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Sara Zaccara

 ORCID
Reviewed Reactions (247)
Date Identifier Reaction Reference
2015-05-14 R-HSA-380979 RHEB in mTORC1:RHEB:GTP hydrolyses GTP BibTex
2015-05-14 R-HSA-380927 p-AMPK phosphorylates TSC1:TSC2 BibTex
2014-12-30 R-HSA-165179 Formation of TSC1:TSC2 complex BibTex
2016-02-04 R-HSA-6799332 ATR phosphorylates TP53 BibTex
2016-02-04 R-HSA-6804762 TP53 forms homotetramers BibTex
2016-02-04 R-HSA-6804188 PRDM1 represses TP53 expression BibTex
2016-02-04 R-HSA-6804194 PRDM1 binds the TP53 gene BibTex
2016-02-04 R-HSA-6804193 TP53 stimulates PRDM1 expression BibTex
2016-02-04 R-HSA-6804191 TP53 binds the PRDM1 gene BibTex
2016-02-04 R-HSA-6805285 PLK3 phosphorylates TP53 BibTex
2008-05-07 R-HSA-5693609 ATM phosphorylates TP53 at S15 BibTex
2016-02-04 R-HSA-6805470 AMPK phosphorylates TP53 BibTex
2016-02-04 R-HSA-6805479 TP53RK phosphorylates TP53 BibTex
2016-02-04 R-HSA-69685 CHEK2 phosphorylates TP53 BibTex
2016-02-04 R-HSA-6799246 CHEK1 phosphorylates TP53 BibTex
2016-02-04 R-HSA-6798268 TP53 and E2F4 inhibit CDC25C expression BibTex
2016-02-04 R-HSA-6798282 TP53 and E2F4 bind the CDC25C gene BibTex
2013-09-03 R-HSA-6804879 MDM2 ubiquitinates TP53 BibTex
2016-02-04 R-HSA-5633460 MDM2 binds TP53 BibTex
2016-02-04 R-HSA-6804741 MDM2 forms homo- or heterodimers BibTex
2016-02-04 R-HSA-6793666 MDM2 translocates to the nucleus BibTex
2016-02-04 R-HSA-6795460 SGK1 phosphorylates MDM2 BibTex
2016-02-04 R-HSA-6795473 PDPK1 phosphorylates SGK1 BibTex
2016-02-04 R-HSA-6795290 TORC2 complex phosphorylates SGK1 BibTex
2007-11-08 R-HSA-198599 AKT phosphorylates MDM2 BibTex
2016-02-04 R-HSA-6795667 MDM2 translocates to the cytosol BibTex
2016-02-04 R-HSA-3700992 TP53 stimulates MDM2 transcription BibTex
2016-02-04 R-HSA-3700997 TP53 binds the MDM2 gene BibTex
2016-02-04 R-HSA-70377 alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ BibTex
2003-06-25 R-HSA-70475 D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate BibTex
2014-12-30 R-HSA-5628905 TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate BibTex
2014-12-30 R-HSA-5628901 TP53 stimulates TIGAR expression BibTex
2014-12-30 R-HSA-5628899 TP53 binds the TIGAR gene BibTex
2014-12-30 R-HSA-8944104 PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN BibTex
2014-12-30 R-HSA-5632939 TP53 binds the PTEN promoter BibTex
2014-12-30 R-HSA-5632993 PTEN gene transcription is stimulated by TP53 BibTex
2016-02-04 R-HSA-6803719 TP53 binds ZNF385A BibTex
2016-02-04 R-HSA-6803437 TP53 stimulates ZNF385A transcription BibTex
2016-02-04 R-HSA-6803425 TP53 binds ZNF385A gene BibTex
2016-02-04 R-HSA-6803411 PCBP4 modulates CDKN1A translation BibTex
