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Yoshiaki Ito

 ORCID
Affiliation
Cancer Science Institute of Singapore, National University of Singapore
Reviewed Reactions (192)
Date Identifier Reaction Reference
2014-01-22 R-HSA-4411357 TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene BibTex
2014-01-22 R-HSA-4411367 TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene BibTex
2017-01-31 R-HSA-8951428 RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) BibTex
2017-01-31 R-HSA-8937814 RUNX3 translocates to the nucleus BibTex
2012-02-06 R-HSA-1980047 NOTCH1 stimulates HES1 transcription BibTex
2012-02-06 R-HSA-4396347 NOTCH1 Coactivator Complex binds HES1 promoter BibTex
2009-06-08 R-HSA-1989766 Expression of CTGF BibTex
2017-01-31 R-HSA-8951695 TEADs:YAP1 binds CTGF gene BibTex
2017-01-31 R-HSA-8951676 RUNX3 binds TEADs and YAP1 BibTex
2017-01-31 R-HSA-8952442 SPP1 gene expression is stimulated by RUNX3 BibTex
2017-01-31 R-HSA-8865454 CBFB binds RUNX3 BibTex
2017-01-31 R-HSA-8949276 RUNX3:CBFB binds the RORC gene promoter BibTex
2017-01-31 R-MMU-8949284 Runx3:Cbfb binds the Rorc gene promoter BibTex
2017-01-31 R-HSA-8949343 ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB BibTex
2017-01-31 R-HSA-8949335 RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter BibTex
2017-01-31 R-HSA-8949301 RORC gene expression is stimulated by RUNX3:CBFB BibTex
2017-01-31 R-MMU-8949303 Rorc gene expression is stimulated by Runx3:Cbfb BibTex
2017-01-31 R-HSA-8952232 BCL2L11 (BIM) gene transcription is stimulated by RUNX3 BibTex
2017-01-31 R-HSA-8952226 RUNX3 binds the BCL2L11 (BIM) gene BibTex
2017-01-31 R-HSA-8878143 RUNX3 binds SMAD3 and SMAD4 BibTex
2017-01-31 R-HSA-8878117 RUNX3 binds ZFHX3 BibTex
2017-01-31 R-HSA-8878178 The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter BibTex
2017-01-31 R-HSA-8878130 CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3 BibTex
2017-01-31 R-HSA-8952128 RUNX3 binds TP53 BibTex
2017-01-31 R-HSA-8878186 CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4 BibTex
2017-01-31 R-HSA-8878212 JAG1 gene expression is inhibited by RUNX3 BibTex
2017-01-31 R-HSA-8878193 RUNX3 binds the JAG1 gene promoter BibTex
2017-01-31 R-HSA-8878243 HES1 gene transcription is inhibited by RUNX3 BibTex
2017-01-31 R-HSA-8878237 RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter BibTex
2017-01-31 R-HSA-8878220 RUNX3 binds the NOTCH1 coactivator complex BibTex
2017-01-31 R-HSA-8951977 Acetylated RUNX3 binds to BRD2 BibTex
2017-01-31 R-HSA-8951966 EP300 acetylates RUNX3 BibTex
2017-01-31 R-HSA-8951951 RUNX3 binds EP300 BibTex
2017-01-31 R-HSA-8952058 CCND1 binds RUNX3 and displaces EP300 BibTex
2017-01-31 R-HSA-8952062 CCND1 recruits HDAC4 to RUNX3 BibTex
2017-01-31 R-HSA-8952081 RUNX proteins bind the p14-ARF promoter at the CDKN2A locus BibTex
2017-01-31 R-HSA-8952101 p14-ARF transcription is stimulated by RUNX proteins BibTex
2017-01-31 R-HSA-8952069 HDAC4 deacetylates RUNX3 BibTex
2017-01-31 R-HSA-8952408 Polyubiquitinated RUNX3 is degraded by the proteasome BibTex
2017-01-31 R-HSA-8952399 Polyubiquitinated RUNX3 translocates to the cytosol BibTex
2017-01-31 R-HSA-8952382 MDM2 polyubiquitinates RUNX3 BibTex
2017-01-31 R-HSA-8952371 MDM2 binds RUNX3 BibTex
2017-01-31 R-HSA-8937807 SRC phosphorylates RUNX3 BibTex
2017-01-31 R-HSA-8937792 RUNX3 binds SRC BibTex
2017-01-31 R-HSA-8952419 SMURFs ubiquitinate RUNX3 BibTex
2017-01-31 R-HSA-8951442 CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter BibTex
2017-01-31 R-HSA-8951443 Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 BibTex
