Search results for AACS

Showing 5 results out of 5

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Species

Types

Compartments

Reaction types

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Species

Types

Compartments

Reaction types

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-5694468
Species: Homo sapiens
Compartment: cytosol
Primary external reference: UniProt: AACS: Q86V21

Reaction (1 results from a total of 1)

Identifier: R-HSA-5694494
Species: Homo sapiens
Compartment: cytosol
Ketone bodies (KBs) are an energy source utilised by mammals, the terminal oxidation of which (termed ketogenesis) is most active during fasting states or starvation. This process normally occurs in the mitochondria of cells. Cytoplasmic de novo lipogenesis and cholesterol synthesis are nonoxidative metabolic fates of ketone bodies. Acetoacetyl-CoA synthetase (AACS) mediates the activation of acetoacetate (ACA) to the KB acetoacetyl-CoA (ACA-CoA) in the cytosol of cells of lipogenic tissues (Aquilo et al. 2010). AACS is proposed to provide an alternative supply of acetyl units from that of mitochondrial ketogenesis for de novo lipogenesis and cholesterol synthesis in the brain, based on rat experiments (Endemann et al. 1982, review Cotter et al. 2013). Human AACS mRNA is abundant in the kidney, heart and brain, but low in liver (Ohgami et al. 2003).

RNA Sequence (3 results from a total of 3)

Identifier: R-HSA-9708192
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: tRNA Val AAC: URS000061D582_9606
Identifier: R-HSA-9708330
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: URS000061D582_9606
Identifier: R-HSA-9708356
Species: Homo sapiens
Compartment: cytosol
Primary external reference: RNAcentral: URS000061D582_9606
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