2016-02-04 R-HSA-6803403 PCBP4 binds the CDKN1A mRNA BibTex
2006-10-06 R-HSA-6803388 TP53 stimulates CDKN1A (p21) transcription BibTex
2013-09-03 R-HSA-6803801 TP53 in complex with ZNF385A binds the CDKN1A promoter BibTex
2016-02-04 R-HSA-6803400 TP53 stimulates PCBP4 expression BibTex
2016-02-04 R-HSA-6803391 TP53 binds the PCBP4 gene BibTex
2016-02-04 R-HSA-349455 Phosphorylation of MDM4 by ATM BibTex
2016-02-04 R-HSA-6804724 MDM2 ubiquitinates phosphorylated MDM4 BibTex
2016-02-04 R-HSA-349426 Phosphorylation of MDM4 by CHEK2 BibTex
2016-02-04 R-HSA-6793685 Ubiquitinated TP53 translocates to the cytosol BibTex
2016-02-04 R-HSA-6804955 ATM phosphorylates MDM2 BibTex
2016-02-04 R-HSA-69562 Inactivation of Cyclin E:Cdk2 complexes by p27/p21 BibTex
2006-10-06 R-HSA-187934 Inactivation of Cyclin A:Cdk2 complexes by p27/p21 BibTex
2016-02-04 R-HSA-6800794 PIDD1 associates with CRADD BibTex
2016-02-04 R-HSA-6800793 PIDD1 translocates to the cytosol BibTex
2016-02-04 R-HSA-6800490 ATM phosphorylates PIDD1 BibTex
2016-02-04 R-HSA-6800396 TP53 stimulates PIDD1 expression BibTex
2016-02-04 R-HSA-6800279 TP53 binds the PIDD1 gene BibTex
2016-02-04 R-HSA-6800797 The PIDDosome activates CASP2 BibTex
2016-02-04 R-HSA-6800798 The PIDDosome binds CASP2 BibTex
2016-02-04 R-HSA-6801415 TP53 stimulates NLRC4 expression BibTex
2016-02-04 R-HSA-6801355 TP53 binds the NLRC4 gene BibTex
2016-02-04 R-HSA-6798082 TP53 family members bind the CASP1 gene BibTex
2016-02-04 R-HSA-6798081 TP53 family members stimulate CASP1 expression BibTex
2016-02-04 R-HSA-6798126 TP53 stimulates CASP6 expression BibTex
2016-02-04 R-HSA-6798129 TP53 binds the CASP6 gene BibTex
2016-02-04 R-HSA-6791349 TP53 binds the APAF1 gene promoter BibTex
2016-02-04 R-HSA-6791348 TP53 stimulates APAF1 gene expression BibTex
2016-02-04 R-HSA-6798139 TP53 stimulates CASP10 expression BibTex
2016-02-04 R-HSA-6798138 TP53 binds the CASP10 gene BibTex
2016-02-04 R-HSA-6801109 CHM binds RGGT BibTex
2016-02-04 R-HSA-6801101 RABGGTA binds RABGGTB BibTex
2016-02-04 R-HSA-6801089 TP53 stimulates RABGGTA expression BibTex
2016-02-04 R-HSA-6801087 TP53 binds the RABGGTA gene BibTex
2016-02-04 R-HSA-6799466 TP53I3 dimerizes BibTex
2016-02-04 R-HSA-6799441 TP53 stimulates expression of the TP53I3 (PIG3) gene BibTex
2016-02-04 R-HSA-6799462 TP53 family members bind the TP53I3 (PIG3) gene promoter BibTex
2016-02-04 R-HSA-6799777 TP53 family members bind PPP1R13B or TP53BP2 BibTex
2016-02-04 R-HSA-6799722 TP53I3 oxidoreductase generates unstable semiquinones BibTex
2016-02-04 R-HSA-6797766 TP53 binds the BIRC5 gene BibTex
2016-02-04 R-HSA-6800836 TP53 or TP63 binds the PERP gene BibTex
2016-02-04 R-HSA-6797763 TP53 inhibits BIRC5 expression BibTex
