Carl-Henrik Heldin

 ORCID
Affiliation
Ludwig Institute for Cancer Research, Uppsala Branch
Authored Pathways (1/1)
Date Identifier Pathway Reference
2006-02-02 R-HSA-170834 Signaling by TGF-beta Receptor Complex BibTex
Authored Reactions (15/22)
Date Identifier Reaction Reference
2006-02-02 R-HSA-173488 The SMAD2/3:SMAD4 complex transfers to the nucleus BibTex
2006-02-02 R-HSA-170847 Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 BibTex
2006-02-02 R-HSA-170850 Phosphorylated SMAD2/3 dissociates from TGFBR BibTex
2006-02-02 R-HSA-170868 Activated type I receptor phosphorylates SMAD2/3 directly BibTex
2006-02-02 R-HSA-170835 An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 BibTex
2006-02-02 R-HSA-170843 TGFBR2 phosphorylates TGFBR1 BibTex
2006-02-02 R-HSA-170846 TGFBR2 recruits TGFBR1 BibTex
2006-02-02 R-HSA-170861 Dimeric TGF-beta-1 binds to the receptor BibTex
2006-02-02 R-HSA-177107 Secretion and activation of the latent large complex of TGF-beta-1 BibTex
2006-02-02 R-HSA-170844 Latent TGF-beta-1 is cleaved by furin BibTex
2006-02-02 R-HSA-173481 SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling BibTex
2006-02-02 R-HSA-173545 Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling BibTex
2006-02-02 R-HSA-178178 PP1 dephosphorylates TGFBR1 BibTex
2006-02-02 R-NUL-2167872 PP1CC dephosphorylates TGFBR1 BibTex
2006-02-02 R-HSA-178189 SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR BibTex
Reviewed Pathways (10/10)
Date Identifier Pathway Reference
2008-11-23 R-HSA-186763 Downstream signal transduction BibTex
2008-11-23 R-HSA-186797 Signaling by PDGF BibTex
2008-02-28 R-HSA-177929 Signaling by EGFR BibTex
2008-02-12 R-HSA-212718 EGFR interacts with phospholipase C-gamma BibTex
2008-02-12 R-HSA-180336 SHC1 events in EGFR signaling BibTex
2008-02-12 R-HSA-179812 GRB2 events in EGFR signaling BibTex
2008-02-12 R-HSA-180292 GAB1 signalosome BibTex
2008-02-12 R-HSA-182971 EGFR downregulation BibTex
2007-11-12 R-HSA-201451 Signaling by BMP BibTex
2006-04-18 R-HSA-170834 Signaling by TGF-beta Receptor Complex BibTex
Reviewed Reactions (15/96)
Date Identifier Reaction Reference
2008-11-23 R-HSA-186780 PI3-kinase binds to the active receptor BibTex
2008-11-23 R-HSA-186786 Autophosphorylation of PDGF beta receptors BibTex
2008-11-23 R-HSA-186773 PDGF dimer binds two receptors simultaneously BibTex
2008-11-23 R-HSA-8865275 PDGF-BB clevage by Furin BibTex
2008-11-23 R-HSA-382053 Translocation of PDGF from ER to Golgi BibTex
2008-11-23 R-HSA-186785 PDGF-AA clevage by Furin BibTex
2008-11-23 R-HSA-8865276 PDGF-AB clevage by Furin BibTex
2008-11-23 R-HSA-389086 Autophosphorylation of PDGF alpha/beta receptors BibTex
2008-11-23 R-HSA-389083 Autophosphorylation of PDGF alpha receptors BibTex
2008-11-23 R-HSA-186826 Grb2/Sos1 complex binds to the active receptor BibTex
2008-11-23 R-HSA-382058 Nck binds to the active PDGF receptor BibTex
2008-11-23 R-HSA-186834 Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos) BibTex
2008-11-23 R-HSA-186800 PI3K catalyses the phosphorylation of PIP2 to PIP3 BibTex
2008-11-23 R-HSA-1524186 Phosphorylation of PLCgamma by PDGFR BibTex
2008-11-23 R-HSA-186765 PLC-gamma binds to the active receptor BibTex