2017-01-31 R-HSA-8951910 RUNX3 binds the RUNX1 promoter BibTex
2017-01-31 R-HSA-8951926 RUNX1 gene expression is inhibited by RUNX3 BibTex
2016-12-20 R-MMU-6807098 Nr2e1 represses Pten transcription BibTex
2016-12-20 R-MMU-6807090 Nr2e1 binds Pten promoter BibTex
2016-12-20 R-HSA-8938853 CDK6 binds RUNX1 BibTex
2016-12-20 R-HSA-8865320 CBFB binds RUNX1 BibTex
2016-12-20 R-HSA-8935785 RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 BibTex
2016-12-20 R-HSA-8935864 miR-302b binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8938440 miR-17 binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8939129 miR-215 binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8935930 miR-18a binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8936058 miR-675 binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8936068 H19 is cleaved to produce miR-675 BibTex
2016-12-20 R-HSA-8938507 miR-106a binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8937134 miR-27a binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8935766 miR-378 binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8938487 miR-20a binds RUNX1 mRNA BibTex
2016-12-20 R-HSA-8938867 CCND3,(CCND1,CCND2) binds RUNX1 BibTex
2016-12-20 R-HSA-8938887 PML binds RUNX1 BibTex
2016-12-20 R-HSA-8937728 SRC phosphorylates RUNX1 BibTex
2016-12-20 R-MMU-8937738 Src phosphorylates Runx1 BibTex
2016-12-20 R-HSA-8937682 RUNX1 binds SRC BibTex
2016-12-20 R-MMU-8937703 Runx1 binds Src BibTex
2016-12-20 R-HSA-8937767 PTPN11 dephosphorylates RUNX1 BibTex
2016-12-20 R-HSA-8937744 PTPN11 binds p-7Y-RUNX1 BibTex
2016-12-20 R-HSA-8877879 RUNX1 and FOXP3 bind the RSPO3 gene promoter BibTex
2016-12-20 R-HSA-8932076 AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 BibTex
2016-12-20 R-HSA-8932070 ESR1 binds the AXIN1 gene BibTex
2016-12-20 R-HSA-8877884 RUNX1 and FOXP3 stimulate the RSPO3 gene expression BibTex
2016-12-20 R-HSA-8932084 RUNX1 and ESR1 bind the AXIN1 gene BibTex
2016-12-20 R-HSA-8931981 RUNX1 binds ESR1 BibTex
2016-12-20 R-HSA-8938121 SERPINB13 binds CTSK BibTex
2016-12-20 R-HSA-8938063 SERPINB13 gene expression is inhibited by RUNX1:CBFB BibTex
2016-12-20 R-HSA-8938053 RUNX1:CBFB binds the SERPINB13 gene promoter BibTex
2016-12-20 R-HSA-8938108 SERPINB13 binds cathepsin L BibTex
2016-12-20 R-HSA-8955885 SOCS3 gene expression is inhibited by RUNX1 BibTex
2016-12-20 R-MMU-8955856 Socs3 gene expression is inhibited by Runx1 BibTex
2016-12-20 R-MMU-8955743 Runx1 binds the Socs3 gene BibTex
2016-12-20 R-HSA-8955748 RUNX1 binds the SOCS3 gene BibTex
2016-12-20 R-HSA-8955822 RUNX1 binds the SOCS4 gene BibTex
2016-12-20 R-MMU-8955833 Runx1 binds the Socs4 gene BibTex
2016-12-20 R-HSA-8955893 SOCS4 gene expression is inhibited by RUNX1 BibTex
2016-12-20 R-MMU-8955894 Socs4 gene expression is inhibited by Runx1 BibTex
2016-12-20 R-HSA-8936584 PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter BibTex
2016-12-20 R-HSA-8935730 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter BibTex
2016-12-20 R-HSA-8935732 RUNX1 binds SIN3A,(SIN3B) co-repressor BibTex
2016-12-20 R-HSA-8937097 MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 BibTex
2016-12-20 R-HSA-8937037 RUNX1 and GATA1 bind the promoter of the MIR27A gene BibTex
2016-12-20 R-HSA-8934735 PRMT1 arginine-methylates RUNX1 BibTex
2016-12-20 R-HSA-8934742 RUNX1 binds PRMT1 BibTex
2016-12-20 R-HSA-8938176 RUNX1:CBFB binds the PF4 gene promoter BibTex
2016-12-20 R-HSA-8938328 RUNX1:CBFB binds the NFE2 gene promoter BibTex
2016-12-20 R-HSA-8937113 PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter BibTex