2016-02-04 R-HSA-6799733 Semiquinone reacts with oxygen BibTex
2016-02-04 R-HSA-5633314 TP53 stimulates NDRG1 gene expression BibTex
2016-02-04 R-HSA-5633295 TP53 binds the NDRG1 gene promoter BibTex
2016-02-04 R-HSA-6800816 TP53 or TP63 stimulates PERP gene expression BibTex
2016-02-04 R-HSA-6791327 TP53 binds the BCL2L14 gene BibTex
2016-02-04 R-HSA-6800253 TP53 binds the BCL6 gene BibTex
2016-02-04 R-HSA-6791323 TP53 stimulates BCL2L14 gene expression BibTex
2016-02-04 R-HSA-6800250 TP53 stimulates BCL6 expression BibTex
2016-02-04 R-HSA-6800035 IGFBP3 binds TMEM219 BibTex
2016-02-04 R-HSA-6800044 TP53 stimulates IGFBP3 expression BibTex
2016-02-04 R-HSA-6800042 TP53 binds the IGFBP3 gene BibTex
2016-02-04 R-HSA-6799815 TP53 family members bind the FAS gene BibTex
2016-02-04 R-HSA-5633414 TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes BibTex
2016-02-04 R-HSA-5633441 TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes BibTex
2016-02-04 R-HSA-6800001 TP53 family members stimulate FAS gene expression BibTex
2016-02-04 R-HSA-6801250 TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane BibTex
2016-02-04 R-HSA-6801242 TRIAP1 binds PRELID1, PRELID3A BibTex
2016-02-04 R-HSA-6801213 TP53 stimulates TRIAP1 expression BibTex
2016-02-04 R-HSA-6801209 TP53 binds the TRIAP1 gene BibTex
2016-02-04 R-HSA-6799097 ATM phosphorylates ZNF420 BibTex
2016-02-04 R-HSA-6801195 STEAP3 binds BNIP3L BibTex
2016-02-04 R-HSA-6798004 TP53 stimulates BNIP3L expression BibTex
2016-02-04 R-HSA-6797993 TP53 and CREBBP bind BNIP3L gene BibTex
2016-02-04 R-HSA-6801184 TP53 stimulates STEAP3 expression BibTex
2016-02-04 R-HSA-6801166 TP53 binds the STEAP3 gene BibTex
2016-02-04 R-HSA-3700984 TP53 family members stimulate BAX transcription BibTex
2016-02-04 R-HSA-3700981 TP53 family members bind the BAX promoter BibTex
2016-02-04 R-HSA-4331331 TP53 binds the PMAIP1 (NOXA) promoter BibTex
2016-02-04 R-HSA-6798624 ZNF420 binds TP53AIP1 gene BibTex
2016-02-04 R-HSA-139913 TP53 stimulates BBC3 (PUMA) expression BibTex
2016-02-04 R-HSA-4331340 TP53 binds the BBC3 (PUMA) promoter BibTex
2016-02-04 R-HSA-6791285 TP53 binds the BID gene promoter BibTex
2016-02-04 R-HSA-6791291 TP53 stimulates BID gene expression BibTex
2016-02-04 R-HSA-6799418 TP53 binds the TP53INP1 gene BibTex
2016-02-04 R-HSA-6799416 TP53 stimulates expression of TP53INP1 BibTex
2016-02-04 R-HSA-6791302 TP53 binds the AIFM2 gene promoter BibTex
2016-02-04 R-HSA-6791306 TP53 stimulates AIFM2 gene expression BibTex
2016-02-04 R-HSA-6798615 TP53 binds the TP53AIP1 gene BibTex
2016-02-04 R-HSA-6798374 DYRK2 phosphorylates TP53 BibTex
2016-02-04 R-HSA-6798372 ATM phosphorylates DYRK2 BibTex
