Search results for ACSL3

Showing 7 results out of 7

×

Species

Types

Compartments

Reaction types

Search properties

Species

Types

Compartments

Reaction types

Search properties

Protein (2 results from a total of 2)

Identifier: R-HSA-9632656
Species: Homo sapiens
Compartment: mitochondrial outer membrane
Primary external reference: UniProt: ACSL3: O95573
Identifier: R-HSA-548787
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
Primary external reference: UniProt: ACSL3: O95573

Set (2 results from a total of 2)

Identifier: R-HSA-9632658
Species: Homo sapiens
Compartment: mitochondrial outer membrane
Identifier: R-HSA-2901793
Species: Homo sapiens
Compartment: endoplasmic reticulum membrane
This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis. Further candidates were identified by Ralf Stephan in a July 15, 2023 analysis.

Reaction (2 results from a total of 2)

Identifier: R-HSA-434382
Species: Homo sapiens
Compartment: mitochondrial outer membrane
ACSL3 and ACSL4 found on the mitochondria of pancreatic beta cells ligate coenzyme A (Co-A) to fatty acids such as palmitate (Ansari et al. 2017) prior to transport into mitochondria by the carnitine system and beta oxidation in the mitochondrial matrix yielding ATP.
Identifier: R-HSA-548843
Species: Homo sapiens
Compartment: cytosol, endoplasmic reticulum membrane
Acyl-CoA synthetase long-chain family member 4 (ACSL4) associated with the endoplasmic reticulum membrane catalyses the conjugation of arachidonate (AA) with CoA to form arachidonyl-CoA (AA-CoA) (Longo et al. 2003, Meloni et al. 2003). By similarity, ACSL3 can also preferentially conjugate CoA on to AA (Yao & Ye 2008). These enzymes are involved in the activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.

Pathway (1 results from a total of 1)

Identifier: R-HSA-434313
Species: Homo sapiens
Fatty acids augment the glucose triggered secretion of insulin through two mechanisms: activation of FFAR1 (GPR40) and intracellular metabolism of fatty acids. Fatty acids are transported into the cell by CD36 (FAT) (Noushmehr et al. 2005) and metabolized by ligation to coenzyme A (Ansari et al. 2017), transport into mitochondria, and beta oxidation which generates ATP. The ATP increases the intracellular ratio of ATP:ADP and thereby closes potassium channels (K(ATP) channels) at the plasma membrane (reviewed in Acosta-Montano and Garcia-Gonzalez 2018). The enzymes that metabolize fatty acids in beta cells also metabolize fatty acids in other tissues however their combinations and subcellular locations may differ.
Cite Us!