2016-12-20 R-HSA-8937118 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter BibTex
2016-12-20 R-HSA-8938201 MYL9 gene transcription is stimulated by RUNX1:CBFB BibTex
2016-12-20 R-HSA-8938199 RUNX1:CBFB binds the MYL9 gene promoter BibTex
2016-12-20 R-HSA-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter BibTex
2016-12-20 R-HSA-8936989 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter BibTex
2016-12-20 R-HSA-8936979 RUNX1 and GATA1 bind the promoter of the THBS1 gene BibTex
2016-12-20 R-HSA-8936599 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter BibTex
2016-12-20 R-HSA-8936616 RUNX1 and GATA1 bind the promoter of the GP1BA gene BibTex
2016-12-20 R-HSA-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter BibTex
2016-12-20 R-HSA-8938158 PRKCQ gene expression is stimulated by RUNX1:CBFB BibTex
2016-12-20 R-HSA-8938150 RUNX1:CBFB binds the PRKCQ gene promoter BibTex
2016-12-20 R-HSA-8936608 PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter BibTex
2016-12-20 R-HSA-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter BibTex
2016-12-20 R-HSA-8935740 RUNX1 and GATA1 bind the promoter of the ITGA2B gene BibTex
2016-12-20 R-HSA-8938338 NFE2 gene expression is stimulated by RUNX1:CBFB BibTex
2016-12-20 R-HSA-8936995 THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 BibTex
2016-12-20 R-HSA-8938022 RUNX1:CBFB binds the NR4A3 gene promoter BibTex
2016-12-20 R-HSA-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter BibTex
2016-12-20 R-HSA-8937022 PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter BibTex
2016-12-20 R-HSA-8938174 PF4 gene transcription is stimulated by RUNX1:CBFB BibTex
2016-12-20 R-HSA-8938034 NR4A3 gene expression is stimulated by RUNX1:CBFB BibTex
2016-12-20 R-HSA-8935731 ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 BibTex
2016-12-20 R-HSA-8936628 GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 BibTex
2016-12-20 R-HSA-8938930 RUNX1 binds ELF2 BibTex
2016-12-20 R-HSA-8938951 RUNX1 binds PAX5 (BSAP) BibTex
2016-12-20 R-HSA-8938987 BLK gene expression is stimulated by the complex of RUNX1 and ELF1, ELF2 or PAX5 BibTex
2016-12-20 R-HSA-8938965 RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter BibTex
2016-12-20 R-HSA-8938913 RUNX1 binds ELF1 BibTex
2016-12-20 R-HSA-8932033 KCTD6 gene expression is stimulated by RUNX1 and ESR1 BibTex
2016-12-20 R-HSA-8932037 RUNX1 and ESR1 bind the KCTD6 gene enhancer BibTex
2016-12-20 R-HSA-8932020 GPAM gene expression is stimulated by RUNX1 and ESR1 BibTex
2016-12-20 R-HSA-8932021 RUNX1 and ESR1 bind the GPAM gene enhancer BibTex
2016-12-20 R-HSA-8878056 RUNX1:CBFB binds EP300 BibTex
2016-12-20 R-HSA-8878050 HIPK2 phosphorylates RUNX1 and EP300 BibTex
2016-12-20 R-HSA-8878054 HIPK2 phosphorylates RUNX1 BibTex
2016-12-20 R-HSA-8937989 RUNX1 binds PRC1 complexes BibTex
2016-12-20 R-HSA-8938217 RUNX1 binds the SWI/SNF complex BibTex
2016-12-20 R-HSA-8938938 RUNX1 and ELF1 bind the IL3 gene promoter BibTex
2016-12-20 R-HSA-8934688 RUNX1:CBFB binds the LIFR gene promoter BibTex
2016-12-20 R-HSA-8934690 LIFR gene expression BibTex
2016-12-20 R-HSA-8938981 IL3 gene transcription is stimulated by RUNX1 and ELF1 BibTex
2016-12-20 R-HSA-8938231 RUNX1:CBFB binds CREBBP BibTex
2016-12-20 R-HSA-8939066 PRKCB gene expression is stimulated by RUNX1 BibTex
2016-12-20 R-HSA-8939054 RUNX1 binds the PRKCB gene promoter BibTex
2016-12-20 R-HSA-8938251 CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP BibTex
2016-12-20 R-HSA-8938228 RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter BibTex
