds and phosphorylates LRP8 BibTex
2009-09-04 R-HSA-8948034 FGR binds LDL:LRP8 BibTex
2009-09-04 R-HSA-432121 LDL binds to LRP8 BibTex
2009-09-04 R-HSA-434798 CRAC translocates calcium from the extracellular region to the cytosol BibTex
2009-09-04 R-DME-434802 Calcium influx via CRAC BibTex
2009-09-04 R-HSA-434700 STIM1 activation of CRAC BibTex
2009-09-04 R-DME-434702 Stim activation of CRAC BibTex
2009-09-04 R-HSA-437162 PI3K alpha, beta, gamma convert PIP2 to PIP3 BibTex
2009-09-04 R-HSA-437118 GPVI stimulates PI3K beta, gamma BibTex
2009-09-04 R-HSA-442291 VAV2 is a GEF for Rho/Rac family kinases BibTex
2009-09-04 R-HSA-437936 p-Y348-SYK phosphorylates VAV family BibTex
2009-09-04 R-NUL-437938 Syk phosphorylates VAV1 BibTex
2009-09-04 R-HSA-437932 p-Y348-SYK binds VAV family BibTex
2009-09-04 R-MMU-442289 Syk binds Vav2 BibTex
2009-09-04 R-NUL-437945 Pig Syk binds human Vav1 BibTex
2009-09-04 R-HSA-442314 VAV3 is a GEF for Rho/Rac family kinases BibTex
2009-09-04 R-HSA-434637 PIP3 binds stimulating VAV BibTex
2009-09-04 R-MMU-434629 PIP3 stimulates Vav1 BibTex
2009-09-04 R-HSA-437195 PDPK1 activates PRKCZ BibTex
2009-09-04 R-RNO-437185 PDK1 activates PKC zeta BibTex
2009-09-04 R-HSA-437192 PDPK1 binds PRKCZ BibTex
2009-09-04 R-RNO-437189 PDK1 binds PKC zeta BibTex
2009-09-04 R-HSA-435244 PECAM1 is phosphorylated BibTex
2009-09-04 R-HSA-443831 14-3-3-zeta binds Raf1 BibTex
2009-09-04 R-HSA-443439 c-Src binds Raf1 BibTex
2009-09-04 R-HSA-443418 GP1b signaling involves c-Src BibTex
2009-09-04 R-HSA-443402 GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K BibTex
2009-09-04 R-HSA-443926 Thrombopoietin binds the thrombopoietin receptor BibTex
2009-09-04 R-NUL-443942 Thrombopoietin binds the thrombopoietin receptor BibTex
2009-09-04 R-HSA-443910 SHC1 dissociates from integrin alphaIIb beta3 BibTex
2009-09-04 R-HSA-443905 SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow BibTex
2009-09-04 R-HSA-432096 Activated integrin alphaIIb beta3 binds SHC1 BibTex
2009-09-04 R-HSA-432110 Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding BibTex
2009-09-04 R-HSA-434633 PIP2 binds inhibiting VAV BibTex
2009-09-04 R-MMU-434634 PIP2 inhibits Vav1 BibTex
2009-09-04 R-HSA-434836 Syk/Lck phosphorylate LAT BibTex
2009-09-04 R-HSA-442273 VAV1 is a GEF for Rho/Rac family GTPases BibTex
2009-09-04 R-HSA-432143 PECAM-1 binds PP2A BibTex
2009-06-03 R-HSA-429497 SLP-76 stimulates PLC gamma 2 BibTex
2009-06-03 R-HSA-429449 Syk activation leads to SLP-76 activation BibTex
2009-06-03 R-HSA-432295 GPVI binds Fyn and Lyn BibTex
2009-06-03 R-HSA-418576 Dissociation of the P2Y purinoceptor 1:Gq complex BibTex
2009-06-03 R-HSA-418579 Gq activation by P2Y purinoceptor 1 BibTex
2009-06-03 R-NUL-428715 Activated human P2Y purinoceptor 1 binds mouse G-protein Gq BibTex
2009-06-03 R-HSA-418581 Activated P2Y purinoceptor 1 binds G-protein Gq BibTex
2009-06-03 R-HSA-392202 Dissociation of the P2Y purinoceptor 12:Gi complex BibTex
2009-06-03 R-HSA-392195 Gi activation by P2Y purinoceptor 12 BibTex
2009-06-03 R-HSA-392187 Activated P2Y purinoceptor 12 binds G-protein Gi BibTex
2009-06-03 R-HSA-396996 Thrombin-activated PAR binds G-protein Gq BibTex
2009-06-03 R-HSA-396941 Thrombin-activated PAR binds G-protein G12/13 BibTex
2009-06-03 R-MMU-427858 Thrombin-activated PAR binds G-protein G12/13 BibTex
2009-06-03 R-HSA-428961 Phosphorylation of cPLA2 by MAPK p38 alpha BibTex
2009-06-03 R-HSA-428941 P2Y purinoceptor 1 activates MAP kinase p38 alpha BibTex
2009-06-03 R-HSA-392874 Dissociation of the Prostacyclin receptor:Gs complex BibTex
2009-06-03 R-HSA-392870 Gs activation by prostacyclin receptor BibTex
2009-06-03 R-HSA-392852 Activated prostacyclin receptor binds G-protein Gs BibTex
2009-06-03 R-HSA-419232 Myosin phosphatase dephosphorylates myosin regulatory light chain BibTex
2009-06-03 R-MGA-421635 Myosin phosphatase dephosphorylates myosin regulatory light chain BibTex
2009-06-03 R-HSA-419197 Myosin regulatory light chain phosphorylation by ROCK BibTex
