Search results for ACSM3

Showing 3 results out of 3

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Species

Types

Compartments

Search properties

Protein (1 results from a total of 1)

Identifier: R-HSA-8875035
Species: Homo sapiens
Compartment: mitochondrial matrix
Primary external reference: UniProt: ACSM3: Q53FZ2

Set (1 results from a total of 1)

Identifier: R-HSA-8875066
Species: Homo sapiens
Compartment: mitochondrial matrix

Reaction (1 results from a total of 1)

Identifier: R-HSA-8875013
Species: Homo sapiens
Compartment: mitochondrial matrix
Mitochondrial acyl-coenzyme A synthetase ACSM3 (aka protein SAH homolog) is expressed in the mitochondrial matrix and possesses medium-chain fatty acid:CoA ligase activity. Based on characterisation experiments in mice, ACSM3 preferentially ligates C2-C6 fatty acids, especially butyrate (BUT, a C4 fatty acid) (Fujino et al. 2001). The product, butyryl-CoA (BT-CoA) is used in beta oxidation. ACSM3 gene variants may be associated with obesity-related hypertension (Iwai et al. 1994, 2002, Telgmann et al. 2007, Tikhonoff et al. 2008). The mechanisms by which ACSM3 gene variants affect blood pressure remain to be elucidated.

Mitochondrial acyl-coenzyme A synthetase ACSM6 is proposed to be located in the mitochondrial matrix and possess the same medium-chain fatty acid:CoA ligase activity as ACSM3.
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