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Akira Kikuchi

 ORCID
Reviewed Reactions (119)
Date Identifier Reaction Reference
2014-01-22 R-HSA-4411357 TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene BibTex
2014-01-22 R-HSA-4411367 TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene BibTex
2014-01-22 R-HSA-3361751 beta-catenin is replaced by repression complexes at the promoter BibTex
2014-01-22 R-HSA-3364042 APC promotes disassembly of beta-catenin transactivation complex BibTex
2014-01-22 R-HSA-3364014 Recruitment of SET1 methyltransferase complex BibTex
2014-01-22 R-HSA-201712 Beta-catenin:TCF associates with BCL9 and PYGO BibTex
2014-01-22 R-HSA-3299569 Beta-catenin displaces TLE:HDAC1 from TCF/LEF BibTex
2014-01-22 R-HSA-201669 Beta-catenin translocates to the nucleus BibTex
2014-01-22 R-HSA-201685 Beta-catenin is released from the destruction complex BibTex
2014-01-22 R-HSA-3601585 PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex BibTex
2014-01-22 R-HSA-201691 Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI BibTex
2014-01-22 R-NUL-1458902 frog CK1gamma phosphorylates LRP5/6 BibTex
2014-01-22 R-HSA-201677 Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta BibTex
2014-01-22 R-HSA-1504186 DVL recruits GSK3beta:AXIN1 to the receptor complex BibTex
2014-01-22 R-HSA-1504188 FZD recruits DVL to the receptor complex BibTex
2014-01-22 R-DME-1504196 dDsh binds dFz2 BibTex
2014-01-22 R-NUL-1504194 mDvl1 binds FZD7 BibTex
2014-01-22 R-HSA-1458875 WNT binds to FZD and LRP5/6 BibTex
2014-01-22 R-HSA-3769393 YWHAZ binds p-CBY:CTNNB1 BibTex
2014-01-22 R-HSA-3769394 AKT phosphorylates CBY1 BibTex
2014-01-22 R-HSA-3769383 CBY1 binds beta-catenin BibTex
2014-01-22 R-HSA-3769392 YWHAZ and XPO1 mediate the nuclear export of beta-catenin BibTex
2014-01-22 R-HSA-3769391 XPO1 binds the beta-catenin:CBY complex BibTex
2014-01-22 R-HSA-3322431 XIAP binds TLE BibTex
2014-01-22 R-HSA-3322429 XIAP monoubiquinates TLE BibTex
2014-01-22 R-HSA-3322434 XIAP dissociates from ub-TLE BibTex
2014-01-22 R-HSA-3772430 CTNNBIP1 binds beta-catenin BibTex
2014-01-22 R-HSA-4641206 RSPOs bind LGRs BibTex
2014-01-22 R-HSA-4641236 USP8 deubiquitinates FZD to potentiate WNT signaling BibTex
2014-01-22 R-HSA-4641253 ZNRF3 ubiquitinates FZD to promote its downregulation BibTex
2014-01-22 R-HSA-4641249 ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex BibTex
2014-01-22 R-HSA-4641205 RSPO:LGR binds ZNRF3 BibTex
2014-01-22 R-HSA-4641246 ZNRF3 autoubiquitinates to promote its internalization BibTex
2014-01-22 R-HSA-4641159 DVL1 is ubiquitinated by HECW1 BibTex
2014-01-22 R-HSA-4641155 DVL1 is bound by the HECT ubiquitin ligase HECW1 BibTex
2014-01-22 R-HSA-1504213 DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex BibTex
2014-01-22 R-HSA-1504193 Ubiquitinated DVL is degraded by the proteasome BibTex
2014-01-22 R-HSA-1504190 DVL is ubiquitinated by CUL3:KLHL12:RBX1 BibTex