2016-02-04 R-HSA-6799409 HIPK2 phosphorylates TP53 BibTex
2016-02-04 R-HSA-3215251 TP53INP1 and HIPK2 bind TP53 BibTex
2016-02-04 R-HSA-140214 TP53 stimulates PMAIP1 (NOXA) expression BibTex
2016-02-04 R-HSA-6798611 TP53 stimulates and ZNF420 inhibits TP53AIP1 expression BibTex
2007-11-08 R-HSA-198609 AKT phosphorylates TSC2, inhibiting it BibTex
2013-09-03 R-HSA-3239014 MAPKAPK5 phosphorylates TP53 BibTex
2016-02-04 R-HSA-6805638 KAT6A acetylates TP53 BibTex
2016-02-04 R-HSA-6805620 KAT6A and PML bind TP53 BibTex
2016-02-04 R-HSA-6805640 AKT phosphorylates KAT6A BibTex
2016-02-04 R-HSA-5628871 BRD7 promotes EP300-mediated acetylation of TP53 BibTex
2016-02-04 R-HSA-3222093 BRD7 binds TP53 and EP300 BibTex
2016-02-04 R-HSA-6805650 MTA2-NuRD complex deacetylates TP53 BibTex
2016-02-04 R-HSA-6805399 TAF1 phosphorylates TP53 BibTex
2016-02-04 R-HSA-6805061 CK2 binds FACT BibTex
2016-02-04 R-HSA-6798373 MDM2 ubiquitinates DYRK2 BibTex
2016-02-04 R-HSA-6805059 CK2:FACT phosphorylates TP53 BibTex
2016-02-04 R-HSA-3222006 STK11 (LKB1) phosphorylates NUAK1 BibTex
2016-02-04 R-HSA-6805035 TP53 binds STK11 and NUAK1 BibTex
2016-02-04 R-HSA-6805276 CDK5 phosphorylates TP53 BibTex
2016-02-04 R-HSA-6805126 AURKB phosphorylates TP53 BibTex
2016-02-04 R-HSA-6805122 AURKB binds TP53 BibTex
2016-02-04 R-HSA-3222128 NOC2L binds TP53 BibTex
2016-02-04 R-HSA-6799431 TP53 binds HIPK1 BibTex
2016-02-04 R-HSA-6805109 CDK2 phosphorylates TP53 BibTex
2016-02-04 R-HSA-6805103 AURKA phosphorylates TP53 BibTex
2016-02-04 R-HSA-3222020 NUAK1 phosphorylates TP53 BibTex
2016-02-04 R-HSA-3215310 USP7 deubiquitinates TP53 and counteracts MDM2 BibTex
2016-02-04 R-HSA-6805022 USP2 binds the heterodimer of MDM2 and MDM4 BibTex
2016-02-04 R-HSA-6792871 CCNG1 recruits PP2A-PPP2R5C to MDM2 BibTex
2016-02-04 R-HSA-6793661 (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 BibTex
2016-02-04 R-HSA-6792491 TP53 stimulates CCNG1 gene expression BibTex
2016-02-04 R-HSA-6791409 TP53 binds the CCNG1 gene BibTex
2016-02-04 R-HSA-6804441 RNF34 or RFFL ubiquitinates phosphorylated TP53 BibTex
2016-02-04 R-HSA-5689972 USP2 deubiquitinates MDM2,MDM4 BibTex
2016-02-04 R-HSA-3222072 DAXX binds Ub-MDM2 and USP7 BibTex
2016-02-04 R-HSA-6804942 MDM2 homodimers auto-ubiquitinate BibTex
2016-02-04 R-HSA-6792863 PP2A-PP2R5C dephosphorylates MDM2 BibTex
2016-02-04 R-HSA-3215295 USP7 deubiquitinates MDM2 BibTex
2013-09-03 R-HSA-6804998 p14ARF forms a ternary complex with MDM2 and TP53 BibTex
2013-09-03 R-HSA-6804996 p14ARF sequesters MDM2 BibTex
2016-02-04 R-HSA-6798299 TP53 stimulates E2F7 expression BibTex
2016-02-04 R-HSA-6798304 TP53 binds the E2F7 gene BibTex
2016-02-04 R-HSA-6791363 TP53 stimulates ARID3A gene expression BibTex
