Akira Kikuchi

Authored Pathways (3/3)
Date Identifier Pathway Reference
2014-04-22 R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins BibTex
2013-11-13 R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 BibTex
2013-11-13 R-HSA-5099900 WNT5A-dependent internalization of FZD4 BibTex
Authored Reactions (14/14)
Date Identifier Reaction Reference
2014-04-22 R-HSA-5368580 CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression BibTex
2014-04-22 R-HSA-5368582 CXXC4 binds DVL to prevent AXIN binding BibTex
2014-04-22 R-NUL-5368583 Cxxc4 binds DVL to prevent AXIN binding BibTex
2014-04-22 R-HSA-5368588 DVL binds CCDC88C BibTex
2014-04-22 R-NUL-5368587 DVL binds Ccdc88c BibTex
2014-04-22 R-HSA-5368596 WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 BibTex
2014-04-22 R-HSA-5368586 DKK promotes clathrin-dependent internalization of LRP6 BibTex
2013-11-13 R-HSA-5140747 FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner BibTex
2013-11-13 R-HSA-5140741 WNT5A binds FZD and ROR receptors BibTex
2013-11-13 R-HSA-5138459 WNT5A:FZD4 is endocytosed BibTex
2013-11-13 R-HSA-5138433 p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis BibTex
2013-11-13 R-HSA-5138432 DVL2 is phosphorylated by PKC BibTex
2013-11-13 R-HSA-5138441 WNT5A-FZD4 recruits DVL2 BibTex
2013-11-13 R-HSA-5099899 WNT5A binds FZD4 BibTex
Reviewed Pathways (14/14)
Date Identifier Pathway Reference
2014-01-22 R-HSA-201681 TCF dependent signaling in response to WNT BibTex
2014-01-22 R-HSA-3769402 Deactivation of the beta-catenin transactivating complex BibTex
2014-01-22 R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane BibTex
2014-01-22 R-HSA-4641263 Regulation of FZD by ubiquitination BibTex
2014-01-22 R-HSA-4641258 Degradation of DVL BibTex
2014-01-22 R-HSA-4641257 Degradation of AXIN BibTex
2014-01-22 R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists BibTex
2014-01-22 R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex BibTex
2014-01-22 R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters BibTex
2014-01-22 R-HSA-201688 WNT mediated activation of DVL BibTex
2013-11-13 R-HSA-3858494 Beta-catenin independent WNT signaling BibTex
2013-11-13 R-HSA-4086398 Ca2+ pathway BibTex
2013-11-13 R-HSA-4086400 PCP/CE pathway BibTex
2013-11-13 R-HSA-4608870 Asymmetric localization of PCP proteins BibTex
Reviewed Reactions (15/119)
Date Identifier Reaction Reference
2014-01-22 R-HSA-4411357 TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene BibTex
2014-01-22 R-HSA-4411367 TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene BibTex
2014-01-22 R-HSA-3361751 beta-catenin is replaced by repression complexes at the promoter BibTex
2014-01-22 R-HSA-3364042 APC promotes disassembly of beta-catenin transactivation complex BibTex
2014-01-22 R-HSA-3364014 Recruitment of SET1 methyltransferase complex BibTex
2014-01-22 R-HSA-201712 Beta-catenin:TCF associates with BCL9 and PYGO BibTex
2014-01-22 R-HSA-3299569 Beta-catenin displaces TLE:HDAC1 from TCF/LEF BibTex
2014-01-22 R-HSA-201669 Beta-catenin translocates to the nucleus BibTex
2014-01-22 R-HSA-201685 Beta-catenin is released from the destruction complex BibTex
2014-01-22 R-HSA-3601585 PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex BibTex
2014-01-22 R-HSA-3769393 YWHAZ binds p-CBY:CTNNB1 BibTex
2014-01-22 R-HSA-3769394 AKT phosphorylates CBY1 BibTex
2014-01-22 R-HSA-3769383 CBY1 binds beta-catenin BibTex
2014-01-22 R-HSA-3769392 YWHAZ and XPO1 mediate the nuclear export of beta-catenin BibTex
2014-01-22 R-HSA-3769391 XPO1 binds the beta-catenin:CBY complex BibTex