2014-01-22 R-HSA-4641260 Ubiquitinated DVL1 is degraded by the proteasome BibTex
2014-01-22 R-HSA-4641147 DACT1 binds DVL2 BibTex
2014-01-22 R-HSA-4641134 SMURF2 binds AXIN BibTex
2014-01-22 R-HSA-3640862 Tankyrase binds AXIN BibTex
2014-01-22 R-HSA-3640861 RNF146 ubiquitinates ADP-ribosylated AXIN BibTex
2014-01-22 R-HSA-3640844 RNF146 binds RibC-AXIN:TNKS complex BibTex
2014-01-22 R-HSA-3640858 Tankyrase ADP-ribosylates AXIN BibTex
2014-01-22 R-HSA-3640874 Ub-RibC-AXIN is degraded by the proteasome BibTex
2014-01-22 R-HSA-4641256 Ubiquitinated AXIN is degraded by the proteasome BibTex
2014-01-22 R-HSA-4641129 AXIN is ubiquitinated by SMURF2 BibTex
2014-01-22 R-HSA-3769401 DKK and KRM bind LRP5/6 BibTex
2014-01-22 R-HSA-3772441 sFRP binds WNT3A and inhibits WNT:FZD binding BibTex
2014-01-22 R-NUL-3772439 sFrp binds Wnt3a and inhibits WNT-FZD binding BibTex
2014-01-22 R-HSA-3769370 WIF1 binds WNTs BibTex
2014-01-22 R-MMU-3769366 Wif1 binds Wnts BibTex
2014-01-22 R-HSA-3769397 SOST binds LRP5/6 BibTex
2014-01-22 R-HSA-3322422 Beta-catenin recruits SMARCA4 BibTex
2014-01-22 R-HSA-3451153 Beta-catenin recruits TRRAP/KAT5 HAT components BibTex
2014-01-22 R-HSA-4411351 TCF/LEF:CTNNB1 bind the AXIN2 gene BibTex
2014-01-22 R-HSA-4411372 TCF/LEF:CTNNB1 promote transcription of AXIN2 BibTex
2014-01-22 R-HSA-3322427 Beta-catenin recruits CBP/p300 BibTex
2014-01-22 R-HSA-3364026 SET1 complex trimethylates H3K4 at the MYC gene BibTex
2014-01-22 R-HSA-3322424 Beta-catenin recruits CDC73 and LEO1 BibTex
2014-01-22 R-HSA-3451147 KAT5 HAT complex acetylates TCF4 gene at histone H4 BibTex
2014-01-22 R-HSA-201717 CSNK2-mediated phosphorylation of DVL BibTex
2014-01-22 R-HSA-3772435 WNT signaling stimulates CSNK1-dependent phosphorylation of DVL BibTex
2014-01-22 R-HSA-3772434 Phosphorylated DVL recruits PIP5K1B to the plasma membrane BibTex
2014-01-22 R-HSA-3772436 DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 BibTex
2014-01-22 R-HSA-3640872 USP34 deubiquitinates AXIN1,AXIN2 BibTex
2013-11-13 R-HSA-3965447 G-protein subunits dissociate from WNT:FZD complex BibTex
2013-11-13 R-HSA-3965444 WNT:FZD complex promotes G-protein nucleotide exchange BibTex
2013-11-13 R-HSA-3965441 FZD recruits trimeric G-proteins BibTex
2013-11-13 R-NUL-4551534 RFzd binds trimeric G-proteins BibTex
2013-11-13 R-HSA-3965446 WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling BibTex
2013-11-13 R-NUL-3965440 Wnt5a/11b bind Ca2+ Fzd receptors BibTex
2013-11-13 R-HSA-3858489 ppDVL binds DAAM1 BibTex
2013-11-13 R-HSA-3858480 WNT-dependent phosphorylation of DVL BibTex
2013-11-13 R-NUL-3858478 Rat Dvl is phosophorylated upon Wnt binding BibTex
2013-11-13 R-HSA-3858482 DVL is recruited to the receptor BibTex
2013-11-13 R-HSA-3858491 WNTs bind the FZD receptor to initiate PCP pathway BibTex
2013-11-13 R-XLA-4568832 Wnt11 binds Fzd7 to regulate convergent extension in Xenopus BibTex
2013-11-13 R-HSA-3858495 DAAM1 recruits GTP-bound RHOA BibTex
