James A Borowiec

 ORCID
Affiliation
NYU School of Medicine, Department of Biochemistry
Authored Pathways (1/1)
Date Identifier Pathway Reference
2006-02-25 R-HSA-176187 Activation of ATR in response to replication stress BibTex
Authored Reactions (8/8)
Date Identifier Reaction Reference
2006-02-25 R-HSA-5684875 Binding of ATR:ATRIP to RPA at resected DNA DSBs BibTex
2006-02-25 R-HSA-176116 Recruitment and activation of Chk1 BibTex
2006-02-25 R-HSA-176264 Recruitment of the Rad9-Hus1-Rad1 complex to DNA BibTex
2006-02-25 R-HSA-176101 Recruitment of Rad17-RFC complex to DNA BibTex
2006-02-25 R-HSA-176175 Stalling of DNA replication fork and RPA binding BibTex
2006-02-25 R-HSA-176298 Activation of claspin BibTex
2006-02-25 R-HSA-176318 Loading of claspin onto DNA during replication origin firing BibTex
2006-02-25 R-HSA-176250 Binding of ATR-ATRIP to the RPA-ssDNA complex BibTex
Reviewed Pathways (15/65)
Date Identifier Pathway Reference
2015-06-12 R-HSA-5693548 Sensing of DNA Double Strand Breaks BibTex
2015-06-12 R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks BibTex
2015-06-12 R-HSA-5685939 HDR through MMEJ (alt-NHEJ) BibTex
2015-06-12 R-HSA-5693606 DNA Double Strand Break Response BibTex
2019-08-16 R-HSA-5693571 Nonhomologous End-Joining (NHEJ) BibTex
2015-06-12 R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) BibTex
2015-06-12 R-HSA-5685942 HDR through Homologous Recombination (HRR) BibTex
2015-06-12 R-HSA-5693537 Resolution of D-Loop Structures BibTex
2015-06-12 R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BibTex
2015-06-12 R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates BibTex
2015-06-12 R-HSA-5693579 Homologous DNA Pairing and Strand Exchange BibTex
2015-06-12 R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange BibTex
2015-06-12 R-HSA-5693607 Processing of DNA double-strand break ends BibTex
2015-06-12 R-HSA-5685938 HDR through Single Strand Annealing (SSA) BibTex
2015-06-12 R-HSA-5693532 DNA Double-Strand Break Repair BibTex
Reviewed Reactions (15/294)
Date Identifier Reaction Reference
2015-06-12 R-HSA-5683735 CHEK2 is recruited to DNA DSBs BibTex
2015-06-12 R-HSA-5693551 Phosphorylation of BRCA1-A complex at multiple sites by ATM BibTex
2015-06-12 R-HSA-5683385 Formation of BRCA1-A complex at DNA DSBs BibTex
2015-06-12 R-HSA-5659781 BRCA1 forms a heterodimer with BARD1 BibTex
2015-06-12 R-HSA-5683384 UIMC1 and FAM175A bind DNA DSBs BibTex
2015-06-12 R-HSA-5683425 ATM phosphorylates TP53BP1 at DNA DSBs BibTex
2015-06-12 R-HSA-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs BibTex
2015-06-12 R-HSA-5683077 RNF8 and RNF168 ubiquitinate KDM4A,B BibTex
2015-06-12 R-HSA-5682858 RNF8 and RNF168 ubiquitinate H2AFX BibTex
2015-06-12 R-HSA-5682863 RNF168 binds DNA DSBs BibTex
2015-06-12 R-HSA-5682629 HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 BibTex
2015-06-12 R-HSA-5682607 PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs BibTex
2015-06-12 R-HSA-5682598 ATM phosphorylates HERC2 BibTex
2015-06-12 R-HSA-5682586 HERC2 and PIAS4 are recruited to DNA DSBs BibTex
2015-06-12 R-HSA-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs BibTex