2009-06-03 R-NUL-421724 Myosin regulatory light chain phosphorylation by Rock2 BibTex
2009-06-03 R-HSA-419049 ROCK activation by RHO BibTex
2009-06-03 R-HSA-428918 Dissociation of the TP:G13 complex BibTex
2009-06-03 R-HSA-428917 G13 activation by TP receptor BibTex
2009-06-03 R-HSA-428909 Activated TP receptor binds G-protein G13 BibTex
2009-06-03 R-HSA-430180 NCK recruits WASP BibTex
2009-06-03 R-HSA-419087 LIM kinase phosphorylation by ROCK BibTex
2009-06-03 R-NUL-421733 ROCK1 phosphorylates LIMK2 (rat) BibTex
2009-06-03 R-HSA-419083 Myosin phosphatase inactivation by ROCK BibTex
2009-06-03 R-NUL-421062 Myosin phosphatase inactivation by ROCK2 BibTex
2009-06-03 R-HSA-430135 p-SLP-76 binds ADAP BibTex
2009-06-03 R-HSA-430183 NCK binds PAK BibTex
2009-06-03 R-HSA-430190 p-SLP-76 binds NCK BibTex
2009-06-03 R-HSA-430201 p-SLP-76:ADAP binds Ena/VASP BibTex
2009-06-03 R-MMU-430200 p-SLP-76:ADAP binds Ena/VASP BibTex
2009-06-03 R-HSA-418436 Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) BibTex
2009-06-03 R-HSA-428752 Dissociation of the TP:Gq complex BibTex
2009-06-03 R-HSA-428750 Gq activation by TP receptor BibTex
2009-06-03 R-HSA-428749 Activated TP receptor binds G-proten Gq BibTex
2009-06-03 R-HSA-425861 Activation of Protein Kinase C novel isoforms BibTex
2009-06-03 R-HSA-426209 DAG activation of TRPC channels BibTex
2009-06-03 R-HSA-392831 Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) BibTex
2009-06-03 R-HSA-430076 GP1b-IX-V binds 14-3-3-zeta BibTex
2009-06-03 R-HSA-430096 GP1b-IX-V binds filamin BibTex
2009-06-03 R-HSA-430073 GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress BibTex
2009-06-03 R-HSA-418662 Src activation following P2Y purinoceptor activation BibTex
2009-06-03 R-HSA-429157 ABCC4 accumulation of dense granule contents BibTex
2009-06-03 R-HSA-419490 Binding of ATP to P2X receptors BibTex
2009-06-03 R-HSA-426223 Cation influx mediated by TRPC3/6/7 BibTex
2009-06-03 R-HSA-418176 Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex BibTex
2009-06-03 R-HSA-418172 Activated PAR1 binds beta-arrestin-2 BibTex
2009-06-03 R-HSA-418158 Activation of beta-arrestin-1-bound Src kinase BibTex
2009-06-03 R-HSA-418170 Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex BibTex
2009-06-03 R-HSA-418091 Activated PAR1 binds Beta-arrestin-1 BibTex
2009-06-03 R-HSA-418163 Activated Src activates ERK BibTex
2009-06-03 R-HSA-418200 Src bound to beta-arrestin-2 is not activated BibTex
2009-06-03 R-HSA-392834 Activation of EPACs by cAMP BibTex
2009-06-03 R-HSA-429415 SYK binds to integrin alphaIIb beta3 BibTex
2009-06-03 R-HSA-429441 SYK activation by SRC BibTex
2009-06-03 R-HSA-429529 Thrombin binding to GP1b:IX:V BibTex
2009-06-03 R-HSA-430158 p-SLP-76 binds VAV BibTex
2009-06-03 R-HSA-418309 ATP2B1-4 transport cytosolic Ca2+ to extracellular region BibTex
2009-06-03 R-HSA-418365 ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen BibTex
2009-06-03 R-HSA-392143 NO binds to Guanylate Cyclase BibTex
2009-06-03 R-RNO-427279 NO binds to Guanylate Cyclase BibTex
2009-06-03 R-HSA-392152 Soluble guanylate cyclase converts GTP to cGMP BibTex
2009-06-03 R-RNO-427288 Soluble guanylate cyclase converts GTP to cGMP BibTex
2009-06-03 R-HSA-418549 PKG1 phosphorylates BK channels BibTex
2009-06-03 R-NUL-427888 PKG1a phosphorylates BK channels BibTex
2009-06-03 R-HSA-418451 cGMP stimulates Protein Kinase G BibTex
2009-06-03 R-HAM-427308 cGMP stimulates Protein Kinase G BibTex
2009-06-03 R-HSA-418442 PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release BibTex
2009-06-03 R-HSA-418456 cGMP is degraded by PDEs BibTex
2009-06-03 R-HSA-913996 PKA/PKG phosphorylate Rap1GAP2 BibTex
2009-06-03 R-HSA-913993 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 BibTex
2009-06-03 R-HSA-392513 Rap1 signal termination by Rap1GAPs BibTex
2009-06-03 R-HSA-392835 Rap1 sequesters Raf1 to inhibit ERK cascade BibTex
2009-06-03 R-HSA-427910 ATP2A1-3 transport Ca2+ from cytosol to ER lumen BibTex