2013-11-13 R-HSA-4332358 Dissociation of CaM and CAMK2 autophosphorylation BibTex
2013-11-13 R-HSA-4332363 Autophosphorylation and activation of CAMK2 BibTex
2013-11-13 R-HSA-4332359 Active calmodulin binds CAMK2 BibTex
2013-11-13 R-HSA-4086392 PDE6 hydrolyses cGMP to GMP BibTex
2013-11-13 R-HSA-4086393 G alpha t2 binds and activates PDE6 BibTex
2013-11-13 R-MMU-4086394 Gnat2 binds and activates Pde6 BibTex
2013-11-13 R-HSA-4332356 CAMK2 binds MAP3K7 BibTex
2013-11-13 R-HSA-4411402 Activation of NLK BibTex
2013-11-13 R-HSA-4332388 Activation of MAP3K7 in response to WNT BibTex
2013-11-13 R-HSA-4518585 NLK mRNA translation controlled by miR-92b BibTex
2013-11-13 R-HSA-4332390 Translocation and activation of PKC alpha in response to WNT signaling BibTex
2013-11-13 R-XLA-4332392 translocation of Xenopus prkca to plasma membrane BibTex
2013-11-13 R-HSA-4420052 Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT BibTex
2013-11-13 R-HSA-4551453 PRKG is activated by binding to high levels of cGMP in the absence of WNT signaling BibTex
2013-11-13 R-MMU-4551446 Prkg is activated upon cGMP binding BibTex
2013-11-13 R-HSA-4551451 Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling BibTex
2013-11-13 R-HSA-8944362 TCF/LEF:CTNNB1 bind canonical WNT target promoters BibTex
2013-11-13 R-HSA-4411365 Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF BibTex
2013-11-13 R-HSA-4518575 miR-92b binds 3'UTR of NLK mRNA BibTex
2013-11-13 R-HSA-4551465 Translocation of NFATC1:CaN:CaM to nucleus BibTex
2013-11-13 R-HSA-4411373 NLK translocates to nucleus BibTex
2013-11-13 R-HSA-4411383 NLK phosphorylates TCF/LEF BibTex
2013-11-13 R-HSA-4608854 SMURF1/2 are recruited to the DVL2:PARD6A complex BibTex
2013-11-13 R-HSA-4608825 DVL2 is phosphorylated after WNT5A binding to FZD BibTex
2013-11-13 R-HSA-5099886 WNT5A binding to FZD promotes PRICKLE1 degradation BibTex
2013-11-13 R-HSA-4608855 PRICKLE1 is degraded by the proteasome BibTex
2013-11-13 R-HSA-4608852 SMURF1/2 ubiquitinates PRICKLE1 BibTex
2013-11-13 R-HSA-4608866 VANGL2 is required for asymmetric membrane localization of FZD3 BibTex
2013-11-13 R-MMU-4608842 Fz3 asymmetric membrane localization depends on direct interaction with Vangl2 BibTex
2013-11-13 R-MMU-4608838 Scrib is required for Vangl2 asymmetric membrane localization in mouse BibTex
2013-11-13 R-HSA-4608862 SCRIB is required for asymmetric membrane localization of VANGL2 BibTex
2013-11-13 R-HSA-4551555 RYK binds WNT5A and VANGL2 BibTex
2013-11-13 R-NUL-4551554 Wnt5a binds RYK and VANGL2 BibTex
2013-11-13 R-HSA-3858475 ppDVL recruits RAC BibTex
2013-11-13 R-HSA-3965450 DAAM1 recruits PFN1 BibTex
2013-11-13 R-HSA-4551571 WNT5A binds ROR2 and VANGL2 BibTex
2013-11-13 R-MMU-4551566 Wnt5a binds Ror2 and Vangl2 BibTex
2013-11-13 R-HSA-4551570 VANGL2 is phosphorylated in response to WNT5A BibTex
2013-11-13 R-MMU-4551572 Vangl2 is phosphorylated in response to Wnt5a BibTex
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