2016-02-04 R-HSA-6791387 TP53 binds the ARID3A gene BibTex
2016-02-04 R-HSA-6798347 E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter BibTex
2016-02-04 R-HSA-6798353 E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression BibTex
2016-02-04 R-HSA-6801666 PLK2 phosphorylates CENPJ BibTex
2016-02-04 R-HSA-6801637 TP53 stimulates PLK2 expression BibTex
2016-02-04 R-HSA-6801641 TP53 binds the PLK2 gene BibTex
2016-02-04 R-HSA-6798044 BTG2 binds CCR4-NOT complex BibTex
2016-02-04 R-HSA-6798031 TP53 stimulates BTG2 expression BibTex
2016-02-04 R-HSA-6798020 TP53 binds the BTG2 gene BibTex
2016-02-04 R-HSA-6802973 PLK3 phosphorylates CDC25C BibTex
2016-02-04 R-HSA-6802170 TP53 stimulates PLK3 expression BibTex
2016-02-04 R-HSA-6802165 TP53 binds the PLK3 gene BibTex
2016-02-04 R-HSA-6801675 PLK2 phosphorylates NPM1 BibTex
2016-02-04 R-HSA-6803917 TP53 stimulates RGCC expression BibTex
2016-02-04 R-HSA-6803914 TP53 binds the RGCC gene BibTex
2016-02-04 R-HSA-6803946 TP53 stimulates PLAGL1 expression BibTex
2016-02-04 R-HSA-6803935 TP53 binds the PLAGL1 gene BibTex
2016-02-04 R-HSA-6791235 GADD45A binds AURKA BibTex
2016-02-04 R-HSA-3215144 TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription BibTex
2016-02-04 R-HSA-3215152 TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter BibTex
2016-02-04 R-HSA-6791109 GADD45A binds PCNA BibTex
2016-02-04 R-HSA-6803875 SFN dimer binds CDK1 and CCNB1 BibTex
2016-02-04 R-HSA-6803890 SFN dimerizes BibTex
2016-02-04 R-HSA-6803871 TP53 stimulates SFN expression BibTex
2016-02-04 R-HSA-6803858 TP53 binds the SFN gene BibTex
2016-02-04 R-HSA-6803892 SFN dimer binds BAX BibTex
2016-02-04 R-HSA-6805740 SETD8 methylates TP53 BibTex
2016-02-04 R-HSA-3222237 SMYD2 methylates TP53 BibTex
2016-02-04 R-HSA-6804253 MDM2 ubiquitinates JMY BibTex
2016-02-04 R-HSA-6804266 CHEK2 phosphorylates TTC5 BibTex
2016-02-04 R-HSA-6804276 ATM phosphorylates TTC5 BibTex
2016-02-04 R-HSA-6805730 SETD9 methylates TP53 BibTex
2016-02-04 R-HSA-6805755 EHMT1:EHMT2 dimethylates TP53 BibTex
2016-02-04 R-HSA-6804229 JMY, TTC5 and EP300 bind BibTex
2016-02-04 R-HSA-6804383 PRMT5 methylates TP53 BibTex
2016-02-04 R-HSA-6804379 PRMT5 binds TTC5 BibTex
2016-02-04 R-HSA-6804242 TP53 binds the complex of JMY, EP300 and TTC5 BibTex
2016-02-04 R-HSA-3222116 L3MBTL1 binds TP53 monomethylated on K382 BibTex
2016-02-04 R-HSA-3222259 PHF20 binds TP53 dimethylated on K370 and K382 BibTex
2016-02-04 R-HSA-6804425 TP53 binds POU4F2 BibTex
2016-02-04 R-HSA-6799761 TP53 binds PPP1R13L BibTex
2016-02-04 R-HSA-3221982 BANP binds TP53 BibTex
2016-02-04 R-HSA-6805792 p-S291-PHF20 translocates to cytosol BibTex
