Bruce May

 ORCID
https://orcid.org/0000-0001-5193-0855
Project
Reactome
Affiliation
Cold Spring Harbor Laboratory
Authored Pathways (15/247)
Date Identifier Pathway Reference
2025-06-06 R-HSA-9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide BibTex
2025-06-06 R-HSA-9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA BibTex
2025-06-06 R-HSA-9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA BibTex
2025-05-19 R-HSA-9948299 Ribosome-associated quality control BibTex
2025-04-12 R-HSA-9945266 Differentiation of T cells BibTex
2025-03-17 R-HSA-9942503 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) BibTex
2025-01-29 R-HSA-9937383 Mitochondrial ribosome-associated quality control BibTex
2025-01-25 R-HSA-9937008 Mitochondrial mRNA modification BibTex
2024-12-28 R-HSA-9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression BibTex
2024-12-17 R-HSA-9932298 Degradation of CRY and PER proteins BibTex
2024-12-09 R-HSA-9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes BibTex
2024-12-09 R-HSA-9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 BibTex
2024-12-09 R-HSA-9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex BibTex
2024-12-09 R-HSA-9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex BibTex
2024-12-09 R-HSA-9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK BibTex
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Authored Reactions (15/2,659)
Date Identifier Reaction Reference
2025-06-09 R-HSA-9955731 ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide BibTex
2025-06-09 R-HSA-9954919 ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released BibTex
2025-06-06 R-HSA-9954737 RCHY1 K48 polyubiquitinates alanine-tailed nascent peptide BibTex
2025-06-06 R-HSA-9954727 RCHY1 binds alanine-tailed nascent peptide and Ub:UBE2D2 BibTex
2025-06-06 R-HSA-9954723 NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide BibTex
2025-06-06 R-HSA-9954721 NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide BibTex
2025-06-06 R-HSA-9954728 The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide BibTex
2025-06-06 R-HSA-9954730 PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide BibTex
2025-05-28 R-SCE-9953094 The proteasome degrades the K48-polyUb nascent peptide-Ala-Thr bound to RKR1:RQC2:RQC1:CDC48 hexamer BibTex
2025-05-27 R-SCE-9950045 CDC48 hexamer, UFD1, and NPL4 bind K48polyubiquitin of RKR1:RQC2:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide BibTex
2025-05-27 R-SCE-9950051 CDC48 extracts K48 polyubiquitinated Ala-Thr-tailed nascent peptide from CDC48 hexamer:UFD1:NPL4:RKR1:RQC2:RQC1:60S ribosome subunit:K48polyUb-nascent peptide-Ala-Thr BibTex
2025-05-24 R-HSA-9949676 The proteasome degrades the alanine-tailed K48-polyUb nascent peptide bound to LTN1:NEMF:TCF25:VCP hexamer BibTex
2025-05-22 R-HSA-9949632 VCP hexamer extracts K48 polyubiquitinated alanine-tailed nascent peptide from VCP hexamer:UFD1:NPLOC4:LTN1:NEMF:TCF25:60S ribosome subunit:K48polyUb-nascent peptide BibTex
2025-05-20 R-HSA-9948458 NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide ("CAT tailing") BibTex
2025-05-20 R-HSA-9948415 VCP hexamer and NPLOC4:UFD1 bind K48polyubiquitin of LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide BibTex
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Reviewed Pathways (11/11)
Date Identifier Pathway Reference
2025-06-02 R-HSA-1474244 Extracellular matrix organization BibTex
2025-06-02 R-HSA-1566977 Fibronectin matrix formation BibTex
2025-02-26 R-HSA-8953854 Metabolism of RNA BibTex
2024-05-23 R-HSA-5578749 Transcriptional regulation by small RNAs BibTex
2024-02-28 R-HSA-1266738 Developmental Biology BibTex
2022-08-06 R-HSA-9793242 SUMOylation of nuclear envelope proteins BibTex
2020-01-09 R-HSA-9673163 Oleoyl-phe metabolism BibTex
2015-10-04 R-HSA-3232118 SUMOylation of transcription factors BibTex
2014-01-31 R-HSA-5250941 Negative epigenetic regulation of rRNA expression BibTex
2013-01-12 R-HSA-2980736 Peptide hormone metabolism BibTex
2011-08-18 R-HSA-1433617 Regulation of signaling by NODAL BibTex
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Reviewed Reactions (15/58)
Date Identifier Reaction Reference
2025-06-08 R-HSA-450466 AUF1:mRNA complex is degraded BibTex
2025-06-08 R-HSA-1168640 Ubiquitinated IkB is degraded BibTex
2025-06-02 R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA BibTex
2025-06-02 R-HSA-5419271 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed BibTex
2025-06-02 R-HSA-2213248 Transport of antigen loaded MHC II molecules to surface BibTex
2025-06-02 R-HSA-6782443 QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) BibTex
2025-06-02 R-HSA-6787567 TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser) BibTex
2024-05-23 R-HSA-877198 P2X7 mediates membrane pores that include pannexin-1 BibTex
2024-02-28 R-HSA-9024159 FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe) BibTex
2024-02-28 R-HSA-9024161 FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe) BibTex
2023-05-12 R-HSA-9820538 MSGN1 binds the TBX6 gene BibTex
2023-05-12 R-MMU-9820540 Msgn1 binds the Tbx6 gene BibTex
2023-05-12 R-HSA-9824181 Expression of LFNG in presomitic mesoderm BibTex
2023-05-12 R-HSA-9824182 RBPJ:NICD1 and MSGN1 bind the LFNG gene BibTex
2023-05-12 R-MMU-9824231 Rbpj:Nicd and Msgn1 bind the Lfng gene BibTex
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