2016-12-20 R-HSA-8938382 LGALS3 gene expression is stimulated by RUNX1 and RUNX2 BibTex
2016-12-20 R-HSA-8938389 RUNX1:CBFB binds the LGALS3 gene promoter BibTex
2016-12-20 R-HSA-8957241 TP73 tetramer translocates to the nucleus BibTex
2016-12-20 R-HSA-8956676 YAP1 binds TP73 BibTex
2016-12-20 R-HSA-8956659 ABL1 phosphorylates YAP1 BibTex
2016-12-20 R-HSA-8957265 26S proteasome degrades TP73 polyubiquitinated by ITCH BibTex
2016-12-20 R-HSA-8956684 ITCH polyubiquitinates TP73 BibTex
2016-12-20 R-HSA-8956568 RUNX1 binds the core TAL1 complex BibTex
2016-12-20 R-HSA-8865482 KMT2A (MLL) binds RUNX1 BibTex
2016-12-20 R-HSA-8956639 RUNX1 binds YAP1 BibTex
2016-12-20 R-HSA-8956649 The complex of RUNX1 and YAP1 binds the ITCH gene promoter BibTex
2016-12-20 R-HSA-8956586 RUNX1-containing TAL1 complex binds the MYB gene enhancer BibTex
2016-12-20 R-HSA-8956652 ITCH gene expression is stimulated by RUNX1 and YAP1 BibTex
2016-12-20 R-HSA-8865505 SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A BibTex
2016-12-20 R-NUL-8865529 Spi1 gene transcription is stimulated by RUNX1:Cbfb:KMT2A BibTex
2016-12-20 R-HSA-8865498 KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark BibTex
2016-12-20 R-NUL-8865525 KTM2A trimethylates nucleosomes at the Spi1 gene locus producing H3K4Me3 mark BibTex
2016-12-20 R-HSA-8865491 RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene BibTex
2016-12-20 R-NUL-8865513 RUNX1 recruits KMT2A to the Spi1 gene BibTex
2016-12-20 R-HSA-8956608 MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex BibTex
2016-12-20 R-HSA-8877192 RUNX1 binds FOXP3 BibTex
2016-12-20 R-HSA-8865546 FOXP3 gene expression is stimulated by RUNX1:CBFB BibTex
2016-12-20 R-HSA-8865547 RUNX1:CBFB binds FOXP3 gene BibTex
2016-12-20 R-HSA-8877414 FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter BibTex
2016-12-20 R-HSA-8939082 RUNX1 binds the CR1 gene promoter BibTex
2016-12-20 R-HSA-8877348 RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter BibTex
2016-12-20 R-HSA-8877345 IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 BibTex
2016-12-20 R-HSA-8877338 RUNX1 and NFATC2 bind the IL2 gene promoter BibTex
2016-12-20 R-HSA-8877391 FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene BibTex
2016-12-20 R-HSA-8877421 CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1 BibTex
2016-12-20 R-HSA-8877404 RUNX1 binds the promoter of the CTLA4 gene BibTex
2016-12-20 R-HSA-8877485 RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 BibTex
2016-12-20 R-HSA-8877385 RUNX1 binds intron 1 of IL2RA (CD25) gene BibTex
2016-12-20 R-HSA-8877493 TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 BibTex
2016-12-20 R-HSA-8877490 FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 BibTex
2016-12-20 R-HSA-8877396 IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1 BibTex
2016-12-20 R-HSA-8877360 RUNX1 binds the IFNG promoter BibTex
2016-12-20 R-HSA-8939088 CR1 gene expression is stimulated by RUNX1 BibTex
2016-12-20 R-HSA-8877369 RUNX1 and FOXP3 bind the IFNG gene BibTex
2016-12-20 R-HSA-9006422 IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3 BibTex
2016-12-20 R-HSA-8935960 RUNX1 binds the TJP1 (ZO-1) gene promoter BibTex
2016-12-20 R-HSA-8935980 RUNX1 binds the OCLN gene promoter BibTex
2016-12-20 R-HSA-8936000 RUNX1 binds the CLDN5 (Claudin-5) gene promoter BibTex
2016-12-20 R-HSA-8935972 TJP1 (ZO-1) gene expression is stimulated by RUNX1 BibTex
2016-12-20 R-HSA-8935988 OCLN (Occludin) gene expression is stimulated by RUNX1 BibTex
2016-12-20 R-HSA-8936007 CLDN5 (Claudin-5) gene expression is stimulated by RUNX1 BibTex