2016-02-04 R-HSA-6805785 AKT phosphorylates PHF20 BibTex
2016-02-04 R-HSA-6804402 TP53 binds POU4F1 BibTex
2016-02-04 R-HSA-70609 glutamine + H2O => glutamate + NH4+ [GLS] BibTex
2014-12-30 R-HSA-5632924 TP53 stimulates GLS2 transcription BibTex
2014-12-30 R-HSA-5632914 TP53 binds the GLS2 promoter BibTex
2016-02-04 R-HSA-71682 glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ BibTex
2014-12-30 R-HSA-5632732 p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 BibTex
2014-12-30 R-HSA-5631903 SESN1,2,3 bind overoxidized PRDX1 BibTex
2014-12-30 R-HSA-5631885 PRDX1 overoxidizes BibTex
2016-02-04 R-HSA-73646 thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ BibTex
2013-11-01 R-HSA-3341343 PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O BibTex
2014-12-30 R-HSA-5629189 TP53 stimulates expression of SESN1,2,3 genes BibTex
2014-12-30 R-HSA-5629187 TP53 binds regulatory elements of SESN1,2,3 genes BibTex
2016-02-04 R-HSA-163214 Electron transfer from reduced cytochrome c to molecular oxygen BibTex
2014-12-30 R-HSA-5631941 SESN1,2,3 bind AMPK BibTex
2014-12-30 R-HSA-5632386 TP63/TP53 stimulates transcription of DDIT4 gene BibTex
2014-12-30 R-HSA-5632393 TP63/TP53 bind the DDIT4 gene promoter BibTex
2014-12-30 R-HSA-5632759 TP53 binds the SCO2 gene BibTex
2014-12-30 R-HSA-5632887 TP53 binds the RRM2B gene BibTex
2014-12-30 R-HSA-5632892 TP53 stimulates transcription of RRM2B gene BibTex
2014-12-30 R-HSA-5632766 TP53 stimulates SCO2 gene transcription BibTex
2013-11-01 R-HSA-3341277 GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O BibTex
2014-12-30 R-HSA-5632738 DDIT4 binds 14-3-3 dimer BibTex
2016-02-04 R-HSA-6796647 TP53 stimulates CCNK expression BibTex
2016-02-04 R-HSA-6796649 TP53 binds the CCNK gene BibTex
2016-02-04 R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes BibTex
2016-02-04 R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes BibTex
2016-02-04 R-HSA-6797090 CCNK binds CDK12 BibTex
2016-02-04 R-HSA-6806405 TP53 stimulates PMS2 expression BibTex
2016-02-04 R-HSA-6806408 TP53 binds the PMS2 gene BibTex
2016-02-04 R-HSA-6806413 TP53 binds the MLH1 gene BibTex
2016-02-04 R-HSA-6806412 TP53 and AP-1 bind the MSH2 promoter BibTex
2016-02-04 R-HSA-6797100 CCNK binds CDK13 BibTex
2016-02-04 R-HSA-6806423 TP53 stimulates DDB2 expression BibTex
2016-02-04 R-HSA-6806417 TP53 binds the DDB2 gene BibTex
2016-02-04 R-HSA-6806419 TP53 binds the FANCC gene BibTex
2016-02-04 R-HSA-6797712 CDK12 stimulates expression of DNA repair genes BibTex
2016-02-04 R-HSA-6806394 TP53 and AP-1 stimulate MSH2 expression BibTex
2016-02-04 R-HSA-6806425 TP53 stimulates FANCC expression BibTex
2016-02-04 R-HSA-6806392 TP53 stimulates MLH1 expression BibTex